新型苯并咪唑环蕃的合成与晶体结构研究

doi:10.6023/cjoc201209043

有机化学 ›› 2013, Vol. 33 ›› Issue (03): 643-647.DOI: 10.6023/cjoc201209043 上一篇下一篇

研究简报

新型苯并咪唑环蕃的合成与晶体结构研究

侯晓萌, 徐林飞, 唐雪松, 宋阳, 白银娟

合成与天然功能分子化学教育部重点实验室西北大学化学与材料科学学院西安 710069

收稿日期:2012-09-28 修回日期:2012-11-29 发布日期:2012-12-10
通讯作者: 白银娟 E-mail:baiyinjuan@sina.com
基金资助:
国家自然科学基金(No. 21042002)和陕西省自然科学基金(No. 2010JM2001)资助项目.

Synthesis and Crystal Structure of Novel Benzimidazole Cyclophanes

Hou Xiaomeng, Xu Linfei, Tang Xuesong, Song Yang, Bai Yinjuan

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069

Received:2012-09-28 Revised:2012-11-29 Published:2012-12-10
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21042002) and the Natural Science Foundation of Shaanxi Province (No. 2010JM2001).

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摘要/Abstract

以二溴甲基苯(o, m, p)为原料, 分别与2-巯基苯并咪唑环化合成相应的含硫苯并咪唑环蕃, 实验发现二溴甲基取代位置对反应结果有很大影响, o-位取代很易生成[1:1]型环化产物, p-位取代则主要得到链状产物, m-位取代环化产物较复杂, 但以[2:2]型环化产物为主. 产物结构通过¹H NMR, IR, HRMS进行了表征, 并得到了1-3a的X射线单晶衍射晶体结构, 对其晶体结构进行了分析.

The novel sulfur-containing benzimidazole cyclophanes were synthesized from bis(bromomethyl)benzene (o, m, p) and 2-benzimidazolinthion, respectively. The reaction showed that bromomethyl positions effected the aim compounds very much. It was easy for o-substituted to generate the [1:1] type cyclization product. p-Substituted obtained chain product, and m-substituted benzene pruduced the [2:2] type cyclization compound as main product. The lead compounds were characterized by ¹H NMR, IR, HRMS, and the structure of 1-3a was determined by X-ray diffraction method.

Key words: benzimidazole cyclophane, synthesis, characterization, crystal structure

引用此文

侯晓萌, 徐林飞, 唐雪松, 宋阳, 白银娟. 新型苯并咪唑环蕃的合成与晶体结构研究[J]. 有机化学, 2013, 33(03): 643-647.

Hou Xiaomeng, Xu Linfei, Tang Xuesong, Song Yang, Bai Yinjuan. Synthesis and Crystal Structure of Novel Benzimidazole Cyclophanes[J]. Chin. J. Org. Chem., 2013, 33(03): 643-647.

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新型苯并咪唑环蕃的合成与晶体结构研究

Synthesis and Crystal Structure of Novel Benzimidazole Cyclophanes

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