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DOI: https://doi.org/10.6023/cjoc202507026

ARTICLE

Indium-Promoted Efficient Synthesis of Se-Aryl- 2,2-Dimethylbutaneselenoates

  • 杨凯 ,
  • 单申 ,
  • 陈伟铭 ,
  • 黄九忠 ,
  • 张毅 ,
  • 吴庆荣 ,
  • 吴高荣
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  • aJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou, 341000
    bDepartment of Pharmacy, Ganzhou Liver Institute, Ganzhou Fifth People's Hospital, Ganzhou 341000

Received date: 2025-07-19

  Revised date: 2025-09-23

  Online published: 2025-10-30

Supported by

Early-Career Young Scientists and Technologists Project of Jiangxi Province (No. 20244BCE52224), Jiangxi Provincial Natural Science Foundation (No. 20252BAC200240).

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Abstract

Selenoester compounds exhibit significant biological activity and are widely used in the synthesis of natural products, protein intermediates, and superconducting materials. However, current methods for constructing selenoesters suffer from drawbacks such as expensive catalysts, multiple reaction steps, low yields, and poor efficiency to sterically hindered acyl chlorides. Here, an efficient indium-promoted method for the synthesis of Se-aryl-2,2-dimethylbutaneselenoates is developed. The strategy features broad substrate scope, mild reaction conditions and simple operation, offering the desired products in moderate to excellent yields. Furthermore, the gram-scale reaction can be conducted smoothly, laying the foundation for subsequent derivatization of such structures.

Key words： organoselenium compounds; indium-promoted; Se-aryl-2,2-dimethylbutaneselenoates

Cite this article

杨凯 , 单申 , 陈伟铭 , 黄九忠 , 张毅 , 吴庆荣 , 吴高荣 . Indium-Promoted Efficient Synthesis of Se-Aryl- 2,2-Dimethylbutaneselenoates[J]. Chinese Journal of Organic Chemistry, 0 : 0 . DOI: 10.6023/cjoc202507026

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