One pot synthesis of trifluoromethyl substituted olefins by using Ph3P/CF3CCl3 as a new carbonyl olefination reagents

Acta Chimica Sinica ›› 1989, Vol. 47 ›› Issue (4): 360-366. Previous Articles Next Articles

Original Articles

Ph3P/CF3CCl3作为一个新的羰基烯烃化试剂的研究—一锅法合成烯烃RCH=CClCF3

李兴亚;傅伟敏;麻生明;蒋锡夔

中国科学院上海有机化学研究所

发布日期:1989-04-15

One pot synthesis of trifluoromethyl substituted olefins by using Ph3P/CF3CCl3 as a new carbonyl olefination reagents

LI XINGYA;FU WEIMIN;MA SHENGMING;JIANG XIKUI

Published:1989-04-15

Abstract

A one-pot synthesis of trifluoromethyl olefins by reactions of Ph3P/CF3CCl3 with aldehydes at room temperature was reported. The reactions with aromatic and a,b-unsatd. aliphatic aldehydes are highly stereoselective and give Z isomers while the reactions with other aliphatic aldehydes give Z and E isomers in 2:1 to 3:1 ratios.

Key words: CHLOROHYDROCARBON, ALKENE, WITTIG REACTION, TRIPHENYLPHOSPHINE, HALOHYDROCARBON, ALDEHYDES, FLUOROHYDROCARBON, CHEMICAL REAGENT, CARBONYL GROUP, ETHANE P

CLC Number:

O627

Cite this article

LI XINGYA;FU WEIMIN;MA SHENGMING;JIANG XIKUI. One pot synthesis of trifluoromethyl substituted olefins by using Ph3P/CF3CCl3 as a new carbonyl olefination reagents[J]. Acta Chimica Sinica, 1989, 47(4): 360-366.

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Ph3P/CF3CCl3作为一个新的羰基烯烃化试剂的研究—一锅法合成烯烃RCH=CClCF3

One pot synthesis of trifluoromethyl substituted olefins by using Ph3P/CF3CCl3 as a new carbonyl olefination reagents

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