Recent Progress in the Total Synthesis of abeo-Steroids

doi:10.6023/cjoc202506022

Chinese Journal of Organic Chemistry ›› 2026, Vol. 46 ›› Issue (1): 21-38.DOI: 10.6023/cjoc202506022 Previous Articles Next Articles

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abeo-甾体的全合成研究进展

赵礼麟^a^,^†, 李兆麒^a^,^†, 钟李平^b^,^*(), 闵龙^a^,^†()

^a 深圳技术大学药学院广东深圳 518118
^b 埃默里大学化学系亚特兰大 30322

收稿日期:2025-06-17 修回日期:2025-07-24 发布日期:2025-09-03
通讯作者: 钟李平
作者简介:
^† 共同第一作者
基金资助:
国家自然科学基金(22271137); 及广东省基础与应用基础研究基金(2021A1515010164)

Recent Progress in the Total Synthesis of abeo-Steroids

Zhao Lilin^a, Li Zhaoqi^a, Zhong Liping^b^,^*(), Min Long^a()

^a College of Pharmacy, Shenzhen Technology University, Shenzhen, Guangdong 518118, China
^b Department of Chemistry, Emory University, Atlanta, GA 30322, United States

Received:2025-06-17 Revised:2025-07-24 Published:2025-09-03
Contact: Zhong Liping
About author:
^† The authors contributed equally to this work
Supported by:
National Natural Science Foundation of China(22271137); Guangdong Basic and Applied Basic Research Foundation(2021A1515010164)

Research on steroids play a significant role in organic chemistry, medicinal chemistry of natural products, and drug discovery. To date, more than 100 steroidal drugs have been approved by U.S. Food and Drug Administration (FDA) for the treatment of cancer, inflammation, pain, and heart failure. Recently, more and more abeo-steroids have been isolated. Due to their novel structures and important biological activities, abeo-steroids have attracted considerable attention from the synthetic community. In general, abeo-steroids are complex and diverse, containing a medium ring (seven-membered ring) or bridged ring system and possessing multiple stereogenic centers. All these structural features present considerable synthetic challenges. The latest progress in the total synthesis of abeo-steroids in the past eight years is summarized, focusing on the innovative synthetic strategies and methods. Finally, a brief outlook for the future development of abeo-steroids and related field is discussed.

Key words: steroid, abeo-steroid, total synthesis, seven-membered ring, bridged ring system

Cite this article

Zhao Lilin, Li Zhaoqi, Zhong Liping, Min Long. Recent Progress in the Total Synthesis of abeo-Steroids[J]. Chinese Journal of Organic Chemistry, 2026, 46(1): 21-38.

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Fig. & Tab. 24

Figure 1. Selected FDA approved steroidal drugs (A) and selected abeo-steroids (B)

Figure 2. Structures of cyclocitrinol and selected members of cyclocitrinols

Scheme 1. Li’s asymmetric total synthesis of cyclocitrinol

Scheme 2. Gui’s ten-step synthesis of cyclocitrinol

Scheme 3. Gui’s unified synthesis of other nine cyclocitrinols

Figure 3. Structures of pleurocins A and B

Scheme 4. Heretsch’s asymmetric synthesis of pleurocin A (matsutakone) and pleurocin B

Figure 4. Structures of swinhoeisterol A, dankasterone A, dankasterone B and periconiastone A

Scheme 5. Heretsch’s asymmetric synthesis of swinhoeisterol A, dankasterone A, dankasterone B and periconiastone A

Scheme 6. Ma’s asymmetric total synthesis of dankasterone A, dankasterone B and periconiastone A

Scheme 7. Gui’s asymmetric total synthesis of swinhoeisterols A~C

Figure 5. Structure of bufospirostenin A

Scheme 8. Li’s asymmetric total synthesis of bufospirostenin A

Scheme 9. Gui’s asymmetric synthesis of bufospirostenin A

Scheme 10. Gui’s asymmetric synthesis of ophiopogonol A

Scheme 11. Yang’s asymmetric synthesis of bufospirostenin A

Figure 6. Structure of phomarol

Scheme 12. Li’s asymmetric total synthesis of phomarol

Scheme 13. Gui’s asymmetric total synthesis of phomarol

Figure 7. Structures of bufogargarizins A and B

Scheme 14. Li’s asymmetric total synthesis of bufogargarizin A

Scheme 15. Li’s asymmetric total synthesis of bufogargarizin B

Figure 8. Structure of aspersteroid A

Scheme 16. Gui’s asymmetric synthesis of aspersteroid A

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abeo-甾体的全合成研究进展

Recent Progress in the Total Synthesis of abeo-Steroids

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