ARTICLE

Visible-Light-Induced Phosphorylation Cyclization to Phosphorylated Indole-Fused Diazepines

  • Xinyi Hou ,
  • Tongtong Shi ,
  • Zejiang Li ,
  • Qinghao Dong ,
  • Kai Sun ,
  • Xin Wang
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  • aCollege of Chemistry and Materials Science, Hebei University, Baoding, Hebei, 071002, P. R. China;
    bSchool of Pharmacy, Yantai University, Yantai, Shandong, 264005, P. R. China

Received date: 2025-09-25

  Revised date: 2025-10-20

  Online published: 2025-11-11

Supported by

Project supported by the National Natural Science Foundation of China (22301259); Shandong Provincial Natural Science Foundation (ZR2023MB135; ZR2024QB086).

Abstract

A novel visible-light induced phosphorylation cyclization to indole-fused medium-sized diazepines was established under room temperature. Broad substrates scope, good functional group compatibility, large-scale synthesis and derivatization via nitration, chlorination and cyanation demonstrate the utility of this protocol. P-centered radical involed energy transfer (EnT) process was proposed based on radical inhibition experiments, visible-light irradiation on-off test, AQE calculation, UV-vis absorption spectroscopic studies and cyclic voltammetry experiments.

Cite this article

Xinyi Hou , Tongtong Shi , Zejiang Li , Qinghao Dong , Kai Sun , Xin Wang . Visible-Light-Induced Phosphorylation Cyclization to Phosphorylated Indole-Fused Diazepines[J]. Chinese Journal of Organic Chemistry, 0 : 202509032 -202509032 . DOI: 10.6023/cjoc202509032

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