化学学报 ›› 2012, Vol. 70 ›› Issue (24): 2475-2483.DOI: 10.6023/A12090702 上一篇    下一篇

综述

水溶性卟啉及金属卟啉在DNA中的研究进展

张现侠, 陈灿玉   

  1. 杭州师范大学材料与化学化工学院 杭州 310036
  • 收稿日期:2012-09-24 出版日期:2012-12-28 发布日期:2012-11-14
  • 通讯作者: 陈灿玉 E-mail:chency@hznu.edu.cn
  • 基金资助:
    项目受杭州市科技发展计划项目(No. 20100933B10)、杭州师范大学科研基金(No. 2011PYJJ09)和浙江省医药卫生科技项目(No. 2012KYB161)资助.

Development of Study on Water-Soluble Porphyrins and Metalloporphyrins in DNA

Zhang Xianxia, Chen Canyu   

  1. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036
  • Received:2012-09-24 Online:2012-12-28 Published:2012-11-14
  • Supported by:
    Project supported by Program for Technological Development of Hangzhou (No. 20100933B10) and Science Foundation of Hangzhou Normal University (No. 2011PYJJ09) and Technological Program for Health Bureau of Zhejiang Province (No. 2012KYB161).

近年来, 卟啉及金属卟啉与DNA的相互作用已成为研究的热点. 通过对卟啉及金属卟啉与DNA相互作用的研究将有助于更深地认识DNA本身的结构和功能, 有助于卟啉及金属卟啉在医学上的应用, 对认识很多疾病的治病机制和药物的设计也起到非常重要的作用. 本文阐述了卟啉及金属卟啉与DNA相互作用的方式和影响因素, 并将水溶性卟啉及金属卟啉分为三类: 具有吡啶基或铵基的阳离子型卟啉及金属卟啉, 具有磺酸基或羧基的阴离子型卟啉及金属卟啉, 以及非离子型的卟啉及金属卟啉. 重点论述了这三类水溶性卟啉及金属卟啉与DNA之间的相互作用, 以及这三类水溶性卟啉及金属卟啉在DNA中的应用研究进展.

关键词: 水溶性, 卟啉, 金属卟啉, DNA, 研究进展

The research of the interaction between porphyrins or metalloporphyrins and DNA becomes one focal point in recent years. The research conduces to realize the structure and the function of DNA more deeply, and profits porphyrins or metalloporphyrins to use in the medicine, and also be very important for understanding the treatment mechanism and the drug design of many diseases. The mode and influencing factors of interaction between porphyrins or metalloporphyrins and DNA are elucidated, and the water-soluble porphyrins and metalloporphyrins are classified into three types: the cationic porphyrins and metalloporphyrins which have pyridyl group or ammonium group, the anionic porphyrins and metalloporphyrins which have sulfonic group or carboxyl group, and the neutral porphyrins and metalloporphyrins. The interaction and the recent exploratory development in the study of the three types of the water-soluble porphyrins and metalloporphyrins in DNA are emphatically reviewed.

Key words: water-soluble, porphyrins, metalloporphyrins, DNA, development