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Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (6): 555-563. Previous Articles     Next Articles

Original Articles

配合物[RE2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O的合成、 晶体结构及其与DNA作用方式初探

陈凤英a,b 何水样*,a 刘 峰a 王刘杰a

  

  1. (a西北大学化学系 陕西省物理无机化学重点实验室 西安 710069)
    (b商洛学院化学系 商洛 726000)

  • 投稿日期:2008-05-12 修回日期:2008-11-21 发布日期:2009-03-28
  • 通讯作者: 何水样

Synthesis, Crystal Structure and Preliminary DNA-binding Studies of [RE2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O

Chen, Fengying a,b He, Shuiyang *,a Liu, Feng a Wang, Liujie a   

  1. (a Shaanxi Key Laboratory of Physico-inorganic Chemistry, Department of Chemistry, Northwest University, Xi’an 710069)
    (b Department of Chemistry, Shangluo University, Shangluo 726000)

  • Received:2008-05-12 Revised:2008-11-21 Published:2009-03-28
  • Contact: He, Shuiyang

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Complex 1 [Pr2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O and complex 2 [Eu2(H2L)2(HL)2(2,6- H2PDA)(H2O)2]•2H2O were obtained by reactions of N-(2-propionic acid)-salicyloyl hydrazone (C10H10N2O4, H3L), 2,6-pyridinedicarboxylic acid (2,6-H2PDA) and RE(NO3)3•nH2O (RE＝Pr, Eu) at room temperature, and characterized by elemental analyses, IR, UV, and single crystal X-ray diffractometry. In addition, the DNA binding properties of the two complexes were studied by means of UV absorption spectrum, emission spectroscopic spectrum, steady-state emission quenching and DNA competitive binding with ethidium bromide (EB). The results indicated that the two complexes bound to calf-thymus DNA in an intercalative mode.

Key words: rare earth, N-(2-propionic acid)-salicyloyl hydrazone, 2,6-pyridinedicarboxylic acid, crystal structure, calf-thymus DNA