Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (11): 1217-1222. Previous Articles     Next Articles

Original Articles


杨 波 于广利* 王玉峰 赵 峡 王 皓
胡艳南 嵇国利


  1. (中国海洋大学医药学院 糖科学与糖工程实验室 青岛 266003)

  • 投稿日期:2008-11-03 修回日期:2009-02-10 发布日期:2009-06-14
  • 通讯作者: 于广利

Synthesis and Structural Analysis of κ-carrageenan Derived Oligosaccharide Neoglycolipids

Yang, Bo Yu, Guangli* Wang, Yufeng Zhao, Xia Wang, Hao
Hu, Yannan Ji, Guoli

  1. (Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China,
    Qingdao 266003)
  • Received:2008-11-03 Revised:2009-02-10 Published:2009-06-14
  • Contact: Yu, Guangli

Five oligosaccharides were obtained from κ-carrageenan mild acid hydrolysate with gel filtration chromatography, which were linked to dipalmitoyl phosphatidylethanolamine (DPPE) by a reductive animation reaction to acquire five neoglycolipids. With a high-sensitivity electrospray ionization collision induced tandem mass spectrometry (ESI-CID-MS/MS) technique, the sequence and structure of these neoglycolipids were identified as κ-carrageenan derived trisaccharide, pentasaccharide, heptasaccharide, nonasaccharide and undecasaccharide-glycolipids, respectively. The results provide a good reference for synthesis of sulfated-neoglycolipid, and importantly, a basis for the preparation of the oligosaccharide-chip and the deep study on oligosaccharide-protein interactions.

Key words: κ-carrageenan oligosaccharide, neoglycolipid, synthesis, ESI-CID-MS/MS

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