Four New Carboxyl-Substituted Phenylpropanoic acid Derivatives from the Leaves of Plumeria rubra L.

doi:10.6023/cjoc202605017

Chinese Journal of Organic Chemistry

ARTICLE

鸡蛋花叶中四个新的羧基取代苯丙酸衍生物

代德财^*,a, 徐雪峰^a, 闫浩^a, 张玉^a

^a海南科技职业大学化学与材料工程学院海口 571126

收稿日期:2026-05-16 修回日期:2026-08-14
基金资助:
海南科技职业大学资助项目 (编号. HKKY2021ZD-05).

Four New Carboxyl-Substituted Phenylpropanoic acid Derivatives from the Leaves of Plumeria rubra L.

De-Cai Dai^*,a, Xue-Feng Xu^a, Hao Yan^a, Yu Zhang^a

^aHainan Vocational University of Science and Technology ,School of Chemistry and Materials Engineering, Haikou, People’s Republic of China, Haikou, 571126, People’s Republic of China

Received:2026-05-16 Revised:2026-08-14
Contact: ^*E-mail: 254958816@qq.com
Supported by:
Hainan Vocational University of Science and Technology Scientific Research Project (No. HKKY2021ZD-05).

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Abstract

Four new carboxyl-substituted phenylpropanoic acid derivatives, named plumeriapropionics F-I (1-4), were isolated from the leaves of Plumeria rubra L. Compounds 1-4 are rare carboxyl-substituted phenylpropanoic acid derivatives, and fewer than 10 analogues of this type have been reported so far. Their absolute configurations were determined by electronic circular dichroism (ECD) calculations. We evaluated the inhibitory effects of plumeriapropionics F-I on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells in vitro. Compounds 1-4 showed potent inhibitory activities, with IC₅₀ values ranging from 5.12 ± 0.08 to 38.29 ± 0.10 μM. For comparison, the positive control indomethacin exhibited an IC₅₀ value of 25.11 ± 0.09 μM against NO production.

Key words: Plumeria rubra, Phenylpropanoic acid derivatives, Anti-inflammatory activity

Cite this article

De-Cai Dai, Xue-Feng Xu, Hao Yan, Yu Zhang. Four New Carboxyl-Substituted Phenylpropanoic acid Derivatives from the Leaves of Plumeria rubra L.[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202605017.

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鸡蛋花叶中四个新的羧基取代苯丙酸衍生物

Four New Carboxyl-Substituted Phenylpropanoic acid Derivatives from the Leaves of Plumeria rubra L.

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