化学学报 ›› 1994, Vol. 52 ›› Issue (6): 588-594. 上一篇    下一篇

研究论文

新的环糊精手性固定相-七(2, 6-二-O-正丁基-3-O-三氟乙酰基)-β-环糊精

刘学良;郭方遒;楼献文;周良模   

  1. 中国科学院大连化学物理研究所
  • 出版日期:1994-06-15 发布日期:1994-06-15

A new chiral stationary phase-heptakis(2, 6-di-O-n-butyl-3-O- trifluoroacetyl)-β-cyclodextrin

LIU XUELIANG;GUO FANGQIU;LOU XIANWEN;ZHOU LIANGMO   

  • Online:1994-06-15 Published:1994-06-15

合成了一种新的手性固定相: 七(2, 6-二-O-正丁基-3-O-三氟乙酰基)-β-环糊精(DB-TFA-β-CD), 使用该固定相涂渍的石英毛细管柱, 对卤代烃、环氧化合物、酮、胺、醇、二醇、羧酸和氨基酸等化合物的对映体进行了色谱分离。结果表明:该固定相具有较好的对映体分离选择性。

关键词: 气相色谱, 固定相, 环糊精, 石英, 手征性, 毛细管柱, 对映体分离, β-环糊精, 三氟乙酰 P

A new chiral stationary phase, heptakis(2,6-di-O-n-butyl-3-O-trifluoroacetyl)-b-cyclodextrin (DB-TFA-b-CD), has been prepared from native b-cyclodextrin, and coated on fused silica capillary column. The sepns. of optical isomers including halohydrocarbon, epoxy compounds, ketones, alcs., diols, amines, carboxylic acids, and amino acids have been achieved. The results showed that the acyl groups of alcohol derivatives played a significant role in their enantioselective sepns. The choice of an acylation reagent can mean the difference between success and failure in obtaining an enantiomeric separation of alcohol Iso-leucine, allo-isoleucine, and proline which were seriously overlapped or poorly separated by amide CSPs were base-lined resolved on this CSP.

Key words: GAS CHROMATOGRAPHY, STATIONARY PHASE, CYCLODEXTRIN, QUARTZ, CHIRALITY, OPEN TUBULAR COLUMN

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