Solid-liquid phase transfer catalytic synthesis V. Michael addition , carbonyl addition reactions of aldimines for the synthesis of \a\-amino acids

Acta Chimica Sinica ›› 1987, Vol. 45 ›› Issue (10): 997-1001. Previous Articles Next Articles

Original Articles

固-液相转移催化合成V.醛亚胺的michael加成和羰基加成反应合成α-氨基酸

邬胜德;周昌友;刘桂兰;邓润华;蒋耀忠

中国科学院成都有机化学研究所

发布日期:1987-10-15

Solid-liquid phase transfer catalytic synthesis V. Michael addition , carbonyl addition reactions of aldimines for the synthesis of \a\-amino acids

WU SHENGDE;ZHOU CHANGYOU;LIU GUILAN;DENG RUNHUA;JIANG YAOZHONG

Published:1987-10-15

Abstract

Michael addition of 4-R1C6H4CH:NCHR2CO2R3 (I; R1 = H, Cl; R2 = H, Me; R3 = Me, Et) with R4CH:CHR5 (R4 = H, Ph; R5 = CO2Me, cyano), PhCH2NEt3Cl, K2CO3 in MeCN gave 4-R1C6H4CH:NCR2(CO2R3)CHR4CH2R5. Addition reaction of I (R1 = Cl, R2 = H, Me, R3 = Me, Et) with R6CHO (R6 = H, Ph, 4-ClC6H4, 4-O2NC6H4) gave oxazolidines II, hydrolysis of which gave R6CH(OH)CR2(NH2)CO2H.

Key words: AMINO ACID, HYDROLYSIS, ALKENE, POTASSIUM CARBONATE, PHASE TRANSFER CATALYSIS, ALANINE, ALDEHYDES, ADDITION REACTION, GLYCINE, SERINE

CLC Number:

O621

Cite this article

WU SHENGDE;ZHOU CHANGYOU;LIU GUILAN;DENG RUNHUA;JIANG YAOZHONG. Solid-liquid phase transfer catalytic synthesis V. Michael addition , carbonyl addition reactions of aldimines for the synthesis of \a\-amino acids[J]. Acta Chimica Sinica, 1987, 45(10): 997-1001.

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固-液相转移催化合成V.醛亚胺的michael加成和羰基加成反应合成α-氨基酸

Solid-liquid phase transfer catalytic synthesis V. Michael addition , carbonyl addition reactions of aldimines for the synthesis of \a\-amino acids

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固-液相转移催化合成V.醛亚胺的michael加成和羰基加成反应合成α-氨基 酸

Solid-liquid phase transfer catalytic synthesis V. Michael addition , carbonyl addition reactions of aldimines for the synthesis of \a\-amino acids

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

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Comments

固-液相转移催化合成V.醛亚胺的michael加成和羰基加成反应合成α-氨基酸