Acta Chim. Sinica ›› 2016, Vol. 74 ›› Issue (4): 312-329.DOI: 10.6023/A16010016 Previous Articles     Next Articles



高玉霞a, 胡君b, 巨勇a   

  1. a. 清华大学化学系 生命有机磷化学及化学生物学教育部重点实验室 北京 100084;
    b. 中国科学院长春应用化学研究所 高分子物理与化学国家重点实验室 长春 130022
  • 投稿日期:2016-01-08 发布日期:2016-03-03
  • 通讯作者: 巨勇
  • 基金资助:

    项目受国家自然科学基金(No. 21472108)、国家重大科学研究计划(973计划, No. 2012CB821600)和高分子物理与化学国家重点实验室开放课题基金资助.

Supramolecular Self-Assembly Based on Natural Small Molecules

Gao Yuxia, Hu Junb, Ju Yonga   

  1. a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084;
    b State Key Lab of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022
  • Received:2016-01-08 Published:2016-03-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21472108), the National Basic Research Program of China (973 Program, No. 2012CB821600), and Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, CIAC.

Natural products have been widely used in the construction of supramolecular self-assemblies due to not only their abundant resources, unique chiral structures, and multiple reaction sites, but also the good biocompatibility and the controllable degradability. Through the simple chemical modification natural products-based functional molecules would self-assemble into various supramolecular assemblies primarily promoted by non-covalent interactions, such as hydrogen bonding, π-π stacking, van der Waals forces, electrostatic interactions, and charge-transfer interactions. During the assembly process, their unique molecular chirality would be transferred and magnified into supramolecular assemblies, thus providing a facile method to fabricate helical ribbons, nanotubes, and other chiral nanostructures. Furthermore, their good biocompatibility and biological activity endow the assemblies with the ability to be widely applied in tissue engineering, drug delivery, cell imaging, and so on. In this review, recent developments of supramolecular self-assemblies based on amino acids, sugars, nucleosides, steroids, triterpenoids and other natural products were summarized.

Key words: natural small molecules, supramolecular self-assembly, non-covalent interactions, chirality, biological activity