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有机化学
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有机化学 ›› 1990, Vol. 10 ›› Issue (1): 30-36. 上一篇    下一篇

研究论文

1-甲氧基-2-乙氧甲基-3,8--二羟基蒽醌的合成

俞菊荣;蔡俊超;高怡生   

  1. 中国科学院上海药物研究所
  • 发布日期:1990-02-25

Synthesis f 3,8-dihydroxy-2-ethoxymethyl-1-methoxyanthraquinone

YU JURONG;CAI JUNCHAO;GAO YISHENG   

  • Published:1990-02-25

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本文报导了1-甲氧基-2-乙氧甲基-3,8-二羟基蒽醌及其异构体1,3-二羟基-2-乙氧甲基-8-甲氧基蒽醌的合成。

关键词: 乙氧基, 二羟基, 蒽醌 P, 甲氧基, 抗肿瘤药, 茜草

The title compound I and derivatives were prepared from 4-acetoxy-3-bromophthalide and dimethoxytoluene in 9 steps. I showed antitumor activity against leukemia P388 cell in vitro. The inhibitory rates were 85.7%, 58.7%, and 42.9% at 100, 10 and 1 mg/mL, resp.

Key words: ANTHRAQUINONE P, ETHOXY GROUP, METHOXY GROUP, DIHYDROXY GROUP, ANTITUMOR DRUGS, RUBIA CORDIFOLIA

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