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Chinese Journal of Organic Chemistry >

0 202605017

DOI: https://doi.org/10.6023/cjoc202605017

ARTICLE

Four New Carboxyl-Substituted Phenylpropanoic acid Derivatives from the Leaves of Plumeria rubra L.

  • De-Cai Dai ,
  • Xue-Feng Xu ,
  • Hao Yan ,
  • Yu Zhang
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  • aHainan Vocational University of Science and Technology ,School of Chemistry and Materials Engineering, Haikou, People’s Republic of China, Haikou, 571126, People’s Republic of China

Received date: 2026-05-16

  Revised date: 2026-08-14

  Online published: 2026-09-22

Supported by

Hainan Vocational University of Science and Technology Scientific Research Project (No. HKKY2021ZD-05).

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Abstract

Four new carboxyl-substituted phenylpropanoic acid derivatives, named plumeriapropionics F-I (1-4), were isolated from the leaves of Plumeria rubra L. Compounds 1-4 are rare carboxyl-substituted phenylpropanoic acid derivatives, and fewer than 10 analogues of this type have been reported so far. Their absolute configurations were determined by electronic circular dichroism (ECD) calculations. We evaluated the inhibitory effects of plumeriapropionics F-I on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells in vitro. Compounds 1-4 showed potent inhibitory activities, with IC50 values ranging from 5.12 ± 0.08 to 38.29 ± 0.10 μM. For comparison, the positive control indomethacin exhibited an IC50 value of 25.11 ± 0.09 μM against NO production.

Key words： Plumeria rubra; Phenylpropanoic acid derivatives; Anti-inflammatory activity

Cite this article

De-Cai Dai , Xue-Feng Xu , Hao Yan , Yu Zhang . Four New Carboxyl-Substituted Phenylpropanoic acid Derivatives from the Leaves of Plumeria rubra L.[J]. Chinese Journal of Organic Chemistry, 0 : 202605017 . DOI: 10.6023/cjoc202605017

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