Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes

doi:10.6023/cjoc202510004

Abstract

Transition metal-catalyzed asymmetric cyclization reactions of 1,3-dienes represent a powerful strategy for the construction of chiral cyclic compounds, with broad applications in the synthesis of natural products, pharmaceuticals, and functional materials. The recent advances in this field are systematically reviewed, focusing on two major cyclization modes: 1,2- and 1,4-cyclication. Detailed discussions are provided, including Heck reactions, C—H bond activation, Wacker-type oxidations, and π-Lewis base catalysis. These methods enable efficient and highly enantioselective construction of various ring systems ranging from five to eight membered cycles, demonstrating good functional group compatibility and substrate diversity. Despite considerable advances, several challenges still persist, including ambiguous reaction mechanisms, narrow substrate scope, and poor stereocontrol. Future developments should focus on in-depth mechanistic elucidation, the design of economical metal catalysts, and the expansion of substrate generality to enhance the utility of these transformations.

Key words: transition metal, 1,3-diene, asymmetric cyclization

Cite this article

Guoli Shen, Yue He, Shiwen Jing, Zibo An, Dandan Xu. Research Progress on Transition Metal-Catalyzed Asymmetric Cyclization Reactions of 1,3-Dienes[J]. Chinese Journal of Organic Chemistry, 2026, 46(5): 1916-1938.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

Fig. & Tab. 41

Scheme 1. Transition metal-catalyzed asymmetric cyclization reactions of 1,3-dienes (framework of this review)

Scheme 2. Transition metal-catalyzed Heck/Tsuji-Trost cyclization reactions of 1,3-dienes

Scheme 3. Pd-catalyzed Heck/Tsuji-Trost cyclization reaction of 1,3-dienes with aryl iodides

Scheme 4. Pd-catalyzed asymmetric Heck/Tsuji-Trost cyclization of 1,3-dienes with 2-iodoarenes

Scheme 5. Pd-catalyzed Heck/Tsuji-Trost cyclization of 1,3-dienes for the construction of spirocyclic compounds

Scheme 6. Pd/Sadphos-catalyzed asymmetric Heck/Tsuji-Trost cyclization of 2-bromophenol with 1,3-dienes

Scheme 7. Pd/Sadphos-catalyzed asymmetric Heck/Tsuji-Trost cyclization of 1,3-cyclohexadienes with iodoallylic alcohols

Scheme 8. Pd/Chiral anion catalyzed asymmetric Heck/Tsuji-Trost cyclization reaction

Scheme 9. Pd-catalyzed as Heck/Tsuji-Trost cyclization of 1,3-dienes with benzotriazoles

Scheme 10. Pd-catalyzed radical-relay Heck/Tsuji-Trost annulation of haloalkylamines with 1,3-dienes

Scheme 11. Pd-catalyzed radical-relay Heck/Tsuji-Trost annulation of haloamides with 1,3-dienes

Scheme 12. Pd-catalyzed radical-relay Heck/Tsuji-Trost annulation of indoles with 1,3-dienes

Scheme 13. Transition-metal-catalyzed annulation of 1,3-dienes via C—H activation

Scheme 14. Pd(II)-catalyzed cyclative carboamidation of arylureas with 1,3-dienes

Scheme 15. Pd(II)-catalyzed asymmetric C—H activation annulation of indoles with 1,3-dienes

Scheme 16. Pd(II)-catalyzed intramolecular cascade reaction of indole derivatives intiated by C—H activation

Scheme 17. Rh(III)-catalyzed enantioselective cyclization of 1,3-dienes via C—H activation

Scheme 18. Ir(I)-catalyzed asymmetric C—H activation/annulation of imines with 1,3-dienes

Scheme 19. Sc-catalyzed asymmetric C—H activation/annulation of imines with 1,3-dienes

Scheme 20. Pd(II)-catalyzed Wacker-type cyclization of 1,3- dienes

Scheme 21. Pd(II)-catalyzed cyclization of 1,3-dienes with ureas

Scheme 22. Pd(II)-catalyzed cyclization of 1,3-dienes with 1,2-diaminobenzene

Scheme 23. Pd(II)-catalyzed asymmetric cyclization of 1,3-dienes with ureas

Scheme 24. Pd(II)-catalyzed asymmetric cyclization of 1,3-dienes with phenols

Scheme 25. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of 1,3-dienes

Scheme 26. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of 1,3-dienes with aldimines

Scheme 27. Asymmetric cyclization of 1,3-dienes enabled by Pd(0)-π-Lewis base/amine relay catalysis

Scheme 28. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of 1,3-dienes with α-ketoamides

Scheme 29. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of 1,3-dienes with 2-formylbenzeneboronic acids

Scheme 30. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of electron-deficient 1,3-dienes with 1-azadienes

Scheme 31. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of 1,3-cyclohexadienes with 1-azadienes

Scheme 32. Ni-catalyzed cyclization of 1,3-dienes with 1,1-dichloroalkenes

Scheme 33. Ni-catalyzed asymmetric cyclization of 1,3-dienes with 1,1-dichloroalkenes

Scheme 34. Ni-catalyzed asymmetric cyclization of 1,3-dienes with 1,2-dichlordisilanes

Scheme 35. Rh-catalyzed asymmetric cyclization of 1,3-dienes with dialkyl acetylenedicarboxylate

Scheme 36. Co-catalyzed asymmetric cyclization of 1,3-dienes with alkynes

Scheme 37. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of 1,3-dienes with N-CN-imines

Scheme 38. Ni-catalyzed asymmetric cyclization of 1,3-dienes with dichlorodisilanes

Scheme 39. Ni-catalyzed enantioselective reductive [4＋2] cyclization of 1,3-dienes with chlorosilanes

Scheme 40. Fe-catalyzed asymmetric [4＋4] cyclization of 1,3-dienes

Scheme 41. Pd(0)-π-Lewis base catalyzed asymmetric cyclization of 1,3-dienes with azadienes

References 52

[1]	(a) Eschenbrenner-Lux V.; Kumar K.; Waldmann H. Angew. Chem., Int. Ed. 2014, 53, 11146. doi: 10.1002/anie.v53.42 pmid: 29936839
	(b) Olivares A. M.; Weix D. J. J. Am. Chem. Soc. 2018, 140, 2446. doi: 10.1021/jacs.7b13601 pmid: 29936839
	(c) Nguyen V. T.; Dang H. T.; Pham H. H.; Nguyen V. D.; Flores-Hansen C.; Arman H. D.; Larionov O. V. J. Am. Chem. Soc. 2018, 140, 8434. doi: 10.1021/jacs.8b05421 pmid: 29936839
	(d) Hu T.-J.; Li M.-Y.; Zhao Q.; Feng C.-G.; Lin G.-Q. Angew. Chem., Int. Ed. 2018, 57, 5871. doi: 10.1002/anie.v57.20 pmid: 29936839
	(e) Long J.; Liu B.; Zhang S.; Zhu Y.; Gu S. Chin. J. Org. Chem. 2024, 44, 3309 (in Chinese). doi: 10.6023/cjoc202403021 pmid: 29936839
	(龙姣, 刘白雪, 张双双, 朱园园, 古双喜, 有机化学, 2024, 44, 3309.) doi: 10.6023/cjoc202403021 pmid: 29936839
[2]	(a) Wang X.; Gong L.-Z. Synthesis 2019, 51, 122. doi: 10.1055/s-0037-1610379
	(b) Sigman M. S.; Werner E. W. Acc. Chem. Res. 2012, 45, 874. doi: 10.1021/ar200236v
	(c) Wu Z.; Zhang W. Chin. J. Org. Chem. 2017, 37, 2250 (in Chinese). doi: 10.6023/cjoc201704031
	(吴正兴, 张万斌, 有机化学, 2017, 37, 2250.) doi: 10.6023/cjoc201704031
	(d) Zhu X.-Q.; Wang Q.; Zhu J. Angew. Chem., Int. Ed. 2023, 62, e202214925. doi: 10.1002/anie.v62.1
[3]	(a) Hoyt J. M.; Schmidt V. A.; Tondreau A. M.; Chirik P. J. Science 2015, 349, 960. doi: 10.1126/science.aac7440 pmid: 23351145
	(b) Kim H.; Kim S.; Kim J.; Son J. Y.; Baek Y.; Um K.; Lee P. H. Org. Lett. 2017, 19, 5677. doi: 10.1021/acs.orglett.7b02826 pmid: 23351145
	(c) Lang B.; Zhu H.; Wang C.; Lu P.; Wang Y. Org. Lett. 2017, 19, 1630. doi: 10.1021/acs.orglett.7b00438 pmid: 23351145
	(d) Kim S.; Kim H.; Um K.; Lee P. H. J. Org. Chem. 2017, 82, 9808. doi: 10.1021/acs.joc.7b01150 pmid: 23351145
	(e) Chen Z.-C.; Ouyang Q.; Du W.; Chen Y.-C. J. Am. Chem. Soc. 2024, 146, 6422. doi: 10.1021/jacs.3c14674 pmid: 23351145
	(f) Tu Y.; Xu B.; Wang Q.; Dong H.; Zhang Z.-M.; Zhang J. J. Am. Chem. Soc. 2023, 145, 4378. doi: 10.1021/jacs.2c12752 pmid: 23351145
	(g) Nishimura T.; Ebe Y.; Hayashi T. J. Am. Chem. Soc. 2013, 135, 2092. doi: 10.1021/ja311968d pmid: 23351145
	(h) Nishimura T.; Nagamoto M.; Ebe Y.; Hayashi T. Chem. Sci. 2013, 4, 4499. doi: 10.1039/c3sc52379a pmid: 23351145
[4]	O’ Connor, J. M.; Stallman, B. J.; Clark, W. G.; Shu, A. Y. L.; Spada, R. E.; Stevenson, T. M.; Dieck, H. A. J. Org. Chem. 1983, 48, 807. doi: 10.1021/jo00154a010
[5]	Larock R. C.; Fried C. A. J. Am. Chem. Soc. 1990, 112, 5882. doi: 10.1021/ja00171a040
[6]	Hong C. Y.; Overman L. E. Tetrahedron Lett. 1994, 35, 3453. doi: 10.1016/S0040-4039(00)73208-4
[7]	(a) Kagechika K.; Shibasaki M. J. Org. Chem. 1991, 56, 4093. doi: 10.1021/jo00013a004 pmid: 20725641
	(b) Kagechika K.; Ohshima T.; Shibasaki M. Tetrahedron 1993, 49, 1773. doi: 10.1016/S0040-4020(01)80534-2 pmid: 20725641
	(c) Ohshima T.; Kagechika K.; Adachi M.; Sodeoka M.; Shibasaki M. J. Am. Chem. Soc. 1996, 118, 7108. doi: 10.1021/ja9609359 pmid: 20725641
	(d) Overman L. E.; Rosen M. D. Tetrahedron 2010, 66, 6514. doi: 10.1016/j.tet.2010.05.048 pmid: 20725641
	(e) Overman L. E.; Rosen M. D. Angew. Chem., Int. Ed. 2000, 39, 4596. doi: 10.1002/(ISSN)1521-3773 pmid: 20725641
	(f) Flubacher D.; Helmchen G. Tetrahedron Lett. 1999, 40, 3867. doi: 10.1016/S0040-4039(99)00628-0 pmid: 20725641
	(g) Wu X.; Lin H.-C.; Li M.-L.; Li L.-L.; Han Z.-Y.; Gong L.-Z. J. Am. Chem. Soc. 2015, 137, 13476. doi: 10.1021/jacs.5b08734 pmid: 20725641
[8]	Chen S.-S.; Meng J.; Li Y.-H.; Han Z.-Y. J. Org. Chem. 2016, 81, 9402. doi: 10.1021/acs.joc.6b01611
[9]	Wu X.; Chen S.-S.; Sen; Zhang L.; Wang H.-J.; Gong L.-Z. Chem. Commun. 2018, 54, 9595. doi: 10.1039/C8CC04641G
[10]	Luo L.; Zheng H.; Liu J.; Wang H.; Wang Y.; Luan X. Org. Lett. 2016, 18, 2082. doi: 10.1021/acs.orglett.6b00710
[11]	Zhang Y.; Pan Z.; Guo H.; Yang J.; Zhang J. Tetrahedron Lett. 2022, 107, 154120. doi: 10.1016/j.tetlet.2022.154120
[12]	Zhang L.-Z.; Zhang P.-C.; Wang Q.; Zhou M.; Zhang J. Nat. Commun. 2025, 16, 930. doi: 10.1038/s41467-025-56142-z
[13]	Xu J.-C.; Yin Y.-Z.; Han Z.-Y. Org. Lett. 2021, 23, 3834. doi: 10.1021/acs.orglett.1c00910
[14]	Wang Y.; Li Y.; Fan Y.; Wang Z.; Tang Y. Chem. Commun. 2017, 53, 11873. doi: 10.1039/C7CC07543J
[15]	Li Y.-L.; Zhang P.-C.; Wu H.-H.; Zhang J. J. Am. Chem. Soc. 2021, 143, 13010. doi: 10.1021/jacs.1c07212
[16]	(a) Huang H.-M.; Koy M.; Serrano E.; Pflüger P. M.; Schwarz J. L.; Glorius F. Nat. Catal. 2020, 3, 393. doi: 10.1038/s41929-020-0434-0
	(b) Cheung K. P. S.; Kurandina D.; Yata T.; Gevorgyan V. J. Am. Chem. Soc. 2020, 142, 9932. doi: 10.1021/jacs.0c03993
	(c) Huang H.-M.; Bellotti P.; Pflüger P. M.; Schwarz J. L.; Glorius F. J. Am. Chem. Soc. 2020, 142, 9932. doi: 10.1021/jacs.0c03993
	(d) Song S.; Yin Y.-Z.; Han Z.-Y. Synth. 2023, 55, 3793. doi: 10.1055/a-2122-1573
	(e) Liu Z.-L.; Yan J.-L.; Chen K.; Xiang H.-Y.; Yang H. Org. Lett. 2024, 26, 8762. doi: 10.1021/acs.orglett.4c03080
	(f) Liu Z.-L.; Ye Z.-P.; Liao Z.-H.; Lu W.-D.; Guan J.-P.; Gao Z.-Y.; Chen K.; Chen X.-Q.; Xiang H.-Y.; Yang H. ACS Catal. 2024, 14, 3725. doi: 10.1021/acscatal.4c00470
[17]	Zheng Y.; Lu W.; Xie Z.; Chen K.; Xiang H.; Yang H. Org. Lett. 2022, 24, 5407. doi: 10.1021/acs.orglett.2c02101 pmid: 35848222
[18]	Singh A.; Pal K.; Dutta S.; Dey A.; Kancherla R.; Maity B.; Cavallo L.; Rueping M. Angew. Chem., Int. Ed. 2025, 64, e202503446. doi: 10.1002/anie.v64.30
[19]	Zhan X.; Nie Z.; Li N.; Zhou A.; Lv H.; Liang M.; Wu K.; Xheng G.-J.; Yin Q. Angew. Chem., Int. Ed. 2024, 63, e202404388. doi: 10.1002/anie.v63.26
[20]	(a) Newton C. G.; Wang S. G.; Oliveira C. C.; Cramer N. Chem. Rev. 2017, 117, 8908. doi: 10.1021/acs.chemrev.6b00692 pmid: 33491691
	(b) Engle K. M.; Mei T.-S.; Wasa M.; Yu J.-Q. Acc. Chem. Res. 2012, 45, 788. doi: 10.1021/ar200185g pmid: 33491691
	(c) Yeung C. S.; Dong V. M. Chem. Rev. 2011, 111, 1215. doi: 10.1021/cr100280d pmid: 33491691
	(d) Lyons T. W.; Sanford M. S. Chem. Rev. 2010, 110, 1147. doi: 10.1021/cr900184e pmid: 33491691
	(e) Zhang J.; Lu X.; Shen C.; Xu L.; Ding L.; Zhong G. Chem. Soc. Rev. 2021, 50, 3263. doi: 10.1039/d0cs00447b pmid: 33491691
	(f) Rej S.; Ano Y.; Chatani N. Chem. Rev. 2020, 120, 1788. doi: 10.1021/acs.chemrev.9b00495 pmid: 33491691
	(g) Ackermann L. Acc. Chem. Res. 2020, 53, 84. doi: 10.1021/acs.accounts.9b00510 pmid: 33491691
[21]	Houlden C. E.; Bailey C. D.; Ford J. G.; Gagne M. R.; Lloyd-Jones G. C.; Booker-Milburn K. I. J. Am. Chem. Soc. 2008, 130, 10066. doi: 10.1021/ja803397y pmid: 18613664
[22]	Chen S.-S.; Wu M.-S.; Han Z.-Y. Angew. Chem., Int. Ed. 2017, 56, 6641. doi: 10.1002/anie.v56.23
[23]	Zhang T.; Shen H.-C.; Xu J.-C.; Fan T.; Han Z.-Y.; Gong L.-Z. Org. Lett. 2019, 21, 2048. doi: 10.1021/acs.orglett.9b00216 pmid: 30901225
[24]	(a) Cooper S. P.; Booker-Milburn K. I. Angew. Chem., Int. Ed. 2015, 54, 6496. doi: 10.1002/anie.v54.22
	(b) Watt M. S.; Booker-Milburn K. I. Org. Lett. 2016, 18, 5716. doi: 10.1021/acs.orglett.6b02947
[25]	Wu L.; Li L.; Zhang H.; Gao H.; Zhou Z.; Yi W. Org. Lett. 2021, 23, 3844. doi: 10.1021/acs.orglett.1c00945
[26]	Mishra A.; Cong X.; Nishiura M.; Hou Z. J. Am. Chem. Soc. 2023, 145, 17468. doi: 10.1021/jacs.3c06482
[27]	(a) Zhu Y.; Cornwall R. G.; Du H.; Zhao B.; Shi Y. Acc. Chem. Res. 2014, 47, 3665. doi: 10.1021/ar500344t pmid: 21428440
	(b) McDonald R. I.; Liu G.; Stahl S. S. Chem. Rev. 2011, 111, 2981. doi: 10.1021/cr100371y pmid: 21428440
	(c) Cardona F.; Goti A. Nat. Chem. 2009, 1, 269. doi: 10.1038/nchem.256 pmid: 21428440
[28]	Lucet D.; Le Gall T.; Mioskowski C. Angew. Chem., Int. Ed. 1998, 37, 2580. doi: 10.1002/(ISSN)1521-3773
[29]	Bar G. L. J.; Lloyd-Jones G. C.; Booker-Milburn K. I. J. Am. Chem. Soc. 2005, 127, 7308. doi: 10.1021/ja051181d
[30]	(a) Du H.; Zhao B.; Yuan W.; Shi Y. Org. Lett. 2008, 19, 2813. doi: 10.1021/acs.orglett.7b00919
	(b) Zhao B.; Peng X.; Cui S.; Shi Y. J. Am. Chem. Soc. 2010, 132, 11009. doi: 10.1021/ja103838d
[31]	Wu Z.; Wen K.; Zhang J.; Zhang W. Org. Lett. 2017, 10, 4231. doi: 10.1021/ol801605w
[32]	Wu M.-S.; Fan T.; Chen S.-S.; Han Z.-Y.; Gong L.-Z. Org. Lett. 2018, 20, 2485. doi: 10.1021/acs.orglett.8b00870
[33]	Shen H.-C.; Wu Y.-F.; Zhang Y.; Fan L.-F.; Han Z.-Y.; Gong L.-Z. Angew. Chem., Int. Ed. 2018, 57, 2372. doi: 10.1002/anie.v57.9
[34]	Fan T.; Shen H.-C.; Han Z.-Y.; Gong L.-Z. Chin. J. Chem. 2019, 37, 226. doi: 10.1002/cjoc.v37.3
[35]	Xiao B.-X.; Jiang B.; Yan R.-J.; Zhu J.-X.; Xie K.; Gao X.-Y.; Ouyang Q.; Du W.; Chen Y.-C. J. Am. Chem. Soc. 2021, 143, 4809. doi: 10.1021/jacs.1c01420
[36]	Lu J.-B.; Liang S.-Y.; Gui W.-T.; Chen Z.-C.; Du W.; Chen Y.-C. Org. Lett. 2023, 25, 576. doi: 10.1021/acs.orglett.2c03762
[37]	Shen G.-L.; Tan Y.-Y; Hu Y.; Chen Z.-C.; Du W.; Chen Y.-C. Org. Lett. 2023, 25, 6649. doi: 10.1021/acs.orglett.3c02443
[38]	Liang S.-Y.; Zhang T.-Y.; Chen Z.-C.; Du W.; Chen Y.-C. Org. Lett. 2024, 26, 1483 doi: 10.1021/acs.orglett.4c00160
[39]	Xie K.; Kong B.-R.; Wang C.-Q.; Chen Z.-C.; Du W.; Chen Y.-C. Org. Lett. 2025, 27, 7058. doi: 10.1021/acs.orglett.5c01957
[40]	Hu Y.; Huang J.-Y.; Yan R.-J.; Chen Z.-C.; Ouyang Q.; Du W.; Chen Y.-C. Chem. Sci. 2023, 14, 1896. doi: 10.1039/D2SC06813C
[41]	(a) Ishihara K.; Kondo S.; Yamamoto H.; Ohashi H.; Inagaki S. J. Org. Chem. 1997, 62, 3026. pmid: 18494473
	(b) Corey E. J.; Lee T. W. Tetrahedron Lett. 1997, 38, 5755. doi: 10.1016/S0040-4039(97)01287-2 pmid: 18494473
	(c) Evans D. A.; Miller S. J.; Lectka T.; von Matt P. J. Am. Chem. Soc. 1999, 121, 7559. doi: 10.1021/ja991190k pmid: 18494473
	(d) Hilt G.; Hess W.; Harms K. Org. Lett. 2006, 8, 3287. doi: 10.1021/ol061153f pmid: 18494473
	(e) Ishihara K.; Fushimi M. J. Am. Chem. Soc. 2008, 130, 7532. doi: 10.1021/ja8015318 pmid: 18494473
	(f) Hatano M.; Sakamoto T.; Mizuno T.; Goto Y.; Ishihara K. J. Am. Chem. Soc. 2018, 140, 16253. doi: 10.1021/jacs.8b09974 pmid: 18494473
[42]	(a) Barluenga J.; Lopez S.; Florez J. Angew. Chem., Int. Ed. 2003, 42, 231. doi: 10.1002/anie.v42:2
	(b) Chen J.-R.; Hu X.-Q.; Lu L.-Q.; Xiao W.-J. Chem. Rev. 2015, 115, 5301. doi: 10.1021/cr5006974
[43]	Zhou Y.-Y.; Uyeda C. Science 2019, 363, 857. doi: 10.1126/science.aau0364
[44]	Behlen M. J.; Uyeda C. J. Am. Chem. Soc. 2020, 142, 17294. doi: 10.1021/jacs.0c08262
[45]	Qi L.; Pan Q.-Q.; Wei X.-X.; Pang X.; Liu Z.; Shu X.-Z. J. Am. Chem. Soc. 2023, 145, 13008. doi: 10.1021/jacs.3c04209
[46]	Bao L.-Y.; Yin J.; Shi L.; Zheng L. Org. Biomol. Chem. 2020, 18, 2956. doi: 10.1039/D0OB00361A
[47]	Singh D.; RajanBabu T. V. Angew. Chem., Int. Ed. 2023, 62, e202216000. doi: 10.1002/anie.v62.8
[48]	Zhang J.; Hu Y.; Zhang T.-Y.; Chen Z.-C.; Du W.; Chen Y.-C. Org. Lett. 2023, 25, 8133. doi: 10.1021/acs.orglett.3c03261 pmid: 37933993
[49]	Qi L.; Xu S.; Pang X.; Wu Y.-K.; Wang X.; Shu X.-Z. Angew. Chem., Int. Ed. 2025, 64, e202509961. doi: 10.1002/anie.v64.35
[50]	Yin K.; Yang L.-Y.; Chen S.; Zhao D. Angew. Chem., Int. Ed. 2025, 64, e202515185.
[51]	Braconi E.; Götzinger A. C.; Cramer N. J. Am. Chem. Soc. 2020, 142, 19819. doi: 10.1021/jacs.0c09486 pmid: 33175501
[52]	Pan J.; Ogawa Ho T.; Chen Y.-C.; Yang B.-M.; Zhao Y. Angew. Chem., Int. Ed. 2024, 63, e202317703. doi: 10.1002/anie.v63.6

过渡金属催化1,3-二烯的不对称环化反应研究进展