Visible-Light-Induced Phosphorylation Cyclization to Phosphorylated Indole-Fused Diazepines

doi:10.6023/cjoc202509032

Abstract

A novel visible-light induced phosphorylation cyclization to indole-fused medium-sized diazepines was established under room temperature. Broad substrates scope, good functional group compatibility, large-scale synthesis and derivatization via nitration, chlorination and cyanation demonstrate the utility of this protocol. P-centered radical involed energy transfer (EnT) process was proposed based on radical inhibition experiments, visible-light irradiation on-off test, AQE calculation, UV-vis absorption spectroscopic studies and cyclic voltammetry experiments.

Key words: Photocatalysis, Radical cyclization, Phosphorylation, Medium-sized N-heterocycles

Cite this article

Xinyi Hou, Tongtong Shi, Zejiang Li, Qinghao Dong, Kai Sun, Xin Wang. Visible-Light-Induced Phosphorylation Cyclization to Phosphorylated Indole-Fused Diazepines[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202509032.

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可见光催化的磷酰化环化合成磷酰基取代的吲哚并二氮草