Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (02): 183-189.DOI: 10.6023/A1109091 Previous Articles     Next Articles

Full Papers


潘成学a,b, 关一富b, 张洪彬b   

  1. a 广西师范大学化学化工学院 药用资源化学与药物分子工程国家重点实验室培育基地 桂林 541004;
    b 云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091
  • 投稿日期:2011-09-09 修回日期:2011-10-18 发布日期:2012-02-25
  • 通讯作者: 张洪彬;
  • 基金资助:

    国家973 重大基础研究计划子项目(No.2009CB522300)资助项目.

Synthesis of a Brazilin Analog

Pan Chengxuea,b, Guan Yifub, Zhang Hongbinb   

  1. a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004;
    b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming 650091
  • Received:2011-09-09 Revised:2011-10-18 Published:2012-02-25
  • Supported by:

    National Basic Research Program of China (973 Program, No.2009CB522300).

In this paper the synthesis of a brazilin analog starting from 3-(3,4-dimethoxy-phenyl)-propionic acid is reported. The synthetic route was finished in 10 steps including intramolecular Friedel-Crafts acylation, dihydroxylation, Lombardo reaction, oxidation with hypervalent iodine compounds, semipinacol rearrangement reaction and so on.

Key words: brazilin, natural product analog, synthesis