Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (19): 2319-2327. Previous Articles     Next Articles

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  1. (1 淮海工学院化学工程学院 连云港 222005)
    (2 淮海工学院数理学院 连云港 222005)
    (3 聊城大学化学工程学院 聊城 252059)
    ( 4北京大学医学部基础医学院药理系及国家天然仿生药物重点实验室 北京 100191)
  • 投稿日期:2011-04-19 修回日期:2011-05-24 发布日期:2011-06-02
  • 通讯作者: 杨树平
  • 基金资助:


Solvothermal Synthesis, Crystal Structure of a 1D Coordination Polymer [Er(CCA)3(H2O)2]n•2nH2O (HCCACoumarin-3-Carboxylic Acid) and the Interaction between the Polymer and Bovine Serum Albumin (BSA)

Yang Shuping*,1 Han Lijun2 Wang Daqi3 Pan Yan4 Yu Zhiqun1 Ye Haiyan1   

  1. (1 School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005)
    (2 School of Mathematics and Science, Huaihai Institute of Technology, Lianyungang 222005)
    (3 School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059)
    (4 State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Institute of System Biomedicine, Peking University, Beijing 100191)
  • Received:2011-04-19 Revised:2011-05-24 Published:2011-06-02
  • Contact: Shu-Ping YANG

A coordination polymer [Er(CCA)3(H2O)2]n•2nH2O (HCCA=coumarin-3-carboxylic acid) has been prepared by solvent-thermal method and characterized by elemental analysis and IR spectra and single crystal X-ray diffraction. The crystal of erbium(III) complex belongs to monoclinic system with space group, P21/c, a=0.6310(1) nm, b=1.4165(2) nm, c=3.1731(3) nm|β=91.861(2)°, V=2.8346(7) nm3, Dc=1.890 g•cm-3, Z=4, F(000)=1596, residual factors R1=0.0525, wR2=0.0930 [I>2σ(I)], S=1.290. The Er(III) atom is eight-coordinated by eight O atoms from three ligands (CCA) and two coordinated water molecules, and the coordination polyhedron around the Er(III) atom can be best described as a distorted dodecahedron geometry. Two adjacent Er(III) atoms were bridged into a one-dimensional polymeric chain by the carboxylic group in a ligand (CCA). The interaction between complex and bovine serum albumin (BSA) was investigated by fluorescence spectroscopy at different temperature. The results indicated that the complex quenches the fluorescence of BSA through a static quenching procedure. The binding constants (Ka) and the number of binding sites (n) between the complex and BSA were calculated at different temperature. The corresponding thermodynamic parameters enthalpy changes (ΔH>0) and entropy changes (ΔS>0) were also obtained according to the vant Hoff equation. The primary binding pattern between complex and BSA was interpreted as hydrophobic interaction. The binding average distance r between the donor (BSA) and acceptor (complex) was obtained to be 2.85 nm based on the F?sters theory, which indicates the non-radiation energy transfer can occur from BSA to complex with high probability.

Key words: erbium(III) coordination polymer, coumarin-3-carboxylic acid, crystal structure, bovine serum albumin (BSA), fluorescence spectra, solvent-thermal method