Recent Progress in the Total Synthesis of abeo-Steroids

doi:10.6023/cjoc202506022

Chinese Journal of Organic Chemistry

REVIEW

abeo-甾体的全合成研究进展

赵礼麟^#,a, 李兆麒^#,a, 钟李平^*,b, 闵龙^*,a

^a深圳技术大学药学院深圳 518118;
^b埃默里大学化学系亚特兰大 30322

收稿日期:2025-06-17 修回日期:2025-07-24
基金资助:
国家自然科学基金(No. 22271137), 广东省基础与应用基础研究基金(No. 2021A1515010164)资助项目.

Recent Progress in the Total Synthesis of abeo-Steroids

Zhao Lilin^#,a, Li Zhaoqi^#,a, Zhong Li-Ping^*,b, Min Long^*a

^aCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China;
^b Department of Chemistry, Emory University, Atlanta, GA 30322, United States

Received:2025-06-17 Revised:2025-07-24
Contact: ^*E-mail: minlong@sztu.edu.cn; liping.zhong@emory.edu.
About author:^#These authors contributed equally to this work.
Supported by:
National Natural Science Foundation of China (No. 22271137), the Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515010164).

Research on steroids play a significant role in organic chemistry, natural product medicinal chemistry, and drug discovery. To date, more than 100 steroidal drugs have been approved by FDA for the treatment of cancer, inflammation, pain, and heart failure. Recently, more and more abeo-steroids have been isolated. Due to their novel structures and important biological activities, abeo-steroids have attracted considerable attention from the synthetic community. In general, abeo-steroids are complex and diverse, containing a medium ring (seven-membered ring) or bridged ring system and possessing multiple stereogenic centers. All these structural features present considerable synthetic challenges. In this review, we summarized the latest progress in the total synthesis of abeo-steroids in the past eight years, focusing on the innovative synthetic strategies and methods. Finally, a brief outlook for the future development of abeo-steroids and related field is discussed.

Key words: steroid, abeo-steroid, total synthesis, seven-membered ring, bridged ring system

Cite this article

Zhao Lilin, Li Zhaoqi, Zhong Li-Ping, Min Long. Recent Progress in the Total Synthesis of abeo-Steroids[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202506022.

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abeo-甾体的全合成研究进展

Recent Progress in the Total Synthesis of abeo-Steroids

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