### 甲氨蝶呤/层状双金属氢氧化物的粒径调控及缓释性能研究

1. 江苏省生物功能材料重点实验室 南京师范大学化学与材料科学学院 南京 210097
• 投稿日期:2012-03-25 发布日期:2012-08-23
• 通讯作者: 李淑萍 E-mail:lishuping@njnu.edu.cn
• 基金资助:

项目受国家自然科学基金(No. 21073093)、高等学校博士点专项科研基金(No. 20103207120006)和江苏高校优势学科建设工程资助.

### Controllable Synthesis and Release Properties of Methotrexatum/Layered Double Hydroxide Compounds

Qi Fenglin, Li Shuping, Zhang Xiaoqing

1. Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China
• Received:2012-03-25 Published:2012-08-23
• Supported by:

Project supported by the National Natural Science Foundation of China (No. 21073093), Research Fund for the Doctoral Program of Higher Education of China (No. 20103207120006) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

The methotrexatum/layered double hydroxide (MTX/LDH) compounds with different particle sizes were prepared by controlling the dropping speed of precipitator, using the coprecipitation method in alcohol-water solvent and NH32O as precipitator. The influence of the dropping speed of precipitator on the structure and morphologies of MTX/LDHs was systematically characterized by X-ray diffraction (XRD), transmission electron micrograph (TEM) and fourier transform infrared spectroscopy (FT-IR). The results indicated that MTX anions were intercalated into the LDH interlayers with a declined monolayer and the angle of inclination changed with the variation of the dropping speed of precipitator. Furthermore, the dropping speed of precipitator affected the crystallinity and particle size as well as arrangement way of MTX in LDH interlayers, when the dropping speed is 0.100 mL/s, the products have the highest crystallinity and the maximum diameter. All the MTX/LDHs particles exhibited hexagonal platelet morphology with round corner and good monodispersity. At last, the release properties of MTX/LDHs with different particle sizes were studied in phosphate buffer. The results indicated that the smaller nanoparticles have higher drug-loading capacity than those of the larger ones and when the angles of inclination keep almost constant, the smaller nanoparticles have the longer release time than those of the larger ones. In addition, four kinetic models (first-order equation, Higuchi equation, Bhaskar equation and Ritger-Peppas equation) were used to study the release kinetics of MTX from the LDH interlayers, and it was found that the mechanism for drug release can be well described by the Ritger-Peppas equation, revealing that the release mechanism of MTX/LDH belongs to drug diffusion and Fickian diffusion is the rate limiting step. First of all, we have explored a new way to synthesize LDH compounds with different particle size in the guarantee of the angles of inclination of anions in interlayer keeping similar.