Research on Secondary Metabolites and Antibacterial Activity of a Marine-derived Fungus Talaromyces sp. F017-1-114

doi:10.6023/cjoc202604035

Chinese Journal of Organic Chemistry

ARTICLE

海洋来源真菌Talaromyces sp. F017-1-114次级代谢产物与其抗菌活性研究

何勇^a,b, 张亚亚^a,b, 符霖^a,b, 邓璐楠^a,b, 陈光英^*,a,b, 黎婉珊^*,a,b

^a热带药用资源化学教育部重点实验室,海南师范大学化学与化工学院海口 571158;
^b热带药用植物化学海南省重点实验室,海南师范大学化学与化工学院海口 571158

收稿日期:2026-04-23 修回日期:2026-05-24
基金资助:
国家自然科学基金(No. 22267006)、海南省自然科学基金 (No. 222QN303)、大学生创新创业训练计划 (No. S202511658012) 资助项目.

Research on Secondary Metabolites and Antibacterial Activity of a Marine-derived Fungus Talaromyces sp. F017-1-114

He Yong^a,b, Zhang Yaya^a,b, Fu Lin^a,b, Deng Lunan^a,b, Chen Guangying^*,a,b, Li Wanshan^*,a,b

^aKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, People’s Republic of China;
^bKey Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, People’s Republic of China

Received:2026-04-23 Revised:2026-05-24
Contact: *E-mail: liwanshan@hainnu.edu.cn
Supported by:
National Natural Science Foundation of China (No.22267006), Hainan Provincial Natural Science Foundation of China (No. 222QN303) and Innovation and Entrepreneurship Training Program for College students (No. S202511658012).

1. .pdf(2206KB)

Abstract

Chemical investigation on a marine-derived fungus Talaromyces sp. F017-1-114 led to isolation of two new xanthone derivatives (1 and 2), one new bisabolane-type sesquiterpene (3), and six known polyhydroxanthones (4-9). The structures of the new compounds were demonstrated by HRESIMS, extensive NMR investigations, single-crystal X-ray diffraction analysis with Cu Kα radiation, and electronic circular dichroism (ECD) calculations. Among them, compounds 5 and 6 showed moderate antimicrobial activities against Ralstonia solanacearum ATCC11696 with MIC values of 25 and 12.5 µg/mL, respectively. Compound 3 exhibited weak antibacterial activity against Staphylococcus aureus ATCC25923 with an MIC value of 50 µg/mL.

Key words: Talaromyces sp, Marine-derived fungi, Xanthones, Sesquiterpenes, Antibacterial activity

Cite this article

He Yong, Zhang Yaya, Fu Lin, Deng Lunan, Chen Guangying, Li Wanshan. Research on Secondary Metabolites and Antibacterial Activity of a Marine-derived Fungus Talaromyces sp. F017-1-114[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202604035.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

References

[1] Ren X.; Xie X.; Chen B.; Liu L.; Jiang C.; Qian, Q. J. Med. Chem. 2021, 64, 7879.
[2] Morales-Oyervides L.; Ruiz-Sánchez J. P.; Oliveira J. C.; Sousa-Gallagher M. J.; Méndez-Zavala A.; Giuffrida D.; Dufossé L.; Montañez J. Biotechnol. Adv. 2020, 43, 107601.
[3] Quan C.; Wu Z.; Hu G.; Shu Y.; Peng X.; Qiu M. Food Chem. 2025, 503, 147791.
[4] Carroll A. R.; Copp B. R.; Grkovic T.; Keyzers R. A.; Prinsep, M. R. Nat. Prod. Rep. 2026, 43, 89.
[5] Ma X. Y.; Wang H. N.; Sun L. X.; Sun J.; Jin S. H.; Dai F. X.; Sai C. M.; Zhang, Z. J. Asian Nat. Prod. Res. 2025, 27, 1236.
[6] Sun B. D.; Chen A. J.; Houbraken J.; Frisvad J. C.; Wu W. P.; Wei H. L.; Zhou Y. G.; Jiang X. Z.; Samson R. A. MycoKeys. 2020, 68, 75.
[7] Nicoletti R.; Salvatore M. M.; Andolfi A. Mar. Drugs2018, 16, 12.
[8] Wang W.; Wang J.; Song F.; Jia R.; Wang L.; Xu X.; Yang N. Mar. Drugs2024, 22, 237.
[9] Zhu H. Q.; Feng S.; Xie R. K.; Zhu Z. T.; Lou Y. H.; Zhou X. M.; Song X. M.Chem. Biodivers. 2024, 21, e202400937.
[10] El-Elimat T.; Figueroa M.; Raja H. A.; Graf T. N.; Swanson S. M.; Falkinham III J. O.; Wani M. C.; Pearce C. J.; Oberlies, N. H. Eur. J. Org. Chem. 2015, 2015, 109.
[11] Stoll A.; Renz J.; Brack A.Helv. Chim. Acta. 1952, 35, 2022.
[12] Lv H.; Su H.; Xue Y.; Jia J.; Bi H.; Wang S.; Zhang J.; Zhu M.; Emam M.; Wang H.; Hong K.; Li, X. N. Mar. Life Sci. Technol. 2023, 5, 232.
[13] Li H. L.; Li X. M.; Liu H.; Meng L. H.; Wang, B. G. Mar. Drugs. 2016, 14, 223.
[14] Xue J.; Li H.; Wu P.; Xu L.; Yuan Y.; Wei, X. J. Nat. Prod. 2020, 83, 1480.
[15] Yong K.; Kaleem S.; Yi W.; Wu B.; Zhang Z. Tetrahedron Lett. 2021, 81, 153354.
[16] Lünne F.; Köhler J.; Stroh C.; Müller L.; Daniliuc C. G.; Mück-Lichtenfeld C.; Wurthwein E. U.; Esselen M.; Humpf H. U.; Kalinina, S. A. J. Nat. Prod. 2021, 84, 2630.
[17] Cheng T.; Chepkirui C.; Decock C.; Matasyoh J. C.; Stadler, M. J. Nat. Prod. 2019, 82, 1283.
[18] Zhang F.; Ma C.; Wang W.; Zhu M.; Zhang G.; Zhu T.; Che Q.; Li D. Org. Lett. 2025, 27, 7482.
[19] Wu Z.; Zhang G.; Tian S.; Wang L.; Dong Y.; Li Y.; Wang H.Waste Manag. 2026, 211, 115279.
[20] Lei L. R.; Gong L. Q.; Jin M. Y.; Wang R.; Liu R.; Gao J.; Liu M. D.; Huang L.; Wang G. Z.; Wang D.; Deng Y.Front. Microbiol. 2022, 13, 984801.
[21] Ling L.; Han X. Y.; Li X.; Zhang X.; Wang H.; Zhang L.; Cao P.; Wu Y.; Wang X.; Zhao J.; Xiang W.Microorganisms 2020, 8, 351.

海洋来源真菌Talaromyces sp. F017-1-114次级代谢产物与其抗菌活性研究

Research on Secondary Metabolites and Antibacterial Activity of a Marine-derived Fungus Talaromyces sp. F017-1-114

PDF

Supporting Info.

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Liping Dong, Jinhua Yang, Rong Fang, Xing Zhang, Xiaoqiang Zhu, Xiaobin Bi, Liang Lei. Study on the Secondary Metabolites and Antibacterial Activity of a Fungus Aspergillus sp. L06 from the Roots of Stelleropsis tianschanica (Pobed) [J]. Chinese Journal of Organic Chemistry, 2026, 46(6): 2482-2486.
[2]	Huixian She, Qing Wang, Qin Zha, Jiaqiang Yang. Design, Synthesis and Antibacterial Activities of Isoxzoleamide Derivatives Containing Phosphonate Fragment [J]. Chinese Journal of Organic Chemistry, 2026, 46(5): 2059-2066.
[3]	Tao Zhang, Zhenyu Ji, Gongli Tang, Xianfeng Hou. Discovery of A New Sesquiterpene-Lactone from Streptomyces aureus SP-371 [J]. Chinese Journal of Organic Chemistry, 2026, 46(2): 689-692.
[4]	Jueying Shi, Yikang Qiu, Jing Lan, Zhenyang Xu, Yi Wang, Jiaxiang Li, Youping Luo, Guolei Huang, Caijuan Zheng. Research on Secondary Metabolites from a Mangrove-Derived Fungus Penicillium janthinellum XLN32122 and Their Biological Activities [J]. Chinese Journal of Organic Chemistry, 2026, 46(2): 678-683.
[5]	Dongyang Guo, Jingxian Cong, Maosheng Zhang, Minjian Dong, Guangxiang Liang, Chengxin Sun, Wenxi Wu, Shiji Xiao. A Rare Sesquiterpene from Hawk Tea [J]. Chinese Journal of Organic Chemistry, 2025, 45(9): 3486-3489.
[6]	Hong Xiao, Yuyue Qin, Shuo Chen, Fuling Cen, Zhuansheng Gao, Wanshan Li, Guangying Chen. Research on Sesquiterpenoids from a Marine-Derived Fungus Phellinus sp. HN-22 and Their Anti-inflammatory Activities [J]. Chinese Journal of Organic Chemistry, 2025, 45(8): 3033-3038.
[7]	Xiong Qiu, Huijuan Li, Yanling Tang, Yaojun Xu, Na Li, Xiaoli Li, Xingjie Zhang, Weilie Xiao. One New Guaianolide Sesquiterpenoid with Potential Anti-inflammatory Activity from Ainsliaea glabra. [J]. Chinese Journal of Organic Chemistry, 2025, 45(8): 3028-3032.
[8]	Jiaqiang Yang, Xurong Zhou, Yangmi Chen, Huixian She. Synthesis and Antibacterial Activities of Osthole Derivatives Containing Phosphonateptide Fragment [J]. Chinese Journal of Organic Chemistry, 2025, 45(4): 1306-1314.
[9]	Limin Wang, Xiaoyu Song, Senxiang Cheng, Tong Chen, Deyun Cui. Synthesis and Activity Study of 1,2-Benzisothiazol-3-one Derivatives [J]. Chinese Journal of Organic Chemistry, 2024, 44(6): 1897-1906.
[10]	Lingdong Li, Weilun Zhang, Pengfei Liu, Zijie Zhou, Hao Zhou, Zhongtian Du. Synthesis of Gemini-Quaternary Ammonium N-Chloramine Biocides for Antibacterial Applications [J]. Chinese Journal of Organic Chemistry, 2024, 44(6): 2041-2048.
[11]	Yanmei Wei, Zhangxin Yu, Yiyi Du, Pingshu Wang, Fuling Cen, Xiaobao Li, Guangying Chen. Studies on the Highly Oxidized Cadinane Sesquiterpenes from Alangium salviifolium and Their Bioactivities [J]. Chinese Journal of Organic Chemistry, 2024, 44(4): 1363-1367.
[12]	Jiaqiang Yang, Xuejiao Wu, Zicong Lu, Yangmi Chen, Huixian She, Haijun Liu. Design, Synthesis and Antibacterial Activities of Osthole Derivatives Containing Thiazole Fragment [J]. Chinese Journal of Organic Chemistry, 2024, 44(11): 3541-3549.
[13]	Weizhong Ding, Bingwen Zhang, Yanqing Xue, Yuqi Lin, Zhijun Tang, Jing Wang, Wenchao Yang, Xiaofeng Wang, Wen Liu. A New Polyketide from Fusarium graminearum [J]. Chinese Journal of Organic Chemistry, 2023, 43(9): 3319-3322.
[14]	Xiurong Wu, Chaojiang Xiao, Yi Shen, Hongxia Tang, Junyi Zhu, Bei Jiang. Research Progress on Antimalarial Natural Sesquiterpenoids from Plants from 1972 to 2022 [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2764-2789.
[15]	Feng Wang, Yu Chen, Hongyan Pei, Jing Zhang, Lixin Zhang. Design, Synthesis and Antifungal Activities of Novel 1,2,4-Oxadiazole Derivatives Containing Piperidine [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2826-2836.