Recent progress of aggregation-induced emission materials in tumor phototherapy

doi:10.6023/cjoc202403058

Abstract

Cancer is a leading cause of death globally, with its incidence rate on the rise. Phototherapy has emerged as a novel approach for precise cancer treatment, offering benefits such as non-invasiveness, tolerability, minimal side effects, and ease of operation. Since Prof. Ben Zhong Tang conceptually coined aggregation-induced emission (AIE) in 2001, AIE materials have been extensively applied as efficient photosensitive and photothermal agents. Thanks to their highly twisted molecular structure, AIE materials avoid the issue of π-π stacking in aggregated states, thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials. This advancement leads to a significant enhancement in quantum yield and photostability. Herein, the author comprehensively reviews the latest applications of AIE materials as photosensitizers, photothermal agents, and diagnostic agents in cancer phototherapy.

Key words: Aggregation-induced emission, Photodynamics therapy, Photothermal therapy, Multimodal combination therapy

Cite this article

Meng, Zixiang, Tian, Xiumei, Zhang, Tianfu. Recent progress of aggregation-induced emission materials in tumor phototherapy[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202403058.

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