Rongalite as C1 synthon for 1,4,5-Trisubstituted Imidazole Synthesis via [3+1+1] Cyclization

doi:10.6023/cjoc202608018

Chinese Journal of Organic Chemistry

ARTICLE

雕白粉作为一碳合成子的[3+1+1]环化合成1,4,5-三取代咪唑

朱法川^a, 刘云云^*,a, 万常峰^a, 张闻博^c, 万结平^*,a,b

^a江西师范大学化学与材料学院南昌 330022;
^b南京林业大学林产化学与材料国际创新高地南京 210037;
^c长沙医学院功能核酸基础与临床湖南省普通高校重点实验室长沙 410219

收稿日期:2026-08-18 修回日期:2026-09-03 发布日期:2026-09-14
基金资助:
国家自然科学基金(No. 22561026)和江西省自然科学基金(20262BAC250114)资助项目.

Rongalite as C1 synthon for 1,4,5-Trisubstituted Imidazole Synthesis via [3+1+1] Cyclization

Fachuan Zhu^a, Yunyun Liu^*,a, Chengfeng Wan^a, Wen-Bo Zhang^c, Jieping Wan^*,a,b

^aCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang, 330022;
^bInternational Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing, 210037;
^cHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219

Received:2026-08-18 Revised:2026-09-03 Published:2026-09-14
Contact: *E-mail: chemliuyunyun@jxnu.edu.cn; wanjieping@jxnu.edu.cn
Supported by:
National Natural Science Foundation of China (No. 22561026) and Jiangxi Provincial Natural Science Foundation (20262BAC250114).

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Abstract

Reported herein is an efficient and green one-pot, three-component cyclization tactic for imidazole synthesis. With cheap rongalite as C1 synthon to react with 2H-azirines and amines, a series of 1,4,5-trisubstituted imidazoles have been synthesized in green EtOH medium. The work represents the first example on imidazole synthesis with rongalite as C1 synthon. Comparing with traditional method using aldehyde C1 synthon, rongalite displays evidently expanded tolerance to different types of substrates in the current work, enabling the synthesis of imidazole with rather broad scope.

Key words: cyclization, rongalite, imidazole, arylation

Cite this article

Fachuan Zhu, Yunyun Liu, Chengfeng Wan, Wen-Bo Zhang, Jieping Wan. Rongalite as C1 synthon for 1,4,5-Trisubstituted Imidazole Synthesis via [3+1+1] Cyclization[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202608018.

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雕白粉作为一碳合成子的[3+1+1]环化合成1,4,5-三取代咪唑

Rongalite as C1 synthon for 1,4,5-Trisubstituted Imidazole Synthesis via [3+1+1] Cyclization

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