ARTICLE

Copper-catalyzed Cyclization Reaction of 3-Nitrochromenes with Enaminones to Synthesize of 2H-Chromeno-pyrrole Derivatives

  • Wanting Liang ,
  • Siyi Chen ,
  • Enqi Xu ,
  • Xue-Bing Chen
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  • aSchool of Chemistry and Resource Engineering Honghe University, Yunnan Province International Joint Laboratory of Green Food (China-Vietnam), Mengzi, Yunnan 661199

Received date: 2025-07-28

  Revised date: 2025-09-25

  Online published: 2025-11-05

Supported by

Yunnan Province International Joint Laboratory of Green Food (China-Vietnam) (No.202403AP140032).

Abstract

Chromeno-pyrrole derivatives exhibit a wide range of biological and pharmacological activities. Herein, a novel approach to the synthesis of molecular diversity 2H-chromeno-pyrrole has been developed from [3+2] cyclization of 3-nitrochromenes with cyclic β-enaminones catalyzed by CuI, and DBN as the promoter at room temperature. This reaction has the advantages of good functional group compatibility, broad substrate universality, and mild reaction conditions.

Cite this article

Wanting Liang , Siyi Chen , Enqi Xu , Xue-Bing Chen . Copper-catalyzed Cyclization Reaction of 3-Nitrochromenes with Enaminones to Synthesize of 2H-Chromeno-pyrrole Derivatives[J]. Chinese Journal of Organic Chemistry, 0 : 0 . DOI: 10.6023/cjoc202507037

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