REVIEWS

Aggregation-Induced Emission Materials for Tumor Phototheranostics

  • Weigeng Huang ,
  • Yiting Gao ,
  • Yan Sun ,
  • Dingyuan Yan ,
  • Dong Wang ,
  • BenZhong Tang
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  • a Center for Aggregation-Induced Emission (AIE) Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060
    b Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024
    c School of Science and Engineering, Shenzhen Institute of Molecular Aggregate Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172
† These authors contributed equally to this work.

Received date: 2024-03-31

  Revised date: 2024-06-19

  Online published: 2024-07-02

Supported by

National Natural Science Foundation of China(52122317); National Natural Science Foundation of China(22175120); National Natural Science Foundation of China(22307080); Developmental Fund for Science and Technology of Shenzhen Government(RCBS20221008093224016); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20220531101201003); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20190808153415062); Developmental Fund for Science and Technology of Shenzhen Government(20220809130438001); Developmental Fund for Science and Technology of Shenzhen Government(JSGG20220606141800001); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20200109110608167); Guangdong Basic and Applied Basic Research Fund(2023A1515010558)

Abstract

In recent years, aggregation-induced emission (AIE) materials have attracted much attention in the field of tumour treatment due to their excellent attributes of aggregation-enhanced theranostics. The AIE materials can dissipate the excited state energy through different energy relaxation pathways to generate reactive oxygen species or heat, which can be used for imaging-guided tumour phototherapy. The research progress of AIE materials for tumor phototheranostics is systematically summarized according to the different excitation modes, specifically photogenic excitation (including the use of white light, 660, 808, 980 or 1064 nm lasers), chemical excitation, ultrasonic excitation and X-ray excitation. In addition, the advantages and limitations of each excitation energy source are briefly discussed.

Cite this article

Weigeng Huang , Yiting Gao , Yan Sun , Dingyuan Yan , Dong Wang , BenZhong Tang . Aggregation-Induced Emission Materials for Tumor Phototheranostics[J]. Chinese Journal of Organic Chemistry, 2024 , 44(8) : 2413 -2424 . DOI: 10.6023/cjoc202403059

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