Activity-guided and DeepSAT analyses on the antifungal constituents of Streptomyces sp. 444, isolated from the Hoh Xil region, led to the discovery of two new antimycin analogs, deformyl-antimycin A10a (1) and antimycin A1c (2), along with two known analogs, antimycin A3a (3) and antimycin A8a (4). The structures of these antimycin analogs were elucidated by high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS), nuclear magnetic resonance (NMR), and NMR calculations. Bioassay indicated that compounds 1-4 exhibited antifungal activity. The MIC values of compound 2 against Candida albicans ATCC 10231 and Cryptococcus neoformans H99, determined by the broth microdilution method, were 4 and 8 μg/mL, respectively.
An Junliu
,
Xu Jixiang
,
Pang Kun
,
Yang Xinyi
,
Sun Chenghang
,
Yuan Lijie
. Study on the Antifungal Constituents from Hoh Xil-Derived Streptomyces sp. 444[J]. Chinese Journal of Organic Chemistry, 0
: 202604020
-202604020
.
DOI: 10.6023/cjoc202604020
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