化学学报 ›› 2020, Vol. 78 ›› Issue (5): 373-381.DOI: 10.6023/A20020045 上一篇    下一篇

研究展望

近红外二区活体成像技术及其应用研究进展

罗兴蕊a,b, 陈敏文c, 杨晴来a,b,c   

  1. a 南华大学 肿瘤研究所 药物药理研究所 衡阳 421001;
    b 上海交通大学医学院附属仁济医院 分子医学研究院 上海 200127;
    c 深圳清华大学研究院 深圳 518057
  • 投稿日期:2020-02-26 发布日期:2020-04-10
  • 通讯作者: 陈敏文, 杨晴来 E-mail:ncuedu@126.com;qingyu513@126.com
  • 作者简介:罗兴蕊,本科毕业于南华大学,现为南华大学与上海交通大学医学院附属仁济医院联合培养在读研究生,目前的研究方向为有机合成,具体从事含氟有机化合物的合成及活性测定,有机荧光探针的合成及生物成像研究;陈敏文,硕士毕业于南昌大学,现为深圳清华大学研究院等离子体纳米生物芯片研发中心科研项目主管,目前主要从事肿瘤生物标志物筛选和生物成像检测研究;杨晴来,现为上海交通大学附属仁济医院副研究员,硕士生导师.博士毕业于上海交通大学,随后进入深圳清华大学研究院从事博士后研究.长期从事近红外二区有机分子探针,核酸适配体-核素偶联物PET分子探针及生物成像研究.
  • 基金资助:
    项目受国家自然科学基金(No.81801749)和深圳市基础研究项目(Nos.JCYJ20170307151634428,JCYJ20170817152825894)资助.

Research Progress on Near Infrared II Technology for in Vivo Imaging

Luo Xingruia,b, Chen Minwenc, Yang Qinglaia,b,c   

  1. a Cancer Research Institute of Medical College, and Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001;
    b Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127;
    c Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057
  • Received:2020-02-26 Published:2020-04-10
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 81801749) and Shenzhen Basic Research Funding (Nos. JCYJ20170307151634428, JCYJ20170817152825894).

近红外二区(NIR Ⅱ,1000~1700 nm)生物成像作为近年来新生的光学成像技术,相对于传统的近红外一区(NIR I,750~900 nm)和可见光(Vis,400~750 nm)成像,由于其荧光波长更长,生物组织的自发荧光背景更低,光子散射值更低,其组织穿透深度更深,该技术更适合于活体原位成像.本文综述了近红外二区荧光成像技术的发展及其在活体成像方面的应用,总结了各项技术的特点,最后对该研究方向的发展前景进行了展望,指出通过化学材料、光电仪器和多模态技术等多方面的持续发展,有望推动近红外二区活体成像技术的临床转化.

关键词: 近红外二区, 荧光探针, 活体成像, 临床转化

Near infrared II (NIR Ⅱ, 1000~1700 nm) biological imaging, as a new developing optical imaging technology in recent years, has longer fluorescence wavelength compared with the traditional near infrared I (NIR I, 750~900 nm) and visible light (Vis, 400~750 nm) imaging. Due to the longer emission wavelength, weaker interference by light scattering and tissue autofluorescence, result in higher temporal and spatial resolution with deeper tissue penetration. This technology is more suitable for in vivo imaging in situ. In this review, we mainly introduced research progress on NIR II instrument technology for in vivo imaging, and summarized its major features. Finally, we provided a prospect that the development of chemical materials, optoelectronic instruments, and multi-modal technologies can promote NIR II technology innovation, which is expected to be widely and deeply applied in clinical transformation.

Key words: near infrared II, fluorescent probe, in vivo imaging, clinical transformation