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化学学报
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化学学报 ›› 1957, Vol. 23 ›› Issue (6): 447-454. 上一篇    下一篇

论文

血吸虫病化学治疗的研究Ⅳ.二巯基丙醇的芳基醚及其锑硫醇鹽

谢毓元, 朱應麒, 黄知恒, 楊行忠, 周啓霆, 嵇汝運   

  1. 中国科学院藥物研究所
  • 投稿日期:1957-05-30 发布日期:2013-06-03

CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS Ⅳ. SOME ARYL ETHERS OF DIMERCAPTOPROPANOL AND THEIR A NTIMONIAL MERCAPTIDES

HSIEH YU-YUAN, CHUE YING-CHI, HUANG CHIH-HENG, YANG IN-TSON, CHOW CHI-TING, KYI ZU-YOONG   

  1. Institute of Materia Medica, Academia Sinica, Shanghai
  • Received:1957-05-30 Published:2013-06-03

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3

对位上具有不同取代基团的芳某丙烯基醚加溴生成相应的芳基、2,3-二溴丙基醚。这些新化合物与硫化氫鉀(或鈉)作用,其中对甲基、对溴及对氨基苯基、2,3-二溴丙基醚形成相应的2,3-二巯基丙基醚;对羧基化合物在冷甲醇液中也可形成二巯基化合物,但在冷水溶液中不起作用,热水溶液中則醚鍵發生水解,不能生成二巯基丙基醚;对硝基及对磺酰氨基化合物在甲醇液中冷时作用醚鍵也遭致水解。制得的四种二巯基丙醚与三氯化銻作用,并再將氯原子水解为羟基,生成相应的4-芳氧甲某-4,5-二氫-2-羟基-1,3-二間硫銻杂茂(4-Aryloxymethyl-4,5-dihydro-2-hydroxy-1,3-dithiastibiol)。

Potassium antimonyltartrate is so far the only remedy for schistosomaisis in Chima.This drug is rather togi.c and has a number of side actions.Although 2,3-ditnercaptopropanol (Ⅰ) is an activo antidote against arsenic and many othor heavy metals,it detogicates potassium antimonyltartrate less effectively.A change in its pharmacological activity might bo caused by varrying its chemical structure,and several aryl ethers (Ⅱ) havo therefore been synthesized in the present work.