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化学学报
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化学学报 ›› 2000, Vol. 58 ›› Issue (7): 890-894. 上一篇    下一篇

研究论文

新的氨基酸受体的合成和分子识别性质研究

陆国元;万小宾;金传明;宋伟   

  1. 南京大学化学系.南京(210008)
  • 发布日期:2000-07-15

Synthesis and molecular recognition of novel receptor for amino acid zwitterions

Lu Guoyuan;Wan Xiaobin;Jin Chuanming;Song Wei   

  1. Nanjing Univ, Dept Chem.Nanjing(210008)
  • Published:2000-07-15

PDF

354

被引次数

27 | 6

从双氨基甲基手性双环胍出发，经三步反应合成了由稳定的共价键桥联双环胍、氮杂冠醚和萘环的氨基酸受体1.液-液竞争萃取和^1HNMR实验表明受体对氨基酸两性离子具有较好的侧链选择性和对映选择性，能够选择性地将L-芳香族氨基酸从水相转移到二氯甲烷有机相。

关键词: 氨基酸, 分子识别, 萃取, 冠醚, 质子磁共振谱法

A novel artificial receptor 1 for aromatic amino acid zwitterions was prepared in three steps from the chiral bis(aminomethyl) bicyclic guanidinium salt. The bicyclic guanidinium group is covalently connected with an azacrown ether and three naphthylmethyl group by means of chemically stable amide and imino bonds. The experiments of the competition extraction and ^1H NMR indicated that the receptor selectively binds to L-aromatic amino acid zwitterions and can transfer it from water into dichloromethane.

Key words: AMINO ACID, OLECULAR RECOGNITION, EXTRACTION, CROWN ETHER, PROTON MAGNETIC RESONANCE SPECTROMETRY

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