Chinese Journal of Organic Chemistry >
Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities
Received date: 2024-04-17
Revised date: 2024-05-27
Online published: 2024-07-10
Supported by
National Natural Science Foundation of China(82204275); National Natural Science Foundation of China(82160653); Hainan Provincial Natural Science Foundation(323MS014)
Normal-phase and reversed-phase silica gel column chromatography and semi-preparative high performance liquid chromatography were applied to study the chemical constituents of the stems and twigs of the Hainan mangrove plant, Excoecaria agallocha L. A new 3,4-seco-ent-kaurane diterpenoid, named agallochanin acid A (1), and a rare ent-tetranorlabdane diterpenoid, named agallochanin acid B (2), along with four known diterpenoids were isolated. Their structures including absolute configurations were characterized via HR-ESI-MS, extensive 1D and 2D NMR investigations and calculated and experimental electronic circular dichroism (ECD) data. All isolates were tested for their inhibitory effects on NO production in lipopolysaccharide (LPS)-activated BV-2 cells. ent-3,4-Seco-17-oxo-kaur-4(19),15(16)-dien-3-oic acid (3) and ent-15-hydroxy- labda-8(17),13E-dien-3-one (5) exhibited considerable anti-neuroinflammatory activities with IC50 values of (14.32±1.99) and (4.24±0.37) μmol/L.
Junyi Li , Lu Yang , Mingbin Chen , Yong Rao , Zhongping Jiang , Ling Huang . Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities[J]. Chinese Journal of Organic Chemistry, 2024 , 44(11) : 3526 -3530 . DOI: 10.6023/cjoc202404024
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