Study on Synthesis, Characterization, Crystal Structure and in vitro Antitumour Activity of Di-n-Butyltin Bis-Ferrocenethiocarboxylate Complex

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (2): 160-164. Previous Articles Next Articles

二正丁基锡(Ⅳ)双(二茂铁硫代甲酸酯)配合物的合成、结构表征及其体外抗癌活性研究

卢文贯¹, 陶家洵², 王大奇³

1. 韶关学院化学系, 韶关, 512005;
2. 清华大学化学系, 北京, 100084;
3. 聊城大学化学系, 聊城, 252059

投稿日期:2003-06-06 修回日期:2003-08-06 发布日期:2014-01-26
通讯作者: 卢文贯,E-mail:lwg@sgu.edu.cn E-mail:lwg@sgu.edu.cn

Study on Synthesis, Characterization, Crystal Structure and in vitro Antitumour Activity of Di-n-Butyltin Bis-Ferrocenethiocarboxylate Complex

LU Wen-Guan¹, TAO Jia-Xun², WANG DaQi³

1. Department of Chemistry, Shaoguan University, Shaoguan 512005;
2. Department of Chemistry, Tsinghua University, Beijing 100084;
3. Department of Chemistry, Liaocheng University, Liaocheng 252059

Received:2003-06-06 Revised:2003-08-06 Published:2014-01-26

Abstract

A novel complex (n-Bu)₂Sn(FcCOS)₂[Fc=(η⁵ C₅H₅)Fe(η⁵C₅H₄)] has been synthesized by the reaction of (n-Bu)₂SnO with FcCOSH. The structure was characterized by elemental analysis, IR and NMR (¹H, ¹³C and ¹¹⁹Sn) spectroscopies. The crystal structure was determined by X ray single crystal diffraction analysis. The results show that the complex is tetragonal with space group P4 2.1 m, the unit cell parameters are as follows: a=2.3351(7) nm, b=2.3351(7) nm, c=0.5870(2) nm, V=3.2005(18) nm³, Z=4, D_c=1 501 Mg/m³, μ(MoKα)=1 823 mm^-1, F (000)=1464. The structure was refined to final R₁=0.0733, wR₂=0.1173. In the crystal of the title complex, the tin atoms rendered six coordination in a distorted octahedral geometry structure, two oxygen atoms and two sulphur atoms formed the equatorial plane and C(12)—Sn(1)—C(16) made the axis. The in vitro antitumour activity of the novel complex has been tested and the result shows that the novel complex exhibits better antitumour activity in vitro against HL 60, HCT 8, BGC 823 and KB tumour cells.

Key words: diorganotin complex, ferrocenethiocarboxylic acid, synthesis, crystal structure, antitumour activity

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LU Wen-Guan, TAO Jia-Xun, WANG DaQi. Study on Synthesis, Characterization, Crystal Structure and in vitro Antitumour Activity of Di-n-Butyltin Bis-Ferrocenethiocarboxylate Complex[J]. Acta Chimica Sinica, 2004, 62(2): 160-164.

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二正丁基锡(Ⅳ)双(二茂铁硫代甲酸酯)配合物的合成、结构表征及其体外抗癌活性研究

Study on Synthesis, Characterization, Crystal Structure and in vitro Antitumour Activity of Di-n-Butyltin Bis-Ferrocenethiocarboxylate Complex

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