Copper-catalyzed Cyclization Reaction of 3-Nitrochromenes with Enaminones to Synthesize of 2H-Chromeno-pyrrole Derivatives

doi:10.6023/cjoc202507037

Abstract

Chromeno-pyrrole derivatives exhibit a wide range of biological and pharmacological activities. Herein, a novel approach to the synthesis of molecular diversity 2H-chromeno-pyrrole has been developed from [3+2] cyclization of 3-nitrochromenes with cyclic β-enaminones catalyzed by CuI, and DBN as the promoter at room temperature. This reaction has the advantages of good functional group compatibility, broad substrate universality, and mild reaction conditions.

Key words: copper catalyzed, [3+2] cyclization, 2H-chromeno-pyrroles, 3-nitrochromenes, enaminones

Cite this article

Wanting Liang, Siyi Chen, Enqi Xu, Xue-Bing Chen. Copper-catalyzed Cyclization Reaction of 3-Nitrochromenes with Enaminones to Synthesize of 2H-Chromeno-pyrrole Derivatives[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202507037.

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铜催化3-硝基色烯与烯胺酮环化反应合成2H-色烯并吡咯衍生物