化学学报 ›› 1956, Vol. 22 ›› Issue (5): 379-385. 上一篇    下一篇

论文

二氮六圜衍生物Ⅰ.1-甲基-二氮六圜-4-二硫代甲酸烃酯柠檬酸盐及1-甲基-4-芳基氨基硫代甲醯二氮六圜柠檬酸盐的合成

文广伶, 董永明, 宋鸿锵, 张其楷   

  1. 医学科学院
  • 收稿日期:1956-06-25 出版日期:1956-10-15 发布日期:2013-06-04

PIPERAZINES Ⅰ.SYNTHESES OF ALKYL 1-METHYL-PIPERAZINE-4-DITHIOCARBAMATE CITRATES AND 1-METHYL-4-ARYL-THIOCARBAMYL-PIPERAZINE CITRATES

WEN KUANG-LING, TUNG YEONG-MING, SOONG HONG-TSIANG, CHANG CHI-CHIEK   

  1. Institute of Medical Science
  • Received:1956-06-25 Online:1956-10-15 Published:2013-06-04

本文制取两类二氮六圜衍生物,1-甲基-二氮六圜-4-二硫代申酸烃酯柠檬酸盐及1-甲基-4-芳基氨基硫代甲醯二氮六圜柠檬酸盐。1-甲基-二氮六圜-4-二硫代甲酸烃酯可由1-甲基-二氮六圜与二硫化碳及乙醇钠作用成1-甲基-二氮六圜-4-二硫代甲酸钠,而后分别与相当的鹵化烃作用制成。1-甲基-4-芳基氨基硫代甲醯二氮六圜可由1-甲基-二氮六圜及相当的异硫氰酸芳基酯在乙醚中作用制成。

Two series of piperazines,alkyl 1-methyl-piperazine-4-dithiocarbamate citrates and 1-methyl-4-aryl-thiocarbamyl-piperazine citrates have been- prepared for testing their therapeutic effect in the treatment of Schistosomiasis Japonica.The starting material used for these two series was 1-methyl-piperazine,prepared from piperazine by means of partial reductive methylation.By the interaction of I-methyl-piperazine with sodium ethoxide and carbon disulfide,we obtained sodium 1-methyl-piperazine-4-dithiocarbamate.This sodium salt reacted with alkyl halides to form alkyl I-methyl-piperazine-4-dithiocarbamates.1-Methyl-4-aryl-thiocarbamyl-piperazines were prepared from 1-methyl-piperazine and the ap-propriateenyl isothiocyanates in ether solution.