Aggregation-Induced Emission Materials for Tumor Phototheranostics

doi:10.6023/cjoc202403059

Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (8): 2413-2424.DOI: 10.6023/cjoc202403059 Previous Articles Next Articles

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聚集诱导发光材料用于肿瘤光学诊疗

黄伟庚^a, 高翼亭^a^,^b, 孙妍^a^,^b, 燕鼎元^a^,^*(), 王东^a^,^*(), 唐本忠^a^,^c^,^*()

a 深圳大学材料学院聚集诱导发光(AIE)研究中心广东深圳 518060
b 东北师范大学化学学院吉林省高校纳米生物传感与纳米生物分析重点实验室长春 130024
c 香港中文大学(深圳)理工学院深圳分子聚集体科学与工程研究院广东深圳 518172

收稿日期:2024-03-31 修回日期:2024-06-19 发布日期:2024-07-02
作者简介:
† 共同第一作者.
基金资助:
国家自然科学基金(52122317); 国家自然科学基金(22175120); 国家自然科学基金(22307080); 深圳市科技发展基金(RCBS20221008093224016); 深圳市科技发展基金(JCYJ20220531101201003); 深圳市科技发展基金(JCYJ20190808153415062); 深圳市科技发展基金(20220809130438001); 深圳市科技发展基金(JSGG20220606141800001); 深圳市科技发展基金(JCYJ20200109110608167); 及广东省基础与应用基础研究基金(2023A1515010558)

Aggregation-Induced Emission Materials for Tumor Phototheranostics

Weigeng Huang^a, Yiting Gao^a^,^b, Yan Sun^a^,^b, Dingyuan Yan^a(), Dong Wang^a(), BenZhong Tang^a^,^c()

a Center for Aggregation-Induced Emission (AIE) Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060
b Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024
c School of Science and Engineering, Shenzhen Institute of Molecular Aggregate Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172

Received:2024-03-31 Revised:2024-06-19 Published:2024-07-02
Contact: *E-mail: yandingyuan@szu.edu.cn; wangd@szu.edu.cn; tangbenz@cuhk.edu.cn
About author:
† These authors contributed equally to this work.
Supported by:
National Natural Science Foundation of China(52122317); National Natural Science Foundation of China(22175120); National Natural Science Foundation of China(22307080); Developmental Fund for Science and Technology of Shenzhen Government(RCBS20221008093224016); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20220531101201003); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20190808153415062); Developmental Fund for Science and Technology of Shenzhen Government(20220809130438001); Developmental Fund for Science and Technology of Shenzhen Government(JSGG20220606141800001); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20200109110608167); Guangdong Basic and Applied Basic Research Fund(2023A1515010558)

In recent years, aggregation-induced emission (AIE) materials have attracted much attention in the field of tumour treatment due to their excellent attributes of aggregation-enhanced theranostics. The AIE materials can dissipate the excited state energy through different energy relaxation pathways to generate reactive oxygen species or heat, which can be used for imaging-guided tumour phototherapy. The research progress of AIE materials for tumor phototheranostics is systematically summarized according to the different excitation modes, specifically photogenic excitation (including the use of white light, 660, 808, 980 or 1064 nm lasers), chemical excitation, ultrasonic excitation and X-ray excitation. In addition, the advantages and limitations of each excitation energy source are briefly discussed.

Key words: aggregation-induced emission, excitation source, tumor theranostics

Cite this article

Weigeng Huang, Yiting Gao, Yan Sun, Dingyuan Yan, Dong Wang, BenZhong Tang. Aggregation-Induced Emission Materials for Tumor Phototheranostics[J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2413-2424.

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Fig. & Tab. 9

Figure 1. (A) Phenomena of aggregation-induced emission (taking HPS as example) and aggregation-caused quenching (taking perylene as example), (B) schematic of the penetration depth of different bio-imaging windows, and (C) AIE materials under different excitation modalities for integrated tumor diagnosis and treatment

Figure 2. (A) Properties of MeTTPy, (B) FLI of normal and cancer cells stained with MeTTPy, (C) fluorescence images of MeTTPy in A431 loaded mice at different times after intratumor injection, (D) photo-oxidative dehydrogenation of TPA-DHPy-Py under light irradiation, (E) ROS generation efficiency of TPA-DHPy-Py in living cells; (F) FLI of nude mice injected intratumourally with TPA-DHPy-Py, (G) molecular design strategy and photophysical processes of TBFT2 and its application in FLI-guided tumor combined PDT/PTT, (H) cellular co-localization study of TBFT2 NPs; (I) ROS generation calculation of TBFT2 NPs in 4T1 cells, and (J) time-dependent FLI of 4T1 tumor-bearing mice after injection of TBFT2 NPs

Figure 3. (A) Schematic diagram of improved photothermal conversion by aggregation transition of BTPPA, (B) IR thermal images of 4T1 tumor-bearing mice after intravenous injection of PAE NPs and PEG NPs, (C) π-bridge engineering for the construction of multi-mode AIE materials, (D) fluorescence images of intracellular ROS in 4T1 cells after injection of BT-NS NPs, and (E) NIR-II FLI and PAI of tumors at different time points after injection of BT-NS NPs

Figure 4. (A) Design and biomedical application of ZSY-TPE, (B) design philosophy and preparation processes of DHTDP NP@M biomimetic nanoparticles, (C) NIR-II FLI and (D) PTI of mice tumors after intravenous injection of DHTDP-NP and DHTDP-NP@M, (E) design principle of DPBTA-DPTQ and the schematic diagram of its photophysical process after photoexcitation, and (F) NIR-II FLI and (G) PAI of HepG2 tumor-bearing mice after intravenous injection of DPBTA-DPTQ NPs at different monitoring times

Figure 5. (A) Fabrication process of BK@AIE NPs, (B) PTI images of mice brain after intravenous injection of BK@AIE NPs, (C) schematic of the design of a 980-nm excitable upconversion therapeutic nanoplatform UCNP@TTD-cRGD NPs based on AIE-emitting molecules, (D) FLI images of tumor-bearing mice after intravenous injection of UCNP@TTD-cRGD NPs

Figure 6. (A) Preparation process of BETT-2 NPs and its application in multimodal phototherapy to combat breast cancer, (B) NIR-II FLI and (C) PTI images of 4T1 tumor-bearing mice after intravenous administration of BETT-2 NPs, (D) PTI images 12 h post-injection of BETT-2 NPs and continuously irradiated by 1064 nm laser, (E) schematic diagram of NIR-II absorbing nanoparticles for tumor eradication in the NIR-II region, (F) relative temperature elevations of TPABT-TD NPs and ICG after penetrating chicken breast tissue of designed thicknesses, and (G) fluorescence images of TPABT-TD NPs with designed thickness of chicken tissues on top of the samples

Figure 7. (A) QM-B-CF for high signal-to-background imaging of tumors based on a sequential dual-lock CL strategy, (B) comparison FL and CL imaging of tumor-bearing mice, (C) schematic diagram of the preparation of TBL dots and the CL process, and (D) In vivo CL images of tumor-bearing mice after subcutaneous injection of TBL dots and 1O2

Figure 8. (A) Preparation process of DPA-TPE-SCP NPs, (B) Fluorescence images of intracellular ROS in 4T1 cells treated by DPA-TPE-SCP NPs and ultrasound, (C) fabrication of PAHN-1, and (D) comparison of tumour lung metastases in different treatment groups

Figure 9. (A) Schematic of ROS generation from pure organic TBDCR NPs under X-ray irradiation and (B) TBDCR NPs for X-PDT

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聚集诱导发光材料用于肿瘤光学诊疗

Aggregation-Induced Emission Materials for Tumor Phototheranostics

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