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DOI: https://doi.org/10.6023/cjoc202607014

REVIEW

Research Progress in Catalytic Asymmetric Electrophilic Disulfuration Reactions

  • Li Ze-Long ,
  • Ke Hua ,
  • Chen Zhi-Min
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  • a Shanghai Key Laboratory of Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240;
    b Engineering Technology Research Center for Environmental Protection Materials, Pingxiang University, Pingxiang, 337055;
    c State Key Laboratory of Polyolefins and Catalysis, Shanghai Research Institute of Chemical Industry Co., Ltd., Shanghai, 200062

Received date: 2026-07-15

  Revised date: 2026-08-11

  Online published: 2026-08-28

Supported by

National Natural Science Foundation of China (No. 22471158), autonomous Project of State Key Laboratory of Synergistic Chem-Bio Synthesis (No. sklscbs202562), the project of State Key Laboratory of Polyolefins and Catalysis (No. SKLZX-2025-10).

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Abstract

Disulfides are widely used in life sciences, medicinal chemistry, and functional materials, and also serve as important intermediates in the synthesis of organosulfur compounds. Among them, chiral disulfides have shown significant potential in chiral pharmaceuticals and asymmetric catalysis, making their efficient construction an important yet challenging task in synthetic chemistry. Catalytic asymmetric electrophilic disulfuration provides a direct and efficient approach to chiral disulfides, featuring high catalytic efficiency and operational simplicity. In recent years, catalytic asymmetric electrophilic disulfuration strategies based on different electrophilic disulfurating reagents have begun to emerge, enabling the enantioselective synthesis of structurally diverse disulfides. This review classifies these reactions according to the types of electrophilic disulfurating reagents and summarizes the structural features of these reagents, their substrate compatibility, the origins of enantioselectivity, and the further transformations of the resulting chiral disulfides. Finally, the current challenges in this field are discussed, and future development prospects are outlined.

Key words： disulfuration; electrophilic reaction; asymmetric catalysis

Cite this article

Li Ze-Long , Ke Hua , Chen Zhi-Min . Research Progress in Catalytic Asymmetric Electrophilic Disulfuration Reactions[J]. Chinese Journal of Organic Chemistry, 0 : 0 . DOI: 10.6023/cjoc202607014

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