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Chinese Journal of Organic Chemistry >

0 202506022 - 202506022

DOI: https://doi.org/10.6023/cjoc202506022

REVIEW

Recent Progress in the Total Synthesis of abeo-Steroids

  • Zhao Lilin ,
  • Li Zhaoqi ,
  • Zhong Li-Ping ,
  • Min Long
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  • aCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China;
    b Department of Chemistry, Emory University, Atlanta, GA 30322, United States
#These authors contributed equally to this work.

Received date: 2025-06-17

  Revised date: 2025-07-24

  Online published: 2025-09-04

Supported by

National Natural Science Foundation of China (No. 22271137), the Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515010164).

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Abstract

Research on steroids play a significant role in organic chemistry, natural product medicinal chemistry, and drug discovery. To date, more than 100 steroidal drugs have been approved by FDA for the treatment of cancer, inflammation, pain, and heart failure. Recently, more and more abeo-steroids have been isolated. Due to their novel structures and important biological activities, abeo-steroids have attracted considerable attention from the synthetic community. In general, abeo-steroids are complex and diverse, containing a medium ring (seven-membered ring) or bridged ring system and possessing multiple stereogenic centers. All these structural features present considerable synthetic challenges. In this review, we summarized the latest progress in the total synthesis of abeo-steroids in the past eight years, focusing on the innovative synthetic strategies and methods. Finally, a brief outlook for the future development of abeo-steroids and related field is discussed.

Key words： steroid; abeo-steroid; total synthesis; seven-membered ring; bridged ring system

Cite this article

Zhao Lilin , Li Zhaoqi , Zhong Li-Ping , Min Long . Recent Progress in the Total Synthesis of abeo-Steroids[J]. Chinese Journal of Organic Chemistry, 0 : 202506022 -202506022 . DOI: 10.6023/cjoc202506022

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