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化学学报
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化学学报 ›› 2005, Vol. 63 ›› Issue (13): 1225-1230. 上一篇    下一篇

研究论文

配合物[Pd(L-tyr)2]•0.5H2O的晶体结构、稳定性及其与DNA作用研究

高恩君*1，李浩洋1，刘祁涛2   

  1. (1沈阳化工学院配位化学研究室 沈阳 110142)
    (2辽宁大学化学科学与工程学院 沈阳 110036)
  • 投稿日期:2004-08-06 修回日期:2005-03-04 发布日期:2010-12-10
  • 通讯作者: 高恩君

Study on Crystal Structure, Stability and the Interaction of Complex [Pd(L-tyr)2]•0.5H2O with DNA

GAO En-Jun*1, LI Hao-Yang1, LIU Qi-Tao2   

  1. (1 Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142)
    (2 Institute of Chemical Science and Engineering, Liaoning University, Shenyang 110036)
  • Received:2004-08-06 Revised:2005-03-04 Published:2010-12-10
  • Contact: GAO En-Jun

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合成了配合物[Pd(L-tyr)2]•0.5H2O单晶(L-tyr－为酪氨酸根). 配合物属于单斜晶系, P2(1)空间群. L-tyr－的羧基氧原子和氨基氮原子与Pd(II)离子配位, 形成两个五元螯合环的平面结构. 配合物分子之间存在配位螯合环-配位螯合环的弱相互作用、苯酚环-苯酚环之间的π-π堆积作用以及水分子与配体之间的氢键作用. 水溶液中配合物的累积稳定常数为1017数量级, 表明配体与离子形成较强的配位共价键. 配合物与鱼精DNA作用的紫外光谱、CD光谱和荧光光谱表明, 两者之间有较强的相互作用, 并以插入作用方式为主.

关键词: 钯(II), 酪氨酸, 结构, 稳定性, DNA

A single crystal of [Pd(L-tyr)2]•0.5H2O was synthesized, and it belongs to monoclinic system with space group P2(1). Oxygen atom of carboxyl and nitrogen atom of azyl coordinate with Pd(II) ion to form two planar five-membered rings. There were weak interaction between one coordinate chelate ring and another coordinate chelate ring, π-π stacking between phenolic rings and hydrogen bonds between water molecule and ligand. In water solution, cumulative stability constant β2 of title complex is 1017, and it means that there was strong coordinate-covalent bond between ligand and Pd(II) ion. The interaction of the complex with fish sperm DNA has been studied by UV, fluorescence and CD. The results show that the interaction of the complex with DNA took mainly insertion mode and there was strong interaction between complex and DNA.

Key words: palladium(II), tyrosine, structure, stability constant, DNA