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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (17): 1869-1874. 上一篇    下一篇

研究论文

两个单环有机过氧化物的合成

张琦, 刘鹤华, 伍贻康*   

  1. (中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032)
  • 投稿日期:2007-06-08 修回日期:2007-07-11 发布日期:2007-09-14
  • 通讯作者: 伍贻康

Synthesis of Two Monocyclic Organic Peroxides

ZHANG Qi; LIU He-Hua; WU Yi-Kang*   

  1. (State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemis-try, Chinese Academy of Sciences, Shanghai 200032)
  • Received:2007-06-08 Revised:2007-07-11 Published:2007-09-14
  • Contact: WU Yi-Kang

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报道了两个新的环状有机过氧化物. 在1,2-二氧六环化合物的合成中, 首次探讨了利用对三取代碳—碳双键的分子内Michael加成来完成过氧环环合的可能性. 在1,2-二氧七环的合成中由于无法利用Michael加成来完成七元过氧环环合, 采用了汞离子媒介的反应来实现七元过氧环的构建.

关键词: 过氧化物, 抗疟, 合成, 双氧水, 螺环化合物

Two new cyclic peroxides are reported. The peroxy bond in each compound was derived from hydrogen peroxide. The synthesis of the first compound explored the feasibility of using an intramolecular Michael addition to a trisubstituted C—C double bond to close the peroxy ring, while that of the second utilized a Hg(II)-mediated ring-closure to construct the seven-membered peroxy ring.

Key words: peroxide, antimalarial, synthesis, hydrogen peroxide, cyclization