化学学报 ›› 2012, Vol. 70 ›› Issue (12): 1362-1366.DOI: 10.6023/A1201143 上一篇    下一篇

研究论文

银掺杂纳米羟基磷灰石抗菌粉体的水热合成及结构表征

陈华军, 徐伏秋, 薛冬, 阳永福, 张秋芬   

  1. 洛阳理工学院 环境工程与化学系 洛阳 471023
  • 收稿日期:2012-01-14 修回日期:2012-04-16 出版日期:2012-06-28 发布日期:2012-04-20
  • 通讯作者: 陈华军 E-mail:chj790118@163.com
  • 基金资助:

    国家自然科学基金(No. 41101222)和河南省教育厅自然科学研究基金(No. 2006430025)资助项目.

Hydrothermal Synthesis and Characterization of Ag-doped Hydroxyapatite Antibacterial Agent

Chen Huajun, Xu Fuqiu, Xue Dong, Yang Yongfu, Zhang Qiufen   

  1. Department of Environment and Chemistry, Luoyang Institute of Science and Technology, Luoyang 471023
  • Received:2012-01-14 Revised:2012-04-16 Online:2012-06-28 Published:2012-04-20
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 41101222) and Henan Provincial Natural Science Research Funds (No. 2006430025).

采用水热法, 以硝酸钙(Ca(NO3)2?4H2O)、硝酸银(AgNO3)和磷酸氢二铵((NH4)2HPO4)为主要原料, 制备纳米级银掺杂羟基磷灰石(Ag-HA)抗菌粉体. 考察了硝酸银加入量、反应温度、反应时间对产物结构和形貌的影响. XRD 分析结果显示Ag-HA 与HA 具有相同的晶体结构. EDS 和XRF 分析结果说明Ag+取代Ca2+在HA 晶体中的位置, 生成AgxCa10-x(PO4)6(OH)2. 抗菌试验结果表明, 所制备的Ag-HA抗菌粉体具有良好的抗菌性能, 最小抑菌浓度MIC 值≤50μg/mL (对大肠杆菌、黄色葡萄球菌).

关键词: 银-羟基磷灰石, 固溶体, 水热合成, 结构表征, 抗菌性

Silver doped hydroxyapatite (HA) antimicrobial powders were synthesized by hydrothermal method using Ca(NO3)2?4H2O, AgNO3, (NH4)2HPO4 as raw materials. The effects of addition of AgNO3, reactive temperature and time on the microstructure and constituent of Ag-HA were investigated. The XRD patterns indicate that HA and Ag-HA have the same crystal structure. The calculation results of energy dispersive spectrometer (EDS) and X-ray fluorescence spectrum (XRF) indicate that Ca2+ in HA crystals is displaced by Ag+ and AgxCa10-x(PO4)6(OH)2 was produced at hydrothermal condition. The antibacterial test results indicate that Ag-HA have favourable antibiotic property and MIC≤50 μg/mL against Escherichia coli and Staphylococcus aureus.

Key words: Ag-HA, solid solution, hydrothermal method, characterization, antibiotic property