化学学报 ›› 2019, Vol. 77 ›› Issue (12): 1230-1238.DOI: 10.6023/A19070262 上一篇    下一篇

综述

DNA-二维纳米片层材料传感平台的构建及其应用

迟景元, 李晶, 任少康, 苏邵, 汪联辉   

  1. 南京邮电大学 材料科学与工程学院 有机电子与信息显示国家重点实验室培育基地江苏省生物传感材料与技术重点实验室 南京 210023
  • 投稿日期:2019-07-12 发布日期:2019-09-18
  • 通讯作者: 汪联辉 E-mail:iamlhwang@njupt.edu.cn
  • 作者简介:迟景元,南京邮电大学材料科学与工程学院2017级在读本科生,研究方向为纳米生物传感器的构建及其应用;苏邵,南京邮电大学材料科学与工程学院副教授,硕士生导师.主要从事纳米生物传感器的构建及其在肿瘤标志物分析检测中的应用研究;汪联辉,南京邮电大学材料科学与工程学院教授,博士生导师,长期从事光电纳米材料、生物光电子学、纳米生物医学等领域研究工作.
  • 基金资助:
    项目受国家重点研发计划纳米科技重点专项(No.2017YFA0205302)、国家自然科学基金(Nos.61671250,21475064)和江苏省大学生创新训练计划(No.SZD2018013)资助.

Construction and Application of DNA-two-dimensional Layered Nanomaterials Sensing Platform

Chi Jingyuan, Li Jing, Ren Shaokang, Su Shao, Wang Lianhui   

  1. Key Laboratory for Organic Electronics and Information Displays(KLOEID) & Jiangsu Key Laboratory for Biosensors, School of Materials Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
  • Received:2019-07-12 Published:2019-09-18
  • Supported by:
    Project supported by the National Key Research and Development Program of China (No. 2017YFA0205302), the National Natural Science Foundation of China (Nos. 61671250, 21475064) and the Jiangsu College Students' innovation and entrepreneurship training program (No. SZD2018013).

DNA-二维纳米片层材料传感平台结合DNA分子特异性识别能力与二维纳米片层材料优越的物理、化学特性,已成为化学/生物传感器领域重要的研究方向之一.鉴于二维纳米片层材料领域的快速发展,首先介绍了DNA-二维纳米片层材料传感平台的构筑机理,随后重点综述了该传感平台在化学、生物目标物分析检测中的应用研究,并对该类传感平台的应用前景做了展望.

关键词: 二维纳米片层材料, DNA, 传感平台, 分析检测

Combining the specific recognition ability of DNA molecules with the superior physical and chemical properties of two-dimensional (2D) layered materials, a DNA-2D layered nanomaterial sensing platform was constructed. More and more researchers are devoted to develop this sensing platform, which has become one of the important research directions in the field of chemical/biological sensors. In view of the rapid development of the 2D layered materials, this paper firstly introduces the construction principle of the DNA-2D layered material sensing platform. Then we mainly review the application of the sensing platform in the analysis of chemical and biological molecules, including metal ions, mycotoxins, ATP, amino acid, antibiotics, nucleic acids, proteins and cancer cells. Finally, the future of this sensing platform is prospected.

Key words: two-dimensional layered nanomaterial, DNA, sensing platform, analysis