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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 12: 3686 - 3701

DOI: https://doi.org/10.6023/cjoc202405013

REVIEW

Recent Advances on the Synthesis and Application of α,α-Difluoro-β-aminophosphonates

  • Youlong Du ,
  • Qian Wang ,
  • Haibo Mei ,
  • Romana Pajkert ,
  • Gerd-Volker R?schenthaler ,
  • Jianlin Han
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  • a Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037
    b School of Science, Constructor University Bremen gGmbH, 28759 Bremen, Germany
*Corresponding authors. E-mail:;
;

Received date: 2024-05-13

  Revised date: 2024-06-22

  Online published: 2024-07-18

Supported by

National Natural Science Foundation of China(21761132021)

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Abstract

α,α-Difluoro-β-aminophosphonates can be looked as structural analogies with α-amino acids, which have attracted great attention in biological and medicinal chemistry during the past decades. Furthermore, these compounds also belong to an important type of organic building blocks for the rapid synthesis of difluoromethylenephosphonate-containing molecules. Thus, the preparation and application of α,α-difluoro-β-aminophosphonates are hot research topics in organic phosphine chemistry. A comprehensive summary of the literature reports related to α,α-difluoro-β-aminophosphonates in recent years is presented. And aspects of synthesis and applications of α,α-difluoro-β-aminophosphonates are discussed, in order to provide critical guidance for the further development of reactions and applications for the synthesis of difluoromethylenephosphonate derivatives.

Key words： aminophosphonate; α,α-difluoro-β-aminophosphonate; carbene; diazo compound; amine; bioactive compound

Cite this article

Youlong Du , Qian Wang , Haibo Mei , Romana Pajkert , Gerd-Volker R?schenthaler , Jianlin Han . Recent Advances on the Synthesis and Application of α,α-Difluoro-β-aminophosphonates[J]. Chinese Journal of Organic Chemistry, 2024 , 44(12) : 3686 -3701 . DOI: 10.6023/cjoc202405013

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