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Chinese Journal of Organic Chemistry >

0 123004 - 123004

DOI: https://doi.org/10.6023/cjoc202510004

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Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes

  • 沈国礼 ,
  • 何玥 ,
  • 景士文 ,
  • 安子博 ,
  • 徐丹丹
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  • aCollege of Chemical Engineering and technology, Tianshui Normal University, Tianshui 741001;
    bKey Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Tianshui 741001;
    cKey Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui 741001

Received date: 2025-10-10

  Revised date: 2025-11-16

  Online published: 2025-12-30

Supported by

Youth Science and Technology Foundation of Gansu (No. 25JRRE011), the Youth Innovation and Entrepreneurship Talent Project of Gansu Province (No. 2025QNTD08), the Tianshui Normal University (No. KYQ2023-12、No. GJB2024-01).

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Abstract

Transition metal-catalyzed asymmetric cyclization reactions of 1,3-dienes represent a powerful strategy for the construction of chiral cyclic compounds, with broad applications in the synthesis of natural products, pharmaceuticals, and functional materials. This article systematrically reviews recent advances in this field, focusing on two major cyclization modes 1,2-and 1,4-cyclication, and provides a detailed discussions, including Heck reactions, C-H bond activation, Wacker-type oxidations, and π-Lewis base catalysis. These methods enable efficient and highly enantioselective construction of various ring systems ranging from five-to eight-membered cycles, demonstrating good functional group compatibility and substrate diversity. Despite significant progress, challenges remain, such as unclear mechanisms, limited substrate scope, and insufficient stereocontrol . Future developments should focus on in-depht mechanistic elucidation, the design of economical metal catalysts, and the expansion of substrate generality to enhance the utility of these transformations.

Key words： Transition metal; 1,3-Dienes; Asymmetric cyclization

Cite this article

沈国礼 , 何玥 , 景士文 , 安子博 , 徐丹丹 . Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes[J]. Chinese Journal of Organic Chemistry, 0 : 123004 -123004 . DOI: 10.6023/cjoc202510004

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