Acta Chimica Sinica ›› 2001, Vol. 59 ›› Issue (10): 1667-1674. Previous Articles     Next Articles

Original Articles

新型双膦配体及钯催化的烯丙基烷基化反应用于构筑季碳手 性中心

游书力;朱霞珍;候雪龙;戴立信   

  1. 中国科学院上海有机化学研究所.上海(200032);中国科学院金属有机化学国家 重点实验室
  • 发布日期:2001-10-15

Synthesis of novel diphosphine ligands and their application in palladium-catalyzed allylic alkylation to construct chiral quaternary carbon center

You Shuli;Zhu Xiazhen;Hou Xuelong;Dai Lixin   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:2001-10-15

Planar chiral ferrocene modified pocket ligands (R, R, Sp, Sp) -4 and (S, S, Sp, Sp)-4 were synthesized from (Sp)-1. The ligands were found to be effective in palladium-catalyzed asymmetric allylic alkylation to construct chiral quaternary carbon center. The poducts up 75.3% ee by using iminoesters as a carbon nucleophile and up to 95% ee by using the simple ketone enolates as a carbon nucleophile were afforded, respectively.

Key words: PHOSPHINE, LIGANDS, PALLADIUM, CATALYTIC REACTION, ALLYL GROUP, ALKYLATION, FERROCENE

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