Acta Chimica Sinica ›› 1995, Vol. 53 ›› Issue (6): 620-624. Previous Articles    

Original Articles

从尿核苷合成异胞苷衍生物的简便有效方法

曾福金   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1995-06-15

A simple and efficient method for synthesis of isocytidine derivatives from uridine

ZENG FUJIN   

  • Published:1995-06-15

Isocytidine derivatives (4~8) has been synthesized in reasonable yield in one step by reaction of uridine derivatives 1,2 and 3 with alkylamine in the presence of triethylamine at room temperature, while the reaction of 5'-O-(p-tolylsulfonyl)-uridine with isopropylamine gives 5'-deoxy-5'-isopropylaminouridine is same conditions. A plausible mechanism of the reaction is proposed.

Key words: SYNTHESIS

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