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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (8): 678-682. 上一篇    下一篇

研究论文

稀土与华法灵、水杨酸三元配合物的合成和抗凝血作用研究

宋玉民*,1, 董银龙1, 付云龙2, 姚卡玲2   

  1. (1西北师范大学化学化工学院 兰州 730070)
    (2兰州大学化学化工学院 兰州 730000)
  • 投稿日期:2006-07-15 修回日期:2006-11-10 发布日期:2007-04-28
  • 通讯作者: 宋玉民

Study on Syntheses and Anticoagulant Action of Rare Earth Ternary Complexes with Warfarinanion and Salicylate

SONG Yu-Min*,1; DONG Yin-Long1; FU Yun-Long2; YAO Ka-Ling2   

  1. (1 College of Chemistry and Chemical Engineering, Northwest Normal University, Lan-zhou 730070)
    (2 College of Chemistry and Chemical Engineering, Lanzhou Univer-sity, Lanzhou 730000)
  • Received:2006-07-15 Revised:2006-11-10 Published:2007-04-28
  • Contact: SONG Yu-Min

PDF

978

被引次数

68 | 15

用氯化稀土与华法灵钠、水杨酸钠在不同介质中制备了稀土三元配合物, 所试验各种制备方法均可获得恒定组成的配合物REL2L'•2H2O (HL＝华法灵离子; HL'＝水杨酸离子). 通过元素分析、红外光谱、核磁共振氢谱、X射线衍射、摩尔电导、电子吸收光谱和溶解性试验对配合物进行了表征. 抗凝血试验表明稀土三元配合物具有优良的抗凝血性质.

关键词: 稀土, 三元配合物, 华法灵, 水杨酸, 抗凝血作用

The rare earth ternary complexes have been prepared with rare earth chlorides, warfarinanion sodium and sodium salicylate. The above complexes have constant composition of REL2L'•2H2O (L＝warfarinanion, L'＝salicylate) prepared by different synthesis methods, and have been characterized by elemental analysis, IR, 1H NMR spectra, X-ray diffraction, molar conductivity, electronic absorption spectrum and solubility. The rare earth ternary complexes all have nice anticoagulant action in related experiments.

Key words: rare earth, ternary complex, warfarinanion, salicylate, anticoagulant action