Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes

doi:10.6023/cjoc202510004

Chinese Journal of Organic Chemistry

REWIEW

过渡金属催化1,3-二烯的不对称环化反应研究进展

沈国礼^*,a,b,c, 何玥^a, 景士文^a, 安子博^a,b,c, 徐丹丹^*,a

^a天水师范大学化学工程与技术学院天水 741001;
^b甘肃省先进光电功能材料重点实验室天水 741001;
^c甘肃省高校新型分子材料设计与功能省级重点实验室天水 741001

收稿日期:2025-10-10 修回日期:2025-11-16
基金资助:
甘肃省青年科技基金(No. 25JRRE011),陇原青年创新创业人才(No. 2025QNTD08),天水师范大学(No. KYQ2023-12、No. GJB2024-01)资助项目.

Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes

Shen, Guoli^*,a,b,c, He, Yue^a, Jing, Shiwen^a, An, Zibo^a,b,c, Xu, Dandan^*,a

^aCollege of Chemical Engineering and technology, Tianshui Normal University, Tianshui 741001;
^bKey Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Tianshui 741001;
^cKey Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui 741001

Received:2025-10-10 Revised:2025-11-16
Contact: ^*E-mail: shenguoli0208@163.com, 18837053307@163.com
Supported by:
Youth Science and Technology Foundation of Gansu (No. 25JRRE011), the Youth Innovation and Entrepreneurship Talent Project of Gansu Province (No. 2025QNTD08), the Tianshui Normal University (No. KYQ2023-12、No. GJB2024-01).

Transition metal-catalyzed asymmetric cyclization reactions of 1,3-dienes represent a powerful strategy for the construction of chiral cyclic compounds, with broad applications in the synthesis of natural products, pharmaceuticals, and functional materials. This article systematrically reviews recent advances in this field, focusing on two major cyclization modes 1,2-and 1,4-cyclication, and provides a detailed discussions, including Heck reactions, C-H bond activation, Wacker-type oxidations, and π-Lewis base catalysis. These methods enable efficient and highly enantioselective construction of various ring systems ranging from five-to eight-membered cycles, demonstrating good functional group compatibility and substrate diversity. Despite significant progress, challenges remain, such as unclear mechanisms, limited substrate scope, and insufficient stereocontrol . Future developments should focus on in-depht mechanistic elucidation, the design of economical metal catalysts, and the expansion of substrate generality to enhance the utility of these transformations.

Key words: Transition metal, 1,3-Dienes, Asymmetric cyclization

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Shen, Guoli, He, Yue, Jing, Shiwen, An, Zibo, Xu, Dandan. Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202510004.

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过渡金属催化1,3-二烯的不对称环化反应研究进展

Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes

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