聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能

doi:10.6023/cjoc201212020

有机化学 ›› 2013, Vol. 33 ›› Issue (05): 1080-1087.DOI: 10.6023/cjoc201212020 上一篇下一篇

研究论文

聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能

马晓晔^a, 施丽君^b,c, 周涓^b, 朱君^b, 钟建^b, 魏锐利^a

a 第二军医大学附属长征医院眼科上海 200003;
b 纳米技术及应用国家工程研究中心上海 200241;
c 上海交通大学材料学院上海 200240

收稿日期:2012-12-13 修回日期:2012-12-20 发布日期:2013-01-04
通讯作者: 魏锐利,ruiliwei@gmail.com;周涓,xmcjuan@gmail.com E-mail:ruiliwei@gmail.com;xmcjuan@gmail.com
基金资助:
全军医学科技“十二五”科研(面上项目, No. CWS11J131)和上海市自然科学基金(No. 11ZR1425200)资助项目.

Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties

Ma Xiaoye^a, Shi Lijun^b,c, Zhou Juan^b, Zhu Jun^b, Zhong Jian^b, Wei Ruili^a

a Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003;
b National Engineering Research Center for Nanotechnology, Shanghai 200241;
c College of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240

Received:2012-12-13 Revised:2012-12-20 Published:2013-01-04
Supported by:
Project supported by the Army Medical Technology “12th Five-Year Plan” Scientific Research Projects of China (Surface Project, CWS11J131) and the Natural Science Foundation of Shanghai (11ZR1425200).

文章分享

摘要/Abstract

通过自由基聚合的方法合成制备了自膨胀PAAS-SF semi-IPN水凝胶(聚丙烯酸钠-丝素半互穿网络水凝胶), 并进一步探讨其作为微创治疗中组织植入物的潜能. 主要研究了SF(丝素蛋白)和AA(丙烯酸)的重量比对PAAS-SF semi-IPN水凝胶的结构、膨胀性以及力学性能的影响. 此外, 我们还研究了抗生素药物阿莫西林(AMO)在PAAS-SF semi-IPN水凝胶中的包载与释放性能. 结果表明, 随着水凝胶中SF含量的增加, 膨胀率增大, 压缩强度减小, 药物释放速率加快, 且PAAS-SF20 semi-IPN水凝胶在120 h内能释放(83.4±0.9)%的药物. 所开发的自膨胀PAAS-SF semi-IPN水凝胶具有高膨胀率和良好的药物释放能力, 将在药物输送或其它植入材料领域有良好的应用前景.

关键词: 自膨胀, 丝素蛋白, 聚丙烯酸钠, 膨胀率, 药物释放

A self-inflating hydrogel based on silk fibroin (SF) and poly(sodium acrylate) (PAAS) was synthesized by the free radical copolymerization. Furthermore, its potential as a tissue implant with minimally invasive treatment was investigated. The effects of the weight ratio of SF to AA (acrylic acid) on the structure, swelling properties and mechanical properties of the PAAS-SF semi-IPN hydrogels were investigated. In addition, the loading and release of amoxicillin of the PAAS-SF semi-IPN hydrogels were studied. With increasing SF content in the hydrogels, the swelling ratio and the rate of drug release increased, while the compressive strength decreased. It was observed that (83.4±0.9)% of the loaded drug was released within 120 h for the PAAS-SF20 semi-IPN hydrogels. The results revealed that the self-inflating PAAS-SF semi-IPN hydrogels with high swelling ratio and good drug releasing capabilities may have potential in the drug delivery or other implantable materials.

Key words: self-inflating, silk fibroin, poly(sodium acrylate), swelling ratio, drug release

引用此文

马晓晔, 施丽君, 周涓, 朱君, 钟建, 魏锐利. 聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能[J]. 有机化学, 2013, 33(05): 1080-1087.

Ma Xiaoye, Shi Lijun, Zhou Juan, Zhu Jun, Zhong Jian, Wei Ruili. Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties[J]. Chin. J. Org. Chem., 2013, 33(05): 1080-1087.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

分享此文

参考文献

[1] Kopecek, J. Biomaterials 2007, 28, 5185.
[2] Kim, J.; Peng, C.-C.; Chauhan, A. J. Controlled Release 2010, 148, 110.
[3] Sun, J.; Wang, Y.; Dou, S. Chin. Chem. Lett. 2012, 23, 97.
[4] Vashist, A.; Gupta, Y. K.; Ahmad, S. Carbohydr. Polym. 2011, 87, 1433.
[5] Schittkowski, M. P.; Guthoff, R. F. Br. J. Ophthalmol. 2006, 90, 1173.
[6] Kustner, M.; Riebeling, P.; Podmelle, F.; Kaduk, W.; Tost, F. Ophthalmologe 2009, 106, 1126.
[7] Swan, M. C.; Bucknall, D. G.; Goodacre, T. E. E.; Czernuszka, J. T. Acta Biomater. 2011, 7, 1126.
[8] Pescosolido, L.; Vermonden, T.; Malda, J.; Censi, R.; Dhert, W. J. A.; Alhaique, F.; Hennink, W. E.; Matricardi, P. Acta Biomater. 2011, 7, 1627.
[9] Wen, X.; Cao, X. L.; Yin, Z. H.; Wang, T.; Zhao, C. S. Carbohydr. Polym. 2009, 78, 193.
[10] Patel, R. B.; Solorio, L.; Wu, H.; Krupka, T.; Exner, A. A. J. Controlled Release 2010, 147, 350.
[11] Myung, D.; Koh, W.; Ko, J.; Hu, Y.; Carrasco, M.; Noolandi, J.; Ta, C. N.; Frank, C. W. Polymer 2007, 48, 5376.
[12] Yin, L.; Ding, J.; Fei, L.; He, M.; Cui, F.; Tang, C.; Yin, C. Int. J. Pharm. 2008, 350, 220.
[13] Mandal, B. B.; Kapoor, S.; Kundu, S. C. Biomaterials 2009, 30, 2826.
[14] Changez, M.; Burugapalli, K.; Koul, V.; Choudhary, V. Biomaterials 2003, 24, 527.
[15] Changez, M.; Koul, V.; Dinda, A. K. Biomaterials 2005, 26, 2095.
[16] Changez, M.; Koul, V.; Krishna, B.; Dinda, A. K.; Choudhary, V. Biomaterials 2004, 25, 139.
[17] Chang, C.; Duan, B.; Cai, J.; Zhang, L. Eur. Polym. J. 2010, 46, 92.
[18] de la Torre, P. M.; Torrado, S.; Torrado, S. Biomaterials 2003, 24, 1459.
[19] Rasool, N.; Yasin, T.; Heng, J. Y. Y.; Akhter, Z. Polymer 2010, 51, 1687.
[20] Vepari, C.; Kaplan, D. L. Prog. Polym. Sci. 2007, 32, 991.
[21] Li, C. M.; Vepari, C.; Jin, H. J.; Kim, H. J.; Kaplan, D. L. Biomaterials 2006, 27, 3115.
[22] Wenk, E.; Merkle, H. P.; Meinel, L. J. Controlled Release 2011, 150, 128.
[23] Kim, S. H.; Nam, Y. S.; Lee, T. S.; Park, W. H. Polym. J. 2003, 35, 185.
[24] Kundu, J.; Poole-Warren, L. A.; Martens, P.; Kundu, S. C. Acta Biomater. 2012, 8, 1720.
[25] Kweon, H.; Yeo, J.-H.; Lee, K.-G.; Lee, H. C.; Na, H. S.; Won, Y. H.; Cho, C. S. Biomed. Mater. 2008, 3, 034115.
[26] Hu, X.; Kaplan, D.; Cebe, P. Macromolecules 2008, 41, 3939.
[27] Teramoto, H.; Miyazawa, M. Biomacromolecules 2005, 6, 2049.
[28] Zhou, W.; Zhang, Y.; Jin, K.; Qiu, X.; Ren, X.; Hu, S.; Zhang, F. J. Appl. Polym. Sci. 2009, 114, 2828.
[29] Lu, Y.; Wang, D.; Li, T.; Zhao, X.; Cao, Y.; Yang, H.; Duan, Y. Y. Biomaterials 2009, 30, 4143.
[30] Ma, X.; Wei, R.; Cheng, J.; Cai, J.; Zhou, J. Carbohydr. Polym. 2011, 86, 313.
[31] Li, X.; Wu, W.; Wang, J.; Duan, Y. Carbohydr. Polym. 2006, 66, 473.
[32] Xu, Q.; Czernuszka, J. T. J. Controlled Release 2008, 127, 146.
[33] Torre, P. M.; Enobakhare, Y.; Torrado, G.; Torrado, S. Biomaterials 2003, 24, 1499.
[34] Lee, K. Y.; Mooney, D. J. Chem. Rev. 2001, 101, 1869.
[35] Zhou, J.; Cao, C.; Ma, X. Int. J. Biol. Macromol. 2009, 45, 504.

聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能

Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties

PDF

可视化

被引次数

摘要/Abstract

引用此文

分享此文

参考文献

相关文章 0

编辑推荐

相关统计

本文评价