Chemical investigation on a marine-derived fungus Talaromyces sp. F017-1-114 led to isolation of two new xanthone derivatives (1 and 2), one new bisabolane-type sesquiterpene (3), and six known polyhydroxanthones (4-9). The structures of the new compounds were demonstrated by HRESIMS, extensive NMR investigations, single-crystal X-ray diffraction analysis with Cu Kα radiation, and electronic circular dichroism (ECD) calculations. Among them, compounds 5 and 6 showed moderate antimicrobial activities against Ralstonia solanacearum ATCC11696 with MIC values of 25 and 12.5 µg/mL, respectively. Compound 3 exhibited weak antibacterial activity against Staphylococcus aureus ATCC25923 with an MIC value of 50 µg/mL.
He Yong
,
Zhang Yaya
,
Fu Lin
,
Deng Lunan
,
Chen Guangying
,
Li Wanshan
. Research on Secondary Metabolites and Antibacterial Activity of a Marine-derived Fungus Talaromyces sp. F017-1-114[J]. Chinese Journal of Organic Chemistry, 0
: 202604035
-202604035
.
DOI: 10.6023/cjoc202604035
[1] Ren X.; Xie X.; Chen B.; Liu L.; Jiang C.; Qian, Q. J. Med. Chem. 2021, 64, 7879.
[2] Morales-Oyervides L.; Ruiz-Sánchez J. P.; Oliveira J. C.; Sousa-Gallagher M. J.; Méndez-Zavala A.; Giuffrida D.; Dufossé L.; Montañez J. Biotechnol. Adv. 2020, 43, 107601.
[3] Quan C.; Wu Z.; Hu G.; Shu Y.; Peng X.; Qiu M. Food Chem. 2025, 503, 147791.
[4] Carroll A. R.; Copp B. R.; Grkovic T.; Keyzers R. A.; Prinsep, M. R. Nat. Prod. Rep. 2026, 43, 89.
[5] Ma X. Y.; Wang H. N.; Sun L. X.; Sun J.; Jin S. H.; Dai F. X.; Sai C. M.; Zhang, Z. J. Asian Nat. Prod. Res. 2025, 27, 1236.
[6] Sun B. D.; Chen A. J.; Houbraken J.; Frisvad J. C.; Wu W. P.; Wei H. L.; Zhou Y. G.; Jiang X. Z.; Samson R. A. MycoKeys. 2020, 68, 75.
[7] Nicoletti R.; Salvatore M. M.; Andolfi A. Mar. Drugs2018, 16, 12.
[8] Wang W.; Wang J.; Song F.; Jia R.; Wang L.; Xu X.; Yang N. Mar. Drugs2024, 22, 237.
[9] Zhu H. Q.; Feng S.; Xie R. K.; Zhu Z. T.; Lou Y. H.; Zhou X. M.; Song X. M.Chem. Biodivers. 2024, 21, e202400937.
[10] El-Elimat T.; Figueroa M.; Raja H. A.; Graf T. N.; Swanson S. M.; Falkinham III J. O.; Wani M. C.; Pearce C. J.; Oberlies, N. H. Eur. J. Org. Chem. 2015, 2015, 109.
[11] Stoll A.; Renz J.; Brack A.Helv. Chim. Acta. 1952, 35, 2022.
[12] Lv H.; Su H.; Xue Y.; Jia J.; Bi H.; Wang S.; Zhang J.; Zhu M.; Emam M.; Wang H.; Hong K.; Li, X. N. Mar. Life Sci. Technol. 2023, 5, 232.
[13] Li H. L.; Li X. M.; Liu H.; Meng L. H.; Wang, B. G. Mar. Drugs. 2016, 14, 223.
[14] Xue J.; Li H.; Wu P.; Xu L.; Yuan Y.; Wei, X. J. Nat. Prod. 2020, 83, 1480.
[15] Yong K.; Kaleem S.; Yi W.; Wu B.; Zhang Z. Tetrahedron Lett. 2021, 81, 153354.
[16] Lünne F.; Köhler J.; Stroh C.; Müller L.; Daniliuc C. G.; Mück-Lichtenfeld C.; Wurthwein E. U.; Esselen M.; Humpf H. U.; Kalinina, S. A. J. Nat. Prod. 2021, 84, 2630.
[17] Cheng T.; Chepkirui C.; Decock C.; Matasyoh J. C.; Stadler, M. J. Nat. Prod. 2019, 82, 1283.
[18] Zhang F.; Ma C.; Wang W.; Zhu M.; Zhang G.; Zhu T.; Che Q.; Li D. Org. Lett. 2025, 27, 7482.
[19] Wu Z.; Zhang G.; Tian S.; Wang L.; Dong Y.; Li Y.; Wang H.Waste Manag. 2026, 211, 115279.
[20] Lei L. R.; Gong L. Q.; Jin M. Y.; Wang R.; Liu R.; Gao J.; Liu M. D.; Huang L.; Wang G. Z.; Wang D.; Deng Y.Front. Microbiol. 2022, 13, 984801.
[21] Ling L.; Han X. Y.; Li X.; Zhang X.; Wang H.; Zhang L.; Cao P.; Wu Y.; Wang X.; Zhao J.; Xiang W.Microorganisms 2020, 8, 351.
