登革热病毒检测的生物传感技术

doi:10.6023/A21080410

化学学报 ›› 2022, Vol. 80 ›› Issue (1): 69-79.DOI: 10.6023/A21080410 上一篇下一篇

研究评论

登革热病毒检测的生物传感技术

师瑶^a^,^b, 夏乾峰^a, 何政清^a^,^b, 鞠熀先^b^,^*()

^a海南医学院热带医学与检验医学学院热带转化医学教育部重点实验室海口 571199
^b南京大学化学化工学院生命分析化学国家重点实验室南京 210023

投稿日期:2021-08-29 发布日期:2021-10-22
通讯作者: 鞠熀先

作者简介:

师瑶, 2020年本科毕业于海南医学院热带医学与检验医学院, 2020~2023年为海南医学院热带医学与检验医学院硕士研究生, 主要从事热带病检测方法的研究.

夏乾峰, 临床检验诊断学博士, 教授, 博士生导师. 现任海南医学院热带医学与检验医学院常务副院长(主持工作), 中华医学会热带病与寄生虫学专业委员会秘书长、海南省医学会热带病与寄生虫专业委员会主委、中国医检整合联盟常务理事、中国空间微生物学会委员、海南省微生物学会副理事长等. 研究方向为临床检验新方法和热带病防控关键技术. 主持传染病国家重大科技专项、海南省重大科技专项课题各1项、国家自然科学基金3项. 以第一或通讯作者发表论文50余篇(SCI收录28篇), 获海南省科技进步二等奖1项, 四川省科技进步二等奖1项, 海南省教学成果二等奖3项, 研发的新冠抗体检测试剂盒获欧盟CE认证, 并出口欧洲.

何政清, 2016年本科毕业于赣南医学院临床医学院, 2017~2020年为海南医学院基础医学院硕士研究生, 主要从事病原微生物核酸检测的研究.

鞠熀先, 1986、1989和1992年分别获南京大学理学学士、硕士和博士学位, 后留校任教, 1993年为副教授, 1999年聘为教授、博士生导师. 2003年获国家杰出青年科学基金, 2007年遴选为“长江学者”特聘教授, 2005~2014年主持国家自然科学基金创新研究群体项目、2009~2014年主持“973”计划项目. 现为生命分析国家重点实验室主任、国际电化学会会士、英国皇家化学会会士. 研究方向为分子诊断与生物分析化学, 主要研究领域为免疫分析、细胞分析化学、纳米生物传感和临床分子诊断, 至2021年10月, 发表论文772篇; 英文专著6部, 中文专著、教材7部, 专章20篇; SCI刊物他引35000多次, h-index为99 (Google Scholar h-index为107, 引用42000多次).

基金资助:
项目受国家自然科学基金(21635005); 项目受国家自然科学基金(21827812); 项目受国家自然科学基金(21890741)

Biosensing Technology for Dengue Virus Detection

Yao Shi^a^,^b, Qianfeng Xia^a, Zhengqing He^a^,^b, Huangxian Ju^b()

^aKey Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou 571199, China
^bState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Received:2021-08-29 Published:2021-10-22
Contact: Huangxian Ju
Supported by:
National Natural Science Foundation of China(21635005); National Natural Science Foundation of China(21827812); National Natural Science Foundation of China(21890741)

文章分享

摘要/Abstract

登革热病毒是由伊蚊传播的单链RNA病毒, 属于黄病毒科. 目前暂无靶向抗病毒药物及有效疫苗能够及时防控. 由于其临床检测的重要性, 近年来, 陆续出现了检测登革热病毒感染的新方法, 试图早期发现并控制这种感染. 本综述主要阐述登革热病毒诊断相关标志物检测的生物传感技术, 包括光学、电化学、酶联免疫吸附试验等生物传感方法, 对不同检测方法的灵敏度、准确性、检测范围、检测限和临床应用能力进行综合评价, 以利于进一步提高这些技术的检测性能, 促进该领域的发展, 并为登革热病毒感染的早期诊断提供参考.

关键词: 登革热病毒, 早期感染, 生物传感器, 检测技术, 早期诊断, 核酸检测

Dengue virus is a single-stranded RNA virus transmitted by mosquitoes, belonging to the flaviviridae. Currently, there are no targeted antiviral drugs and effective virus vaccines of timely prevention. Due to the importance of clinical detection, new methods for detecting Dengue virus infection have emerged in recent years, trying to detect and control this infection early. This review mainly describes the biosensing technologies for the detection of Dengue virus related diagnostic markers, including optical, electrochemical, enzyme-linked immunosorbent assay and other biosensing methods, and comprehensively evaluates the sensitivity, accuracy, concentration range, detection limit and clinical application ability of different detection methods, so as to further improve the detection performance of these technologies, and to promote the development of this field. It will provide references for the early diagnosis of Dengue virus infection.

Key words: Dengue virus, early infection, biosensor, detection technology, early diagnosis, nucleic acid test

引用此文

师瑶, 夏乾峰, 何政清, 鞠熀先. 登革热病毒检测的生物传感技术[J]. 化学学报, 2022, 80(1): 69-79.

Yao Shi, Qianfeng Xia, Zhengqing He, Huangxian Ju. Biosensing Technology for Dengue Virus Detection[J]. Acta Chimica Sinica, 2022, 80(1): 69-79.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

分享此文

图/表 12

图1. MMS-夹心ELISA方法检测登革热抗原(Ag)的原理图[32]

Figure 1. Scheme for MMS-sandwich ELISA of Dengue antigen (Ag)[32]

图2. 基于ELISA的聚羟基丁酸酯(PHB)纤维检测登革热病毒[33]. (a)静电纺丝法制备PHB纤维, (b) PHB纤维浸涂, (c)和(d) PHB和聚合物poly(MMA-co-MAA)结构式, (e) 登革热抗体的物理附着, (f) 用EDC/NHS共价固定登革热抗体, EDC: 1-乙基-(3-二甲基氨基丙基)碳酰二亚胺, NHS: N-羟基琥珀酰亚胺磺酸钠盐

Figure 2. Scheme of PHB fibers-based ELISA for Dengue virus detection[33]. (a) Electrospinning technique for fabrication of PHB fibers, (b) dip-coating by immersing PHB fibers, (c) and (d) chemical structures of PHB and poly(MMA-co-MAA), (e) physical attachment of Dengue Ab to the coated surface, (f) covalent immobilization of Dengue Ab by EDC/NHS treatment, EDC: 1-(3-dimethylaminopropyl)-3-ethylcarbo- diimide hydrochloride, NHS: N-hydroxysulfosuccinimide sodium salt

图3. 涂布纸与抗IgM抗体结合的方法[36]

Figure 3. Method of binding coated paper and IgM antibody[36]

Detection method	Type of Dengue	Nano materials	Limit of detection	Linear range	Reference
Optical DNA biosensor	Dengue serotype 2	Silica nanospheres	0.2 amol/L	1.0×10^-16~1.0×10^-10 mol/L	^[17]
SERS based lateral flow biosensor	NS1 protein	—	15 ng/mL	15~500 ng/mL	^[18]
Label-free biosensor	Dengue serotype 2	—	1 pmol/L	—	^[58]
Colorimetric biosensor	Different Dengue serotypes	Silver nanoparticles	—	—	^[59]
SPR biosensor	—	AuNPs	—	31~260 copies/mL	^[60]
Optical DNA biosensor	Dengue serotype 2	Silica nanoparticles	1 zmol/L	1.0×10^-15~1.0×10^-11mol/L	^[61]
SRP biosensor	Dengue serotype 2 and 3	—	2×10⁴ particles/mL	—	^[62]
LSPR fiber optic sensor	Dengue anti-NS1 antibody	Gold nanoparticles	1.54 nmol/L	—	^[7]
LSPR biosensor	Dengue anti-NS1 antibody	—	5.73 pg/mm²	—	^[63]
SRP biosensor	Dengue serotype 2	rGO-PAMAM	—	0.08~0.5 pmol/L	^[64]
Optical DNA biosensor	Dengue DNA sequence	AuNPs	1×10^-29 mol/L	1.0×10^-21~1.0×10^-12 mol/L	^[65]
Optical DNA biosensor	Dengue DNA sequence	—	2 fmol/L	≈1 pmol/L	^[66]
SERS biosensor	NS1 protein	Silver nanorods	—	—	^[67]
SERS biosensor	NS1 protein	AuNPs	7.67 ng/mL	—	^[68]
SERS biosensor	Dengue DNA sequence	—	0.49 fmol/L	1 fmol/L~10 nmol/L	^[69]
SRP biosensor	Dengue serotype 2	—	0.08 pmol/L	0.08~5 pmol/L	^[70]

表1. 检测登革热病毒的光学生物传感器

Table 1. Optical biosensors for detection of Dengue virus

图4. 级联催化发夹自组装(LCHA)和杂交链反应(HCR)无酶扩增策略用于登革热病毒SERS检测示意图[69]

Figure 4. Illustration of SERS assay of DENV gene via a cascade enzyme-free signal amplification strategy of localized catalytic hairpin assembly (LCHA) and hybridization chain reaction (HCR)[69]

图5. 靶催化芘标记发夹自组装用于指数放大的生物传感器[93]

Figure 5. Target-catalyzed assembly of pyrene-labeled hairpins for exponentially amplified biosensing[93]

Electrode	Detection technique	Analyte	Linear range	Limit of detection	Reference
CNT-SPE	CA	NS1	0.04~2 μg/mL	12 ng/mL	^[94]
PAH/CNT	CV	NS1	0.1~2.5 μg/mL	0.035 μg/mL	^[95]
Au/CD	DPV	NS1	1~100 ng/mL	0.33 ng /mL	^[96]
Nanoporous alumina/Pt wire	DPV	DENV-2	1~10³ pfu/mL	1 pfu/mL	^[97]
PGE	DPV	DENV-1	1~40 nmol/L	0.92 nmol/L	^[98]
Nanoporous alumina/Pt wire	DPV	DENV1(31-mer ssDNA)	10^-12~10^-6mol/L	9.55×10^-12mol/L	^[99]
ZnO/Pt-Pd	CV/DPV	DENV target ssDNA	1×10^-6~100×10^-6mol/L	4.3×10^-6mol/L	^[100]
Mn₂O₃nanofiber	CV/DPV/EIS	Dengue consensus primer	1 nmol/L~1 μmol/L	120×10^-21mol/L	^[101]
Thiophene-SPE/AuNPs /Protein A	CV/EIS	NS1	0.04~0.6 μg/mL	0.015 μg/mL	^[102]
PGE	DPV	DENV-3	10~100 nmol/L	3.09 nmol/L	^[87]
Au	EIS/CV	NS1	0.1~10 μg/mL	0.09 μg/mL	^[103]
Au	EIS/CV	NS1	0.01~1.00 μg/mL	30 ng/mL	^[104]
Au/liposome	EIS/CV	DENV-1~DENV-3	0.01~1.00 μg/mL	3 ng/mL	^[105]
AuNPs/PVB	EIS/CV	Dengue fever and Dengue haemorrhagic	—	—	^[106]
Fe₃O₄/PVB	EIS/CV	DENV-1~DENV-3	—	—	^[107]
AuNPs/PANI/CramoLL	EIS/CV	Glycoproteins from DENV-1~DENV-3	—	—	^[108]
AuNPs/PANI/BMOLL	EIS/CV	Glycoproteins from DENV-1~DENV-3	—	—	^[109]
CNT/polypyrrole-NHS	EIS/CV	DENV-2	10^-13~10^-5g/mL	—	^[110]
Cys-MBA-AuNPs	EIS/CV	DENV-1~DENV-4	—	—	^[111]
GO-PMC	EIS/CV	DENV-1~DENV-4	1~2×10³pfu/mL	0.12 pfu/mL	^[112]
AAO	EIS/CV	DENV DNA	1×10^-12~1×10^-6mol/L	2.7×10^-12mol/L	^[113]
SiO₂/APTES-GO	EIS	DENV DNA	—	1 fmol/L	^[114]

表2. 电化学登革热病毒生物传感器的最新发展

Table 2. Recent developments in electrochemical Dengue virus biosensors

图6. 树枝状HCR电化学检测DENV核酸的示意图[131]

Figure 6. Schematic illustration of dendritic HCR for electrochemical detection of DENV nucleic acid[131]

图7. 用丝网印刷金电极研制的登革热NS1蛋白电化学侧流传感器. (A)第1代7 cm长的夹心免疫传感器[118], (B)第2代4 cm长化学修饰聚乙二醇稳定和四甲基哌啶标记的AuNPs夹心免疫传感器[132]

Figure 7. Schematic representation of screen-printed gold electrodes based electrochemical lateral flow immunosensor for detection of Dengue NS1 protein. (A) 1st generation with 7 cm length and immunonanobeads (AuNPs-AB-Fc)[118], (B) 2nd generation with 4 cm length and chemically modified PEG-stabilized and TEMPO-tagged AuNPs[132]

图8. DENV-2型电化学免疫传感器的制备与检测过程示意图[134]

Figure 8. Schematic representation for the formation of electrochemical immunosensor and its operation to detect DENV-2[134]

图9. 氧化石墨烯/聚合物材料基的DENV阻抗传感器制备与检测[112]

Figure 9. Fabrication of graphene oxide/polymer matrix composite- based biosensor for detection of Dengue virus[112]

图10. 功能化单壁纳米管网络构建的非结构蛋白1 (NS1)无标记免疫传感器示意图[139]

Figure 10. Schematic of label-free immunosensors for non-structural protein 1 (NS1) by functionalizing single-walled nanotubes networks[139]

参考文献 140

[1]	Castro, M. C.; Wilson, M. E.; Bloom, D. E. Lancet Infect. Dis. 2017, 17, e70. doi: 10.1016/S1473-3099(16)30545-X
[2]	Chong, H. Y.; Leow, C. Y.; Abdul Majeed, A. B.; Leow, C. H. Virus Res. 2019, 274, a197770.
[3]	Khristunova, E.; Dorozhko, E.; Korotkova, E.; Kratochvil, B.; Vyskocil, V.; Barek, J. Sensors 2020, 20, 4600. doi: 10.3390/s20164600
[4]	Guzman, M. G.; Gubler, D. J.; Izquierdo, A.; Martinez, E.; Halstead, S. B. Nat. Rev. Dis. Primers 2016, 2, 16055. doi: 10.1038/nrdp.2016.55
[5]	Castillo Signor, L. D. C.; Edwards, T.; Escobar, L. E.; Mencos, Y.; Matope, A.; Castaneda Guzman, M.; Adams, E. R.; Cuevas, L. E. PLoS Negl. Trop. Dis. 2020, 14, e0008535. doi: 10.1371/journal.pntd.0008535
[6]	Li, G. H.; Ning, Z. J.; Liu, Y. M.; Li, X. H. Front. Cell. Infect. Mi. 2017, 7, 449.
[7]	Bhatt, S.; Gething, P. W.; Brady, O. J.; Messina, J. P.; Farlow, A. W.; Moyes, C. L.; Drake, J. M.; Brownstein, J. S.; Hoen, A. G.; Sankoh, O.; Myers, M. F.; George, D. B.; Jaenisch, T.; Wint, G. R.; Simmons, C. P.; Scott, T. W.; Farrar, J. J.; Hay, S. I. Nature 2013, 496, 504. doi: 10.1038/nature12060
[8]	Brady, O. J.; Gething, P. W.; Bhatt, S.; Messina, J. P.; Brownstein, J. S.; Hoen, A. G.; Moyes, C. L.; Farlow, A. W.; Scott, T. W.; Hay, S. I. PLoS Negl. Trop. Dis. 2012, 6, e1760. doi: 10.1371/journal.pntd.0001760
[9]	Banu, S.; Hu, W.; Guo, Y.; Naish, S.; Tong, S. PLoS One 2014, 9, e89440. doi: 10.1371/journal.pone.0089440
[10]	Supadmi, W.; Suwantika, A. A.; Perwitasari, D. A.; Abdulah, R. Value Health 2019, 18, 132.
[11]	Shepard, D. S.; Undurraga, E. A.; Halasa, Y. A.; Stanaway, J. D. Lancet Infect. Dis. 2016, 16, 935. doi: 10.1016/S1473-3099(16)00146-8
[12]	Cassedy, A.; Parle McDermott, A.; O'Kennedy, R. Front. Mol. Biosci. 2021, 8, 637559. doi: 10.3389/fmolb.2021.637559
[13]	Kim, J. H.; Cho, C. H.; Ryu, M. Y.; Kim, J. G.; Lee, S. J.; Park, T. J.; Park, J. P. PLoS One 2019, 14, e0222144. doi: 10.1371/journal.pone.0222144
[14]	Yang, Y. H.; Song, Z. Y.; Zheng, X. L. J. Pathogen Biol. 2017, 12, 803 ; (in Chinese)
	( 杨永红, 宋璋瑶, 郑学礼, 中国病原生物学杂志, 2017, 12, 803.)
[15]	Jiang, L. Y.; Di, B.; Yang, Z. C. J. Mol. Diagn. Ther. 2018, 3, 196.; (in Chinese)
	( 蒋力云, 狄飚, 杨智聪, 分子诊断与治疗杂志, 2018, 3, 196.)
[16]	Rodriguez, R. A.; Pepper, I. L.; Gerba, C. P. Appl. Environ. Microb. 2009, 75, 297. doi: 10.1128/AEM.01150-08
[17]	Ariffin, E. Y.; Tan, L. L.; Abd Karim, N. H.; Heng, L. Y. Sensors 2018, 18, 1173. doi: 10.3390/s18041173
[18]	Darwish, N. T.; Sekaran, S. D.; Alias, Y.; Khor, S. M. J. Pharmaceut. Biomed. 2018, 149, 591. doi: 10.1016/j.jpba.2017.11.064
[19]	Anusha, J. R.; Kim, B. C.; Yu, K. H.; Raj, C. J. Biosens. Bioelectron. 2019, 142, 111511. doi: 10.1016/j.bios.2019.111511
[20]	Kwakye, S.; Goral, V. N.; Baeumner, A. J. Biosens. Bioelectron. 2006, 21, 2217. doi: 10.1016/j.bios.2005.11.017
[21]	Jain, J.; Okabayashi, T.; Kaur, N.; Nakayama, E.; Shioda, T.; Gaind, R.; Kurosu, T.; Sunil, S. J. Virol. 2018, 15, 84. doi: 10.1186/s12985-018-1000-0
[22]	Teles, F. S. Anal. Chim. Acta 2011, 687, 28. doi: 10.1016/j.aca.2010.12.011
[23]	Guzman, M. G.; Kouri, G. Int. J. Infect. Dis. 2004, 8, 69. doi: 10.1016/j.ijid.2003.03.003
[24]	Raafat, N.; Loganathan, S.; Mukaka, M.; Blacksell, S. D.; Maude, R. J. PLoS Negl. Trop. Dis. 2021, 15, e0009359. doi: 10.1371/journal.pntd.0009359
[25]	Wang, J.; Ma, P.; Kim, D. H.; Liu, B. F.; Demirci, U. Nano Today 2021, 37, 101066. doi: 10.1016/j.nantod.2020.101066
[26]	Sekaran, S. D.; Soe, H. J. Expert Rev. Mol. Diagn. 2017, 17, 217. doi: 10.1080/14737159.2017.1275963
[27]	Pashazadeh, P.; Mokhtarzadeh, A.; Hasanzadeh, M.; Hejazi, M.; Hashemi, M.; De La Guardia, M. Biosens. Bioelectron. 2017, 87, 1050. doi: 10.1016/j.bios.2016.08.012
[28]	Asokanathan, C.; Tierney, S.; Ball, C. R.; Buckle, G.; Day, A.; Tanley, S.; Bristow, A.; Markey, K.; Xing, D.; Yuen, C. T. Anal. Biochem. 2018, 540, 15.
[29]	Alamdari, D. H.; Kostidou, E.; Paletas, K.; Sarigianni, M.; Konstas, A. G.; Karapiperidou, A.; Koliakos, G. Free Radical Bio. Med. 2005, 39, 1362. doi: 10.1016/j.freeradbiomed.2005.06.023
[30]	Kim, A.; Li, C. R.; Jin, C. F.; Lee, K. W.; Lee, S. H.; Shon, K. J.; Park, N. G.; Kim, D. K.; Kang, S. W.; Shim, Y. B.; Park, J. S. Chemosphere 2007, 68, 1204. doi: 10.1016/j.chemosphere.2007.01.079
[31]	Thiha, A.; Ibrahim, F. Sensors 2015, 15, 11431. doi: 10.3390/s150511431
[32]	Hosseini, S.; Ibrahim, F.; Djordjevic, I.; Rothan, H. A.; Yusof, R.; Van Der Marel, C.; Benzina, A.; Koole, L. H. Eur. Polym. J. 2014, 60, 14. doi: 10.1016/j.eurpolymj.2014.08.010
[33]	Hosseini, S.; Azari, P.; Farahmand, E.; Gan, S. N.; Rothan, H. A.; Yusof, R.; Koole, L. H.; Djordjevic, I.; Ibrahim, F. Biosens. Bioelectron. 2015, 69, 257. doi: 10.1016/j.bios.2015.02.034
[34]	Farahmand, E.; Ibrahim, F.; Hosseini, S.; Rothan, H. A.; Yusof, R.; Koole, L. H.; Djordjevic, I. Appl. Surf. Sci. 2015, 353, 1310. doi: 10.1016/j.apsusc.2015.07.004
[35]	Hosseini, S.; Azari, P.; Aeinehvand, M. M.; Rothan, H. A.; Djordjevic, I.; Martinez Chapa, S. O.; Madou, M. J. Appl. Sci. 2016, 6, 336. doi: 10.3390/app6110336
[36]	Ortega, G. A.; Pérez-Rodríguez, S.; Reguera, E. RSC Adv. 2017, 7, 4921. doi: 10.1039/C6RA25992H
[37]	Bang, J.; Park, H.; Choi, W. I.; Sung, D.; Lee, J. H.; Lee, K. Y.; Kim, S. New J. Chem. 2018, 42, 12607. doi: 10.1039/C8NJ02244E
[38]	Chong, Z. L.; Sekaran, S. D.; Soe, H. J.; Peramalah, D.; Rampal, S.; Ng, C. W. BMC Infect. Dis. 2020, 20, 210. doi: 10.1186/s12879-020-4911-5
[39]	Mairiang, D.; Songjaeng, A.; Hansuealueang, P.; Malila, Y.; Lertsethtakarn, P.; Palomares Reyes, C.; Silva Caso, W.; Del Valle, L. J.; Aguilar Luis, M. A.; Weilg, C.; Martins-Luna, J.; Vinas Ospino, A.; Stimmler, L.; Mallqui Espinoza, N.; Aquino Ortega, R.; Espinoza Espiritu, W.; Misaico, E.; Del Valle Mendoza, J. Int. J. Infect. Dis. 2019, 81, 31. doi: 10.1016/j.ijid.2019.01.022
[40]	Palomares Reyes, C.; Silva Caso, W.; Del Valle, L. J.; Aguilar Luis, M. A.; Weilg, C.; Martins Luna, J.; Vinas Ospino, A.; Stimmler, L.; Mallqui Espinoza, N.; Aquino Ortega, R.; Espinoza Espiritu, W.; Misaico, E.; Del Valle-Mendoza, J. Int. J. Infect. Dis. 2019, 81, 31. doi: 10.1016/j.ijid.2019.01.022
[41]	Xu, Y.; Wang, T.; Chen, Z.; Jin, L.; Wu, Z.; Yan, J.; Zhao, X.; Cai, L.; Deng, Y.; Li, S.; He, N. Chin. Chem. Lett. 2021, 17, 9.
[42]	Xiong, Y.; Luo, Y.; Li, H.; Wu, W.; Ruan, X.; Mu, X. Int. J. Infect. Dis. 2020, 95, 406. doi: 10.1016/j.ijid.2020.03.075
[43]	Singh, R. K.; Dhama, K.; Karthik, K.; Tiwari, R.; Khandia, R.; Munjal, A.; Iqbal, H. M. N.; Malik, Y. S.; Bueno Mari, R. Front. Microbiol. 2017, 8, 2677. doi: 10.3389/fmicb.2017.02677
[44]	Sasmono, R. T.; Santoso, M. S.; Pamai, Y. W. B.; Yohan, B.; Afida, A. M.; Denis, D.; Hutagalung, I. A.; Johar, E.; Hayati, R. F.; Yudhaputri, F. A.; Haryanto, S.; Stubbs, S. C. B.; Blacklaws, B. A.; Myint, K. S. A.; Frost, S. D. W. Front. Med. 2020, 7, 582235. doi: 10.3389/fmed.2020.582235
[45]	Walper, S. A.; Lasarte Aragones, G.; Sapsford, K. E.; Brown, C. W.,3rd; Rowland, C. E.; Breger, J. C.; Medintz, I. L.; ACS Sensors 2018, 3, 1894. doi: 10.1021/acssensors.8b00420
[46]	Goud, K. Y.; Reddy, K. K.; Khorshed, A.; Kumar, V. S.; Mishra, R. K.; Oraby, M.; Ibrahim, A. H.; Kim, H.; Gobi, K. V. Biosens. Bioelectron. 2021, 180, 113112. doi: 10.1016/j.bios.2021.113112
[47]	Sasmono, R. T.; Aryati, A.; Wardhani, P.; Yohan, B.; Trimarsanto, H.; Fahri, S.; Setianingsih, T. Y.; Meutiawati, F. PLoS One 2014, 9, e103815. doi: 10.1371/journal.pone.0103815
[48]	Lopez-Jimena, B.; Bekaert, M.; Bakheit, M.; Frischmann, S.; Patel, P.; Simon Loriere, E.; Lambrechts, L.; Duong, V.; Dussart, P.; Harold, G.; Fall, C.; Faye, O.; Sall, A. A.; Weidmann, M. PLoS Negl. Trop. Dis. 2018, 12, e0006381. doi: 10.1371/journal.pntd.0006381
[49]	Teoh, B. T.; Sam, S. S.; Tan, K. K.; Danlami, M. B.; Shu, M. H.; Johari, J.; Hooi, P. S.; Brooks, D.; Piepenburg, O.; Nentwich, O.; Wilder Smith, A.; Franco, L.; Tenorio, A.; Abubakar, S. J. Clin. Microbiol. 2015, 53, 830. doi: 10.1128/JCM.02648-14
[50]	Xi, Y.; Xu, C. Z.; Xie, Z. Z.; Zhu, D. L.; Dong, J. M. Mol. Cell. Probe. 2019, 46, 101413. doi: 10.1016/j.mcp.2019.06.003
[51]	Darwish, N. T.; Alrawi, A. H.; Sekaran, S. D.; Alias, Y.; Khor, S. M. J. Electrochem. Soc. 2016, 163, B19. doi: 10.1149/2.0471603jes
[52]	Gao, M.; Waggoner, J. J.; Hecht, S. M.; Chen, S. ACS Infect. Dis. 2019, 5, 1907. doi: 10.1021/acsinfecdis.9b00241
[53]	Romano, S.; Lamberti, A.; Masullo, M.; Penzo, E.; Cabrini, S.; Rendina, I.; Mocella, V. Materials 2018, 11, 526. doi: 10.3390/ma11040526
[54]	Kravtsov, V.; Khestanova, E.; Benimetskiy, F. A.; Ivanova, T.; Samusev, A. K.; Sinev, I. S.; Pidgayko, D.; Mozharov, A. M.; Mukhin, I. S.; Lozhkin, M. S.; Kapitonov, Y. V.; Brichkin, A. S.; Kulakovskii, V. D.; Shelykh, I. A.; Tartakovskii, A. I.; Walker, P. M.; Skolnick, M. S.; Krizhanovskii, D. N.; Iorsh, I. V. Light Sci. Appl. 2020, 9, 56. doi: 10.1038/s41377-020-0286-z
[55]	Eivazzadeh Keihan, R.; Pashazadeh Panahi, P.; Baradaran, B.; De La Guardia, M.; Hejazi, M.; Sohrabi, H.; Mokhtarzadeh, A.; Maleki, A. Trend. Anal. Chem. 2018, 103, 184. doi: 10.1016/j.trac.2018.03.019
[56]	Hao, N.; Pei, Z.; Liu, P.; Bachman, H.; Naquin, T. D.; Zhang, P.; Zhang, J.; Shen, L.; Yang, S.; Yang, K.; Zhao, S.; Huang, T. J. Small Methods 2020, 16, e2005179.
[57]	Zhou, H.; Liu, J.; Xu, J. J.; Zhang, S. S.; Chen, H. Y. Chem. Soc. Rev. 2018, 47, 1996. doi: 10.1039/C7CS00573C
[58]	Mustapha Kamil, Y.; Abu Bakar, M. H.; Mustapa, M. A.; Yaacob, M. H.; Abidin, N. H. Z.; Syahir, A.; Lee, H. J.; Mahdi, M. A. Sens. Actuators B Chem. 2018, 257, 820. doi: 10.1016/j.snb.2017.11.005
[59]	Vinayagam, S.; Rajaiah, P.; Mukherjee, A.; Natarajan, C. Spectrochim. Acta A 2018, 202, 346. doi: 10.1016/j.saa.2018.05.047
[60]	Adegoke, O.; Park, E. Y. J. Mater. Chem. B 2017, 5, 3047. doi: 10.1039/C7TB00388A
[61]	Mazlan, N. F.; Tan, L. L.; Karim, N. H. A.; Heng, L. Y.; Reza, M. I. H. Sens. Actuators B Chem. 2017, 242, 176. doi: 10.1016/j.snb.2016.11.032
[62]	Loureiro, F. C. C. L.; Neff, H.; Melcher, E. U. K.; Roque, R. A.; De Figueiredo, R. M. P.; Thirstrup, C.; Borre, M. B.; Lima, A. M. N. Sens. Bio-Sens. Res. 2017, 13, 96.
[63]	Wong, W. R.; Sekaran, S. D.; Mahamd Adikan, F. R.; Berini, P. Biosens. Bioelectron. 2016, 78, 132. doi: 10.1016/j.bios.2015.11.030
[64]	Omar, N. A. S.; Fen, Y. W.; Abdullah, J.; Sadrolhosseini, A. R.; Mustapha Kamil, Y.; Fauzi, N. M.; Hashim, H. S.; Mahdi, M. A. Nanomaterials 2020, 10, 569. doi: 10.3390/nano10030569
[65]	Jeningsih; Tan, L. L.; Ulianas, A.; Heng, L. Y.; Mazlan, N. F.; Jamaluddin, N. D.; Mohd Yusof, N. Y.; Khalid, B.; Ta, G. C.. Sensors 2020, 20, 1820. doi: 10.3390/s20071820
[66]	Tian, B.; Fock, J.; Minero, G. A. S.; Hansen, M. F. Biosens. Bioelectron. 2020, 160, 112219. doi: 10.1016/j.bios.2020.112219
[67]	Gahlaut, S. K.; Savargaonkar, D.; Sharan, C.; Yadav, S.; Mishra, P.; Singh, J. P. Anal. Chem. 2020, 92, 2527. doi: 10.1021/acs.analchem.9b04129
[68]	Sanchez-Purra, M.; Carre-Camps, M.; De Puig, H.; Bosch, I.; Gehrke, L.; Hamad-Schifferli, K. ACS Infect. Dis. 2017, 3, 767. doi: 10.1021/acsinfecdis.7b00110
[69]	Song, C.; Zhang, J.; Liu, Y.; Guo, X.; Guo, Y.; Jiang, X.; Wang, L. Sens. Actuators B Chem. 2020, 325, 128970. doi: 10.1016/j.snb.2020.128970
[70]	Omar, N. A. S.; Fen, Y. W.; Ramli, I.; Sadrolhosseini, A. R.; Abdullah, J.; Yusof, N. A.; Kamil, Y. M.; Mahdi, M. A. Polymers 2021, 13, 762. doi: 10.3390/polym13050762
[71]	Santos, A.; Bueno, P. R.; Davis, J. J. Biosens. Bioelectron. 2018, 100, 519. doi: 10.1016/j.bios.2017.09.014
[72]	Brazaca, L. C.; Dos Santos, P. L.; De Oliveira, P. R.; Rocha, D. P.; Stefano, J. S.; Kalinke, C.; Abarza Munoz, R. A.; Bonacin, J. A.; Janegitz, B. C.; Carrilho, E. Anal. Chim. Acta 2021, 1159, 338384. doi: 10.1016/j.aca.2021.338384
[73]	Huang, M. C. Y.; Mateus, C. F. R.; Foley, J. E.; Beatty, R.; Cunningham, B. T.; Chang-Hasnain, C. J. IEEE Photon. Technol. Lett. 2008, 20, 443. doi: 10.1109/LPT.2008.916947
[74]	Carrillo, C.; Werbajh, S.; Malnero, C.; Stolowicz, F.; Larocca, L.; Malirat, V.; Vojnov, A. Int. J. Infect. Dis. 2018, 73, 171.
[75]	Rahman, S. A.; Saadun, R.; Azmi, N. E.; Ariffin, N.; Abdullah, J.; Yusof, N. A.; Sidek, H.; Hajian, R. J. Nanomater. 2014, 2014, 839286.
[76]	Ferraz, F. O.; Quaresma Bomfim, M. R.; Totola, A. H.; Avila, T. V.; Cisalpino, D.; Marques Pessanha, J. E.; De Souza, D. d. G.; Teixeira Junior, A. L.; Nogueira, M. L.; Bruna Romero, O.; Teixeira, M. M. J. Clin. Virol. 2013, 58, 41. doi: 10.1016/j.jcv.2013.06.015
[77]	Pal, S.; Dauner, A. L.; Mitra, I.; Forshey, B. M.; Garcia, P.; Morrison, A. C.; Halsey, E. S.; Kochel, T. J.; Wu, S. J. PLoS One 2014, 9, e113411. doi: 10.1371/journal.pone.0113411
[78]	Sanchez Vargas, L. A.; Sanchez Marce, E. E.; Vivanco Cid, H. Diagn. Micr. Infect. Dis. 2014, 78, 368.
[79]	Fu, C.; Gu, Y.; Wu, Z.; Wang, Y.; Xu, S.; Xu, W. Sens. Actuators B Chem. 2014, 201, 173. doi: 10.1016/j.snb.2014.04.091
[80]	Dinish, U. S.; Balasundaram, G.; Chang, Y. T.; Olivo, M. Sci. Rep. 2015, 4, 4075. doi: 10.1038/srep04075
[81]	Xia, X.; Li, W.; Zhang, Y.; Xia, Y. Interface Focus 2013, 3, 20120092. doi: 10.1098/rsfs.2012.0092
[82]	Ngo, H. T.; Wang, H. N.; Fales, A. M.; Nicholson, B. P.; Woods, C. W.; Vo-Dinh, T. Analyst 2014, 139, 5655. doi: 10.1039/C4AN01077A
[83]	Mohammadzadeh Asl, S.; Keshtkar, A.; Ezzati Nazhad Dolatabadi, J.; De La Guardia, M. Biosens. Bioelectron. 2018, 110, 118. doi: 10.1016/j.bios.2018.03.051
[84]	Hage, D. S. Clin. Chem. 2018, 64, 991. doi: 10.1373/clinchem.2017.282699
[85]	Hu, D.; Fry, S. R.; Huang, J. X.; Ding, X.; Qiu, L.; Pan, Y.; Chen, Y.; Jin, J.; McElnea, C.; Buechler, J.; Che, X.; Cooper, M. A. Biosensors 2013, 3, 297.
[86]	Jahanshahi, P.; Sekaran, S. D.; Adikan, F. R. M. Med. Biol. Eng. Comput. 2015, 53, 679. doi: 10.1007/s11517-015-1262-2
[87]	Oliveira, N.; Souza, E.; Ferreira, D.; Zanforlin, D.; Bezerra, W.; Borba, M. A.; Arruda, M.; Lopes, K.; Nascimento, G.; Martins, D.; Cordeiro, M.; Lima-Filho, J. Sensors 2015, 15, 15562. doi: 10.3390/s150715562
[88]	Chan, S. K.; Choong, Y. S.; Perera, D.; Lim, T. S. Anal. Methods 2018, 10, 214. doi: 10.1039/C7AY02131C
[89]	Shen, W.; Gao, Z. Biosens. Bioelectron. 2015, 65, 327. doi: 10.1016/j.bios.2014.10.060
[90]	Chowdhury, A. D.; Ganganboina, A. B.; Nasrin, F.; Takemura, K.; Doong, R. a.; Utomo, D. I. S.; Lee, J.; Khoris, I. M.; Park, E. Y. Anal. Chem. 2018, 90, 12464. doi: 10.1021/acs.analchem.8b01802
[91]	Hsieh, M. S.; Chen, M. Y.; Hsieh, C. H.; Pan, C. H.; Yu, G. Y.; Chen, H. W. PLoS One 2017, 12, e0188170. doi: 10.1371/journal.pone.0188170
[92]	Xie, B. P.; Qiu, G. H.; Hu, P. P.; Liang, Z.; Liang, Y. M.; Sun, B.; Bai, L. P.; Jiang, Z. H.; Chen, J. X. Sens. Actuators B Chem. 2018, 254, 1133. doi: 10.1016/j.snb.2017.06.085
[93]	He, Z.; Wu, J.; Qiao, B.; Pei, H.; Xia, Q.; Wu, Q.; Ju, H. ACS Appl. Bio Mater. 2020, 3, 5342. doi: 10.1021/acsabm.0c00658
[94]	Dias, A. C. M. S.; Gomes Filho, S. L. R.; Silva, M. M. S.; Dutra, R. F. Biosens. Bioelectron. 2013, 44, 216. doi: 10.1016/j.bios.2012.12.033
[95]	Silva, M. M. S.; Dias, A. C. M. S.; Silva, B. V. M.; Gomes-Filho, S. L. R.; Kubota, L. T.; Goulart, M. O. F.; Dutra, R. F. J. Chem. Technol. Biot. 2015, 90, 194.
[96]	Cavalcanti, I. T.; Guedes, M. I. F.; Sotomayor, M. D. P. T.; Yamanaka, H.; Dutra, R. F. Biochem. Eng. J. 2012, 67, 225. doi: 10.1016/j.bej.2012.06.016
[97]	Cheng, M. S.; Ho, J. S.; Tan, C. H.; Wong, J. P.; Ng, L. C.; Toh, C. S. Anal. Chim. Acta 2012, 725, 74. doi: 10.1016/j.aca.2012.03.017
[98]	Souza, E.; Nascimento, G.; Santana, N.; Ferreira, D.; Lima, M.; Natividade, E.; Martins, D.; Lima-Filho, J. Sensors 2011, 11, 5616. doi: 10.3390/s110605616
[99]	Rai, V.; Hapuarachchi, H. C.; Ng, L. C.; Soh, S. H.; Leo, Y. S.; Toh, C. S. PLoS One 2012, 7, e42346. doi: 10.1371/journal.pone.0042346
[100]	Singhal, C.; Pundir, C. S.; Narang, J. Biosens. Bioelectron. 2017, 97, 75. doi: 10.1016/j.bios.2017.05.047
[101]	Tripathy, S.; Krishna Vanjari, S. R.; Singh, V.; Swaminathan, S.; Singh, S. G. Biosens. Bioelectron. 2017, 90, 378. doi: 10.1016/j.bios.2016.12.008
[102]	Silva, M. M.; Dias, A. C.; Cordeiro, M. T.; Marques, E.,Jr.; Goulart, M. O.; Dutra, R. F.; Talanta 2014, 128, 505. doi: 10.1016/j.talanta.2014.06.009
[103]	Figueiredo, A.; Vieira, N. C.; Dos Santos, J. F.; Janegitz, B. C.; Aoki, S. M.; Junior, P. P.; Lovato, R. L.; Nogueira, M. L.; Zucolotto, V.; Guimaraes, F. E. Sci. Rep. 2015, 5, 7865. doi: 10.1038/srep07865
[104]	Cecchetto, J.; Carvalho, F. C.; Santos, A.; Fernandes, F. C. B.; Bueno, P. R. Sens. Actuators B Chem. 2015, 213, 150. doi: 10.1016/j.snb.2015.02.068
[105]	Luna, D. M.; Oliveira, M. D.; Nogueira, M. L.; Andrade, C. A. Chem. Phys. Lipids 2014, 180, 7. doi: 10.1016/j.chemphyslip.2014.02.008
[106]	Oliveira, M. D.; Correia, M. T.; Diniz, F. B. Biosens. Bioelectron. 2009, 25, 728. doi: 10.1016/j.bios.2009.08.009
[107]	Oliveira, M. D. L.; Nogueira, M. L.; Correia, M. T. S.; Coelho, L. C. B. B.; Andrade, C. A. S. Sens. Actuators B Chem. 2011, 155, 789. doi: 10.1016/j.snb.2011.01.049
[108]	Avelino, K. Y. P. S.; Andrade, C. A. S.; De Melo, C. P.; Nogueira, M. L.; Correia, M. T. S.; Coelho, L. C. B. B.; Oliveira, M. D. L. Synthetic Met. 2014, 194, 102. doi: 10.1016/j.synthmet.2014.05.001
[109]	Andrade, C. A.; Oliveira, M. D.; De Melo, C. P.; Coelho, L. C.; Correia, M. T.; Nogueira, M. L.; Singh, P. R.; Zeng, X. J. Colloid Interf. Sci. 2011, 362, 517. doi: 10.1016/j.jcis.2011.07.013
[110]	Palomar, Q.; Gondran, C.; Marks, R.; Cosnier, S.; Holzinger, M. Electrochim. Acta 2018, 274, 84. doi: 10.1016/j.electacta.2018.04.099
[111]	Luna, D. M. N.; Avelino, K. Y. P. S.; Cordeiro, M. T.; Andrade, C. A. S.; Oliveira, M. D. L. Sens. Actuators B Chem. 2015, 220, 565. doi: 10.1016/j.snb.2015.05.067
[112]	Navakul, K.; Warakulwit, C.; Yenchitsomanus, P. T.; Panya, A.; Lieberzeit, P. A.; Sangma, C. Nanomedicine 2017, 13, 549.
[113]	Deng, J.; Toh, C. S. Sensors 2013, 13, 7774. doi: 10.3390/s130607774
[114]	Jin, S. A.; Poudyal, S.; Marinero, E. E.; Kuhn, R. J.; Stanciu, L. A. Electrochim. Acta 2016, 194, 422. doi: 10.1016/j.electacta.2016.02.116
[115]	Goode, J. A.; Rushworth, J. V.; Millner, P. A. Langmuir 2015, 31, 6267. doi: 10.1021/la503533g
[116]	Janegitz, B. C.; Silva, T. A.; Wong, A.; Ribovski, L.; Vicentini, F. C.; Taboada Sotomayor, M. D. P.; Fatibello Filho, O. Biosens. Bioelectron. 2017, 89, 224. doi: 10.1016/j.bios.2016.03.026
[117]	Oztekin, Y.; Ramanaviciene, A.; Yazicigil, Z.; Solak, A. O.; Ramanavicius, A. Biosens. Bioelectron. 2011, 26, 2541. doi: 10.1016/j.bios.2010.11.001
[118]	Sinawang, P. D.; Rai, V.; Ionescu, R. E.; Marks, R. S. Biosens. Bioelectron. 2016, 77, 400. doi: 10.1016/j.bios.2015.09.048
[119]	Nuzaihan, M. N. M.; Hashim, U.; Md Arshad, M. K.; Kasjoo, S. R.; Rahman, S. F.; Ruslinda, A. R.; Fathil, M. F.; Adzhri, R.; Shahimin, M. M. Biosens. Bioelectron. 2016, 83, 106. doi: 10.1016/j.bios.2016.04.033
[120]	Anusha, J. R.; Fleming, A. T.; Kim, H. J.; Kim, B. C.; Yu, K. H.; Raj, C. J. Bioelectrochemistry 2015, 104, 44. doi: 10.1016/j.bioelechem.2015.02.004
[121]	Krikstolaityte, V.; Kuliesius, J.; Ramanaviciene, A.; Mikoliunaite, L.; Kausaite Minkstimiene, A.; Oztekin, Y.; Ramanavicius, A. Polymer 2014, 55, 1613. doi: 10.1016/j.polymer.2014.02.003
[122]	Bazin, I.; Tria, S. A.; Hayat, A.; Marty, J. L. Biosens. Bioelectron. 2017, 87, 285. doi: 10.1016/j.bios.2016.06.083
[123]	Zhang, S.; Geryak, R.; Geldmeier, J.; Kim, S.; Tsukruk, V. V. Chem. Rev. 2017, 117, 12942. doi: 10.1021/acs.chemrev.7b00088
[124]	Basso, C. R.; Tozato, C. C.; Crulhas, B. P.; Castro, G. R.; Junior, J. P. A.; Pedrosa, V. A. J. Virol. 2018, 513, 85.
[125]	Hasanzadeh, M.; Karimzadeh, A.; Sadeghi, S.; Mokhtarzadeh, A.; Shadjou, N.; Jouyban, A. J. Mater. Sci. Mater. Electron. 2016, 27, 6488. doi: 10.1007/s10854-016-4590-6
[126]	Vermisoglou, E.; Panacek, D.; Jayaramulu, K.; Pykal, M.; Frebort, I.; Kolar, M.; Hajduch, M.; Zboril, R.; Otyepka, M. Biosens. Bioelectron. 2020, 166, 112436. doi: 10.1016/j.bios.2020.112436
[127]	Zhang, W.; Xiao, G.; Chen, J.; Wang, L.; Hu, Q.; Wu, J.; Zhang, W.; Song, M.; Qiao, J.; Xu, C. Anal. Bioanal. Chem. 2021, 413, 2407. doi: 10.1007/s00216-021-03197-8
[128]	Choi, Y.; Hwang, J. H.; Lee, S. Y. Small Methods 2018, 2, 1700351. doi: 10.1002/smtd.v2.4
[129]	Rashid, J. I.; Yusof, N. A.; Abdullah, J.; Hashim, U.; Hajian, R. Mater. Sci. Eng. C Mater. Biol. Appl. 2014, 45, 270. doi: 10.1016/j.msec.2014.09.010
[130]	Zhang, L.; Gu, C.; Wen, J.; Liu, G.; Liu, H.; Li, L. Anal. Bioanal. Chem. 2021, 413, 83. doi: 10.1007/s00216-020-03000-0
[131]	Fu, J.; Wu, J.; Zhang, R.; Wu, Q.; Ju, H. Sens. Actuators B Chem. 2021, 345, 130436. doi: 10.1016/j.snb.2021.130436
[132]	Sinawang, P. D.; Fajs, L.; Elouarzaki, K.; Nugraha, J.; Marks, R. S. Sens. Actuators B Chem. 2018, 259, 354. doi: 10.1016/j.snb.2017.12.043
[133]	Lim, J. M.; Kim, J. H.; Ryu, M. Y.; Cho, C. H.; Park, T. J.; Park, J. P. Anal. Chim. Acta 2018, 1026, 109. doi: 10.1016/j.aca.2018.04.005
[134]	Palomar, Q.; Xu, X.; Gondran, C.; Holzinger, M.; Cosnier, S.; Zhang, Z. Mikrochim. Acta 2020, 187, 363. doi: 10.1007/s00604-020-04339-y
[135]	Cecchetto, J.; Santos, A.; Mondini, A.; Cilli, E. M.; Bueno, P. R. Biosens. Bioelectron. 2020, 151, 111972. doi: 10.1016/j.bios.2019.111972
[136]	Khristunova, E.; Dorozhko, E.; Korotkova, E.; Kratochvil, B.; Vyskocil, V.; Barek, J. Sensors 2020, 20, 4600. doi: 10.3390/s20164600
[137]	Nascimento, H. P.; Oliveira, M. D.; De Melo, C. P.; Silva, G. J.; Cordeiro, M. T.; Andrade, C. A. Colloids Surf. B 2011, 86, 414. doi: 10.1016/j.colsurfb.2011.04.028
[138]	Solanki, S.; Soni, A.; Pandey, M. K.; Biradar, A.; Sumana, G. ACS Appl. Mater. Inter. 2018, 10, 3020. doi: 10.1021/acsami.7b14391
[139]	Wasik, D.; Mulchandani, A.; Yates, M. V. Sensors 2018, 18, 2641. doi: 10.3390/s18082641
[140]	Senapati, S.; Slouka, Z.; Shah, S. S.; Behura, S. K.; Shi, Z.; Stack, M. S.; Severson, D. W.; Chang, H. C. Biosens. Bioelectron. 2014, 60, 92. doi: 10.1016/j.bios.2014.04.008

登革热病毒检测的生物传感技术

Biosensing Technology for Dengue Virus Detection

RichHTML

PDF

可视化

摘要/Abstract

引用此文

分享此文

图/表 12

参考文献 140

相关文章 15

编辑推荐

相关统计

本文评价

[1]	李兰英, 陶晴, 闻艳丽, 王乐乐, 郭瑞妍, 刘刚, 左小磊. 多聚腺嘌呤DNA探针及其生物传感应用^★[J]. 化学学报, 2023, 81(6): 681-690.
[2]	朱子煜, 梁阿新, 浩天瑞霖, 唐珊珊, 刘淼, 解炳腾, 罗爱芹. 生物传感器在新冠病毒检测中的应用[J]. 化学学报, 2023, 81(3): 253-263.
[3]	浩天瑞霖, 朱子煜, 蔡艳慧, 王微, 王祯, 梁阿新, 罗爱芹. 基于共价有机框架的电化学生物传感器在生物样品检测中的应用[J]. 化学学报, 2022, 80(11): 1524-1535.
[4]	廖妮, 钟霞, 梁文斌, 袁若, 卓颖. ECL金属-有机框架(MOF)生物传感平台用于肿瘤细胞分泌H₂O₂的测定[J]. 化学学报, 2021, 79(10): 1257-1264.
[5]	金鑫, 王晓英. 口腔癌相关唾液肿瘤生物标志物的分析检测研究进展[J]. 化学学报, 2019, 77(4): 340-350.
[6]	胡正利, 杜冀晖, 应佚伦, 彭岳一, 曹婵, 龙亿涛. 纳米孔道单分子检测结直肠癌MicroRNAs[J]. 化学学报, 2017, 75(11): 1087-1090.
[7]	刘兴奋, 王亚腾, 黄艳琴, 冯晓苗, 范曲立, 黄维. 基于水溶性共轭聚合物分子刷的高灵敏凝血酶生物传感器[J]. 化学学报, 2016, 74(8): 664-668.
[8]	张佳佳, 代佩卿, 李超, 李南忘, 程圭芳, 何品刚, 方禹之. 基于磁纳米颗粒的二段对称分裂式G-四分体DNA酶生物传感器用于Hg²⁺的快速检测[J]. 化学学报, 2014, 72(9): 1029-1035.
[9]	吴星怡, 张磊, 吕丹, 刘艳华, 陈亚南, 苏位君, 罗娜, 向荣. 表面等离子体共振传感器在癌症早期诊断中的应用[J]. 化学学报, 2013, 71(03): 299-301.
[10]	吴超, 杨胜园, 吴朝阳, 沈国励, 俞汝勤. 基于裂开型核酸适配体的液晶生物传感检测三磷酸腺苷[J]. 化学学报, 2013, 71(03): 367-370.
[11]	杨绍明, 查文玲, 李红, 孙清, 郑龙珍. 非标记型双底物检测核酸适配体传感器研究[J]. 化学学报, 2013, 71(03): 451-456.
[12]	应佚伦, 张星, 刘钰, 薛梦竹, 李洪林, 龙亿涛. 纳米通道单分子检测P53蛋白与DNA的弱相互作用[J]. 化学学报, 2013, 71(01): 44-50.
[13]	夏前芳, 罗丹, 李在均. 石墨烯基葡萄糖生物传感器的电化学制备及应用[J]. 化学学报, 2012, 70(19): 2079-2084.
[14]	王青, 朱红志, 羊小海, 王柯敏, 杨丽娟, 丁静. 纳米金颗粒增强信号的表面等离子体共振生物传感器用于甲氧檗因高灵敏检测的研究[J]. 化学学报, 2012, 70(13): 1483-1487.
[15]	董晓娅, 赵伟伟, 孙国宝, 徐静娟, 陈洪渊. 基于纳米金膜和稳定Y型结构的DNA电化学传感器[J]. 化学学报, 2012, 70(13): 1457-1463.