Recent Advances on the Synthesis and Application of α,α-Difluoro-β-aminophosphonates

doi:10.6023/cjoc202405013

Abstract

α,α-Difluoro-β-aminophosphonates can be looked as structural analogies with α-amino acids, which have attracted great attention in biological and medicinal chemistry during the past decades. Furthermore, these compounds also belong to an important type of organic building blocks for the rapid synthesis of difluoromethylenephosphonate-containing molecules. Thus, the preparation and application of α,α-difluoro-β-aminophosphonates are hot research topics in organic phosphine chemistry. This review presents a comprehensive summary of the literature reports related to α,α-difluoro-β-aminophosphonates in recent years. Aspects of synthesis and applications of α,α-difluoro-β-aminophosphonates are discussed. This review article will provide critical guidance for the further development of reactions and applications for the synthesis of difluoromethylenephosphonate derivatives.

Key words: aminophosphonates, α,α-difluoro-β-aminophosphonates, carbene, diazo compounds, amine

Cite this article

Youlong Du, Qian Wang, Haibo Mei, Romana Pajkert, Gerd-Volker Röschenthaler, Jianlin Han. Recent Advances on the Synthesis and Application of α,α-Difluoro-β-aminophosphonates[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202405013.

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