Recent Progress of Aggregation-Induced Emission Materials in Tumor Phototherapy

Cancer is a leading cause of death globally with its incidence rate on the rise. Phototherapy has emerged as a novel approach for precise cancer treatment, offering benefits such as non-invasiveness, no drug resistance, minimal side effects, and ease of operation. Since Prof. Ben Zhong Tang conceptually coined aggregation-induced emission (AIE) in 2001, AIE materials have been extensively applied as efficient photosensitive and photothermal agents. Thanks to their highly twisted molecular structure, AIE materials avoid the issue of π-π stacking in aggregated states, thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials. This advancement leads to a significant enhancement in quantum yield and photostability. Herein, the author comprehensively reviews the latest applications of AIE materials as photosensitizers, photothermal agents, and diagnostic agents in cancer phototherapy.

Key words： aggregation-induced emission; photodynamics therapy; photothermal therapy; multimodal combination therapy

Cite this article

Zixiang Meng , Xiumei Tian , Tianfu Zhang . Recent Progress of Aggregation-Induced Emission Materials in Tumor Phototherapy[J]. Chinese Journal of Organic Chemistry, 2024 , 44(8) : 2441 -2452 . DOI: 10.6023/cjoc202403058

References

[1]	Jiang, W. G.; Sanders, A. J.; Katoh, M.; Ungefroren, H.; Gieseler, F.; Prince, M.; Thompson, S. K.; Zollo, M.; Spano, D.; Dhawan, P.; Sliva, D.; Subbarayan, P. R.; Sarkar, M.; Honoki, K.; Fujii, H.; Georgakilas, A. G.; Amedei, A.; Niccolai, E.; Amin, A.; Ashraf, S. S.; Ye, L.; Helferich, W. G.; Yang, X.; Boosani, C. S.; Guha, G.; Ciriolo, M. R.; Aquilano, K.; Chen, S.; Azmi, A. S.; Keith, W. N,. Bilsland, A.; Bhakta, D.; Halicka, D.; Nowsheen, S.; Pantano, F.; Santini, D. Cancer Biol. 2015, 35, S244.
[2]	Sung, H.; Ferlay, J.; Siegel, R. L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. CA Cancer J. Cli.. 2021, 71, 209.
[3]	Siegel, R. L.; Miller, K. D.; Jemal, A. CA Cancer J. Cli.. 2023, 73, 17.
[4]	Jia, S.; Yuan, H.; Hu, R. Biomater. Sci. 2022, 10, 4443.
[5]	Jiang, Z.; Zhang, C.; Wang, X.; Yan, M.; Ling, Z.; Chen, Y.; Liu, Z. Angew. Chem., Int. Ed. 2021, 60, 22376.
[6]	Wan, Q.; Zhang, R.; Zhuang, Z.; Li, Y.; Huang, Y.; Wang, Z.; Zhang, W.; Hou, J.; Tang, B. Z. Adv. Funct. Mater. 2020, 30, 2002057.
[7]	Zhou, Z.; Li, B.; Shen, C.; Wu, D.; Fan, H.; Zhao, J.; Li, H.; Zeng, Z.; Luo, Z.; Ma, L.; Tan, C. Smal. 2020, 16, 2004173.
[8]	Yu, G.; Yang, Z.; Fu, X.; Yung, B.C.; Yang, J.; Mao, Z.; Shao, L.; Hua, B.; Liu, Y.; Zhang, F.; Fan, Q.; Wang, S.; Jacobson, O.; Jin, A.; Gao, C.; Tang, X.; Huang, F.; Chen, X. Nat. Commu.. 2018, 9, 766.
[9]	Zhou, Z.; Wang, X.; Zhang, H.; Huang, H.; Sun, L.; Ma, L.; Du, Y.; Pei, C.; Zhang, Q.; Li, H.; Ma, L.; Gu, L.; Liu, Z.; Cheng, L.; Tan, C. Smal. 2021, 17, 2007486.
[10]	Zhao, Y.; Chen, P.; Han, L.; Wang, E. Chin. J. Org. Chem. 2023, 43, 2454 (in Chinese).
[10]	(赵洋, 陈盼盼, 韩立志, 王恩举, 有机化学, 2023, 43, 2454.)
[11]	Zhao, Y.; Chen, P.; Li, G.; Niu, Z.; Wang, E. Chin. J. Org. Chem. 2023, 43, 2156 (in Chinese).
[11]	(赵洋, 陈盼盼, 李高楠, 钮智刚, 王恩举, 有机化学, 2023, 43, 2156.)
[12]	Lu, H.; Ma, L.; Ma, H. Chin. J. Org. Chem. 2023, 43, 4075 (in Chinese).
[12]	(鲁会名, 马拉毛草, 马恒昌, 有机化学, 2023, 43, 4075.)
[13]	Lyu, X.; Yu, J.; Zhang, L.; Zhao, Y.; Qiu, Z.; Chen, Y.; Zhao, Z.; Tang, B. Z. J. Mater. Chem. B 2023, 11, 5953.
[14]	Hu, F.; Liu, B. Biomol. Chem. 2016, 14, 9931.
[15]	Dharmaraja, A. T. J. Med. Che.. 2017, 60, 3221.
[16]	Feng, G.; Liu, B. Acc. Chem. Res. 2018, 51, 1404.
[17]	Wang, D.; Tang, B. Z. Acc. Chem. Re.. 2019, 52, 2559.
[18]	Zhao, Y.; Zhang, X.; Yang, Y.; Zhu, L.; Zhou, Y. Acta Chim. Sinic. 2024, 82, 265 (in Chinese).
[18]	(赵玉强, 张霞, 杨芸如, 朱立平, 周莹, 化学学报, 2024, 82, 265.)
[19]	Xu, W.; Zhang, Z.; Kang, M.; Guo, H.; Li, Y.; Wen, H.; Lee, M. M. S.; Wang, Z.; Kwok, R. T. K.; Lam, J. W. Y.; Li, K.; Xi, L.; Chen, S.; Wang, D.; Tang, B. Z. ACS Mater. Lett. 2020, 2, 1033.
[20]	Xu, S.; Wu, W.; Cai, X.; Zhang, C.; Yuan, Y.; Liang, J.; Feng, G.; Manghnani, P.; Liu, B. Chem. Commun. 2017, 53, 8727.
[21]	Wu, W.; Mao, D.; Hu, F.; Xu, S.; Chen, C.; Zhang, C.J.; Cheng, X.; Yuan, Y.; Ding, D.; Kong, D.; Liu, B. Adv. Mater. 2017, 29, 1700548.
[22]	Zheng, Z.; Liu, H.; Zhai, S.; Zhang, H.; Shan, G.; Kwok, R.; Ma, C.; Sung, H.; Williams, I.; Lam, J.; Wong, K.; Hu, X.; Tang, B. Z. Chem. Sc.. 2020, 11, 2494.
[23]	Zhang, T.; Yang, X.; Ou, X.; Lee, M. M. S.; Zhang, J.; Xu, C.; Yu, X.; Gong, P.; Lam, J. W. Y.; Zhang, P.; Tang, B. Z. Adv. Mate.. 2023, 35, 2303186.
[24]	Yang, Z.; Zhang, Z.; Sun, Y.; Lei, Z.; Wang, D.; Ma, H.; Tang, B. Z. Biomaterial. 2021, 275, 120934.
[25]	Zhuang, Z.; Dai, J.; Yu, M.; Li, J.; Shen, P.; Hu, R.; Lou, X.; Zhao, Z.; Tang, B. Z. Chem. Sci. 2020, 11, 3405.
[26]	Qin, A.; Lam, J. W. Y.; Tang, B. Z. Prog. Polym. Sc.. 2012, 37, 182.
[27]	Zhang, Y.; Ju, J.; Wang, D.; Yuan, H.; Hao, L.; Tan, Y. J. Mater. Chem. C 2021, 9, 11484.
[28]	Hu, R.; Qin, A.; Tang, B. Z. Prog. Polym. Sci. 2020, 100, 101176.
[29]	Hu, R.; Leung, N. L. C.; Tang, B. Z. Chem. Soc. Rev. 2014, 43, 4494.
[30]	Liu, S.; Zhang, H.; Li, Y.; Liu, J.; Du, L.; Chen, M.; Kwok, R. T. K.; Lam, J. W. Y.; Phillips, D. L.; Tang, B. Z. Angew. Chem., Int. Ed. 2018, 57, 15189.
[31]	Wu, W.; Feng, G.; Xu, S.; Liu, B. Macromolecule. 2016, 49, 5017.
[32]	Wu, W.; Mao, D.; Xu, S.; Kenry, R.; Hu, F.; Li, X.; Kong, D.; Liu, B. Che. 2018, 4, 1937.
[33]	Jung, H. S.; Verwilst, P.; Sharma, A.; Shin, J.; Sessler, J. L.; Kim, J. S. Chem. Soc. Rev. 2018, 47, 2280.
[34]	Xu, H.; Han, P.; Qin, A.; Tang, B. Z. Acta Chim. Sinic. 2023, 81, 1420 (in Chinese).
[34]	(徐赫, 韩鹏博, 秦安军, 唐本忠, 化学学报, 2023, 81, 1420.)
[35]	Yu, J.; Ju, Y.; Zhao, L.; Chu, X.; Yang, W.; Tian, Y.; Sheng, F.; Lin, J.; Liu, F.; Dong, Y.; Hou, Y. ACS Nan. 2016, 10, 159.
[36]	Xiao, Y.; An, F.; Chen, J.X.; Yu, J.; Tao, W. W.; Yu, Z.; Ting, R.; Lee, C. S.; Zhang, X. H. Smal. 2019, 15, 1903121.
[37]	Gao, S.; Wei, G.; Zhang, S.; Zheng, B.; Xu, J.; Chen, G.; Li, M.; Song, S.; Fu, W.; Xiao, Z.; Lu, W. Nat. Commu.. 2019, 10, 2206.
[38]	Zhang, M.; Wang, W.; Mohammadniaei, M.; Zheng, T.; Zhang, Q.; Ashley, J.; Liu, S.; Sun, Y.; Tang, B. Z. Adv. Mate.. 2021, 33, 2008802.
[39]	Ni, J.; Li, Y.; Yue, W.; Liu, B.; Li, K. Theranostic. 2020, 10, 1923.
[40]	Ni, J.; Zhang, P.; Jiang, T.; Chen, Y.; Su, H.; Wang, D.; Yu, Z.; Kwok, R.; Zhao, Z.; Lam, J.; Tang, B. Z. Adv. Mater. 2018, 30, 1805220.
[41]	Li, J.; Pu, K. Chem. Soc. Re.. 2019, 48, 38.
[42]	He, X.; Peng, C.; Qiang, S.; Xiong, L. H.; Zhao, Z.; Wang, Z.; Kwok, R. T. K.; Lam, J. W. Y.; Ma, N.; Tang, B. Z. Biomaterial. 2020, 238, 119834.
[43]	Liu, S.; Zhou, X.; Zhang, H.; Ou, H.; Lam, J. W. Y.; Liu, Y.; Shi, L.; Ding, D.; Tang, B. Z. J. Am. Chem. Soc. 2019, 141, 5359.
[44]	Lang, T.; Liu, Y.; Zheng, Z.; Ran, W.; Zhai, Y.; Yin, Q.; Zhang, P.; Li, Y. Adv. Mater. 2019, 31, 1806202.
[45]	Liu, J.; Song, L.; Liu, S.; Jiang, Q.; Liu, Q.; Li, N.; Wang, Z. G.; Ding, B. Nano Lett. 2018, 18, 3328.
[46]	Xie, Z.; Fan, T.; An, J.; Choi, W.; Duo, Y.; Ge, Y.; Zhang, B.; Nie, G.; Xie, N.; Zheng, T.; Chen, Y.; Zhang, H.; Kim, J. S. Chem. Soc. Rev. 2020, 49, 8065.
[47]	Sun, L.; Wang, D.; Chen, Y.; Wang, L.; Huang, P.; Li, Y.; Liu, Z.; Yao, H.; Shi, J. Biomaterial. 2017, 133, 219.
[48]	Qu, R.; Zhen, X.; Jiang, X. CCS Che.. 2022, 4, 401.
[49]	Xu, C.; Ye, R.; Shen, H.; Lam, J. W. Y.; Zhao, Z.; Tang, B. Z. Angew. Chem.; Int. Ed. 2022, 61, e202204604.
[50]	Song, N.; Zhang, Z.; Liu, P.; Dai, D.; Chen, C.; Li, Y.; Wang, L.; Han, T.; Yang, Y.; Wang, D.; Tang, B. Z. Adv. Funct. Mater. 2021, 31, 2009924.
[51]	Zhang, Z.; Xu, W.; Kang, M.; Wen, H.; Guo, H.; Zhang, P.; Xi, L.; Li, K.; Wang, L.; Wang, D.; Tang, B. Z. Adv. Mater. 2020, 32, 2003210.
[52]	Jiang, R.; Dai, J.; Dong, X.; Wang, Q.; Meng, Z.; Guo, J.; Yu, Y.; Wang, S.; Xia, F.; Zhao, Z.; Lou, X.; Tang, B. Z. Adv. Mate.. 2021, 33, 2101158.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References