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Chinese Journal of Organic Chemistry >

0 202608018 - 202608018

DOI: https://doi.org/10.6023/cjoc202608018

ARTICLE

Rongalite as C1 synthon for 1,4,5-Trisubstituted Imidazole Synthesis via [3+1+1] Cyclization

  • Fachuan Zhu ,
  • Yunyun Liu ,
  • Chengfeng Wan ,
  • Wen-Bo Zhang ,
  • Jieping Wan
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  • aCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang, 330022;
    bInternational Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing, 210037;
    cHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219

Received date: 2026-08-18

  Revised date: 2026-09-03

  Online published: 2026-09-16

Supported by

National Natural Science Foundation of China (No. 22561026) and Jiangxi Provincial Natural Science Foundation (20262BAC250114).

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Abstract

Reported herein is an efficient and green one-pot, three-component cyclization tactic for imidazole synthesis. With cheap rongalite as C1 synthon to react with 2H-azirines and amines, a series of 1,4,5-trisubstituted imidazoles have been synthesized in green EtOH medium. The work represents the first example on imidazole synthesis with rongalite as C1 synthon. Comparing with traditional method using aldehyde C1 synthon, rongalite displays evidently expanded tolerance to different types of substrates in the current work, enabling the synthesis of imidazole with rather broad scope.

Key words： cyclization; rongalite; imidazole; arylation

Cite this article

Fachuan Zhu , Yunyun Liu , Chengfeng Wan , Wen-Bo Zhang , Jieping Wan . Rongalite as C1 synthon for 1,4,5-Trisubstituted Imidazole Synthesis via [3+1+1] Cyclization[J]. Chinese Journal of Organic Chemistry, 0 : 202608018 -202608018 . DOI: 10.6023/cjoc202608018

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